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Discovery of an adjuvant that resensitizes polymyxin B-resistant bacteria

Author(s): Mahdavi M; Findlay BL;

Infections caused by antibiotic-resistant bacteria are a major threat to health, increasing mortality rates and straining health systems worldwide. Adjuvants targeted to beta-lactamase function are able to resensitize bacteria to beta-lactam antibiotics, but there is comparatively little research into the use of adjuvants against other resistance phenotyp ...

Article GUID: 38096681


Using 13C enriched acetate in isotope labelling incubation experiments: a note of caution

Author(s): Leone F; Imfeld A; Mirzaei Y; Gélinas Y;

Vapour-phase fumigation with HCl is routinely used to remove inorganic carbon in preparation for the measurement of the concentration and d13C value of organic carbon in a sample using elemental analysis coupled to an isotope ratio mass spectrometer. Acidification of the sample to be analyzed can lead to the loss of low molecular weight conjugate bases as ...

Article GUID: 38097918


Evidence suggesting that reindeer mothers allonurse according to the direct reciprocity and generalized reciprocity decision rules

Author(s): Engelhardt SC; Weladji RB; Holand Ø; Røed KH; Nieminen M;

Allonursing is the nursing of the offspring of other mothers. Cooperation is an emergent property of evolved decision rules. Cooperation can be explained by at least three evolved decision rules: 1) direct reciprocity, i.e. help someone who previously helped you, 2) kin discrimination, i.e. preferentially direct help to kin than to non-kin, and 3) general ...

Article GUID: 38096314


A longitudinal investigation of structural empowerment profiles among healthcare employees

Author(s): Cougot B; Gillet N; Morin AJS; Gauvin J; Ollierou F; Moret L; Tripodi D;

Purpose: Research on structural empowerment has typically adopted a variable-centered perspective, which is not ideal to study the combined effects of structural empowerment components. This person-centered investigation aims to enhance our knowledge about the configurations, or profiles, of healthcare employees' perceptions of the structural empowerm ...

Article GUID: 38093467


What's control got to do with it? A systematic review of control beliefs in obsessive-compulsive disorder

Author(s): Sandstrom A; Krause S; Ouellet-Courtois C; Kelly-Turner K; Radomsky AS;

Current conceptualizations of control-related beliefs in Obsessive-Compulsive Disorder (OCD) have largely been limited to beliefs about the need to control thoughts. Although growing evidence supports the notion of considering broader control-related constructs in this disorder, there has been limited research aimed at integrating findings across studies, ...

Article GUID: 38091769


The impact of lesion side on bilateral upper limb coordination after stroke

Author(s): Shih PC; Steele CJ; Hoepfel D; Muffel T; Villringer A; Sehm B;

Background: A stroke frequently results in impaired performance of activities of daily life. Many of these are highly dependent on effective coordination between the two arms. In the context of bimanual movements, cyclic rhythmical bilateral arm coordination patterns can be classified into two fundamental modes: in-phase (bilateral homologous muscles cont ...

Article GUID: 38093308


Criminal Code reform of HIV non-disclosure is urgently needed: Social science perspectives on the harms of HIV criminalization in Canada

Author(s): Hastings C; French M; McClelland A; Mykhalovskiy E; Adam B; Bisaillon L; Bogosavljevic K; Gagnon M; Greene S; Guta A; Hindmarch S; Kaida A; Kilty J; Massaquoi N; Namaste V; O' Byrne P; Orsini M; Patterson S; Sanders C; Symington A; ...

The criminalization of HIV non-disclosure represents a significant issue of concern among people living with HIV, those working across the HIV sector, public health practitioners, and health and human rights advocates around the world. Recently, the government of Canada began a review of the crim ...

Article GUID: 38087186


Cognates are advantaged over non-cognates in early bilingual expressive vocabulary development

Author(s): Mitchell L; Tsui RK; Byers-Heinlein K;

Bilinguals need to learn two words for most concepts. These words are called translation equivalents, and those that also sound similar (e.g., banana-banane) are called cognates. Research has consistently shown that children and adults process and name cognates more easily than non-cognates. The present study explored if there is such an advantage for cog ...

Article GUID: 38087835


Children and chrono-exercise: Timing of physical activity on school and weekend days depends on sex and obesity status

Author(s): Reid RER; Henderson M; Barnett TA; Kakinami L; Tremblay A; Mathieu ME;

Recommendations for physical activity (PA) typically focus on frequency, intensity, duration, and type, but timing (chrono-exercise) is also important. The objective of this study is to describe when children are active on school and weekend days and explore PA timing across sex and body mass index (BMI) categories. 359 children (53% male), aged 9.6 (0.9) ...

Article GUID: 38083868


Single-cell imaging of protein dynamics of paralogs reveals mechanisms of gene retention

Author(s): Dandage R; Papkov M; Greco BM; Fishman D; Friesen H; Wang K; Styles E; Kraus O; Grys B; Boone C; Andrews B; Parts L; Kuzmin E;

Gene duplication is common across the tree of life, including yeast and humans, and contributes to genomic robustness. In this study, we examined changes in the subcellular localization and abundance of proteins in response to the deletion of their paralogs originating from the whole-genome dupli ...

Article GUID: 38045359


Microgeographic variation in demography and thermal regimes stabilize regional abundance of a widespread freshwater fish

Author(s): Gallagher BK; Fraser DJ;

Predicting the persistence of species under climate change is an increasingly important objective in ecological research and management. However, biotic and abiotic heterogeneity can drive asynchrony in population responses at small spatial scales, complicating species-level assessments. For widely distributed species consisting of many fragmented populat ...

Article GUID: 38071739


Condition-dependent survival and movement behavior in an endangered endemic damselfly

Author(s): Mahdjoub H; Zebsa R; Kahalerras A; Amari H; Bensouilah S; Samways MJ; Khelifa R;

Movement is essential for the maintenance of populations in their natural habitats, particularly for threatened species living in fluctuating environments. Empirical evidence suggests that the probability and distance of movement in territorial species are context-dependent, often depending on population density and sex. Here, we investigate the movement ...

Article GUID: 38071197


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