Keyword search (4,028 papers available)


The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function

Author(s): Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J;...

Coronary artery disease (CAD), the leading cause of mortality worldwide, is increasingly recognized for its impact on brain health and cognition, yet the mechanisms linking CAD to vascular and meta...

Article GUID: 41452711
Basic Science and Pathogenesis

Author(s): Hervé V; KaAli OB; Benali H; Brouillette J;

Background: One of the main neuropathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid-beta oligomers (Aßo), which begins in the brain approximately 15 years prior to the onset of clinical symptoms. Aßo-induced neuronal hyper...

Article GUID: 41436083
Alzheimer s Imaging Consortium

Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; ...

Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD)....

Article GUID: 41433447
Public Health

Author(s): Gurve D; Centen AP; Slack PJ; Dang-Vu TT; Belleville S; Anderson ND; Montero-Odasso M; Nygaard HB; Chertkow H; Feldman HH; Brewster PWH; Lim...

Background: Older adults experience considerable day-to-day variability in cognitive function. We aimed to test the hypothesis that this is in part related to sleep, and determine which EEG sleep f...

Article GUID: 41434309
Basic Science and Pathogenesis

Author(s): Lamontagne-Kam D; Rahimabadi A; Bello DG; Lavallée-Beaulieu M; Fermawi AE; Bonenfant L; Nanci A; Benali H; Brouillette J;...

Background: Tau pathology is an important neuropathological marker of Alzheimer's Disease (AD) and correlates closely with neurodegeneration and cognitive decline. To date, much of the work exa...

Article GUID: 41435278
Pontine Functional Connectivity Gradients

Author(s): Rousseau PN; Bazin PL; Steele CJ;

Article GUID: 41420671
Patterns of Structural Disconnection Driving Proprioceptive Deficits in Chronic Stroke

Author(s): Kaeja M; Gajiyeva L; Iturria-Medina Y; Villringer A; Sehm B; Steele C;

Background: Stroke is a leading cause of death and disability, with proprioceptive impairments affecting up to 64% of survivors. These impairments hinder sensorimotor recovery, significantly impacting poststroke quality of life. Proprioception depends on an...

Article GUID: 41392885
Canadian Spine Society: 25th Annual Scientific Conference, February 25 to 28, 2025, Fairmont Le Manoir Richelieu, La Malbaie, Charlevoix, Que., Canada

Author(s): Chan V; Gausper A; Liu A; Andras LM; Illingworth KD; Skaggs DL; Imbeault R; Dufresne J; Parent S; Deschênes S; Roy-Beaudry M; Legler J; Benaroch L; Pirshahid AA; Serhan O; Cheng D; Bartley D; Carey...

Article GUID: 41386990
Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition

Author(s): Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ;

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a m...

Article GUID: 41353310
Title:Basic Science and Pathogenesis
Authors:Lamontagne-Kam D,  Rahimabadi A,  Bello DG,  Lavallée-Beaulieu M,  Fermawi AE,  Bonenfant L,  Nanci A,  Benali H,  Brouillette J, 
Link:https://pubmed.ncbi.nlm.nih.gov/41435278/
DOI:10.1002/alz70855_099171
Category:
PMID:41435278
Dept Affiliation: PERFORM
1 Université de Montréal, Montréal, QC, Canada.
2 Concordia University, Montreal, QC, Canada.
3 PERFORM Centre, University of Concordia, Montreal, QC, Canada.

Description:

Background: Tau pathology is an important neuropathological marker of Alzheimer's Disease (AD) and correlates closely with neurodegeneration and cognitive decline. To date, much of the work examining tau propagation has been performed using mutated tau and/or transgenic animal models. Since tau is not mutated in AD, the main objective of this study is to characterize the propagation of non-mutated tau in a mouse model.

Methods: Tau preformed fibrils (2 µg) or a vehicle solution were injected in the hippocampus of 2-month-old C57BL/6J mice. Tau propagation was evaluated at different time points following single or chronic injections (24 h after one injection, or 24 h, 1, 5, 9 or 13 weeks after 5 consecutive days of injections).

Results: Patterns of propagation and neurodegeneration were determined using a variety of fluorescent antibodies and confocal microscopy. Images of positive controls show tau hyperphosphorylation at the CA1 region of the hippocampus, as expected. Images from treatment groups will be compiled to form a 3D model of tau propagation over time.

Conclusions: Examining the propagation of non-mutated fibrils of human tau in a C57BL/6 wild-type mouse model will provide novel information regarding how tau can influence neurodegeneration and cognitive decline in the early stages of AD.