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Author(s): Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J;...
Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak...
Article GUID: 41543005
Author(s): Vaillancourt N; Montpetit C; Rosenstein B; Fortin M;
Background: Anxiety, depression, and pain-related fears are highly prevalent among individuals with chronic low back pain (CLBP). While aquatic therapy is a promising treatment modality for CLBP, its effects on psychological factors remain poorly understood...
Article GUID: 41527881
Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; ...
Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer...
Article GUID: 41512332
Author(s): Sheeran L; McIlroy S; Wong AYL; Anderson DB; Samartzis D; Bogaert L; Domokos B; Spang C; Fortin M; Hodges PW; Bizzini M; Dvorák J;
Article GUID: 41507623
Author(s): Iuliano SG; Gagnon IJ; Iverson GL; Cook NE; Zemek R; Teel EF;
This secondary analysis examined the association between preexisting mental health conditions and clinical recovery trajectories in adolescents with concussion. Adolescents (13-17; n = 1238) completed clinical assessments (Post-Concussion Symptom Inventory ...
Article GUID: 41505351
Author(s): Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J;...
Coronary artery disease (CAD), the leading cause of mortality worldwide, is increasingly recognized for its impact on brain health and cognition, yet the mechanisms linking CAD to vascular and meta...
Article GUID: 41452711
Author(s): Hervé V; KaAli OB; Benali H; Brouillette J;
Background: One of the main neuropathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid-beta oligomers (Aßo), which begins in the brain approximately 15 years prior to the onset of clinical symptoms. Aßo-induced neuronal hyper...
Article GUID: 41436083
Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; ...
Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD)....
Article GUID: 41433447
Author(s): Gurve D; Centen AP; Slack PJ; Dang-Vu TT; Belleville S; Anderson ND; Montero-Odasso M; Nygaard HB; Chertkow H; Feldman HH; Brewster PWH; Lim...
Background: Older adults experience considerable day-to-day variability in cognitive function. We aimed to test the hypothesis that this is in part related to sleep, and determine which EEG sleep f...
Article GUID: 41434309
| Title: | Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults |
| Authors: | Sanami S, Rezaei A, Tremblay SA, Potvin-Jutras Z, Sabra D, Intzandt B, Gagnon C, Mainville-Berthiaume A, Wright L, Gayda M, Iglesies-Grau J, Nigam A, Bherer L, Gauthier CJ, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/41543005/ |
| DOI: | 10.1177/0271678X251413924 |
| Category: | |
| PMID: | 41543005 |
| Dept Affiliation: | SOH
1 Department of Physics, Concordia University, Montreal, QC, Canada. 2 Centre EPIC and Research Center, Montreal Heart Institute, Montreal, QC, Canada. 3 School of Health, Concordia University, Montreal, QC, Canada. 4 Department of Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada. 5 BrainLab, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada. 6 Dr. Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada. 7 Department of Psychology, Concordia University, Montreal, QC, Canada. 8 Department of Medicine, Université de Montreal, Montreal, QC, Canada. 9 Department of Nutrition, Université de Montréal, Montreal, QC, Canada. 10 Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada. |
Description: |
Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain health, particularly higher gray matter volume and perfusion. The brain relies heavily on oxidative metabolism, yet the relationship between cardiorespiratory fitness and brain oxidative metabolism remains underexplored. This study investigated the association between VO2peak and two key cerebral metabolic parameters: the cerebral metabolic rate of oxygen consumption (CMRO2) and oxygen extraction fraction (OEF), which represents the balance between cerebral blood flow (CBF) and CMRO2. Thirty-seven healthy adults aged ?50 underwent maximal cardiopulmonary exercise testing for VO2peak assessment. Neuroimaging included dual calibrated functional MRI (dc-fMRI) and quantitative susceptibility mapping (QSM). Higher VO2peak correlated positively with higher CBF across whole-brain gray matter but showed no relationship with CMRO2. Conversely, higher VO2peak negatively correlated with lower OEF from both dc-fMRI and QSM. These findings suggest that greater cardiorespiratory fitness enhances cerebral perfusion without changing resting metabolic rate in healthy older adults, resulting in a reduced oxygen extraction. These results are consistent with exercise yielding improved vascular-metabolic coupling, which would reduce the likelihood of transient hypoxic episodes. |
