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Title		Authors	PubMed ID
1	A method of calculating initial DNA strand breakage following the decay of incorporated 125I.	Charlton DE, Humm JL	3257951 PHYSICS
2	Comments on strand breaks calculated from average doses to the DNA from incorporated isotopes.	Charlton DE	3353505 PHYSICS
3	Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.	Charlton DE, Nikjoo H, Humm JL	2569005 PHYSICS
4	Cell survival from single passages for high-LET track-segment experiments with cell monolayers.	Charlton DE, Turner MS	8248489 PHYSICS
5	Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.	Charlton DE, Allen BJ	7903342 PHYSICS
6	Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.	Charlton DE, Turner MS	8609458 PHYSICS
7	Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.	Charlton DE, Utteridge TD, Beddoe AH	8648246 PHYSICS
8	The minimum Do for cell killing for alpha-particle emitters uniformly distributed in an extended medium.	Charlton DE	9611104 PHYSICS
9	The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.	Charlton DE	10360796 PHYSICS
10	Radiation effects in spheroids of cells exposed to alpha emitters.	Charlton DE	11098858 PHYSICS

Title:	A method of calculating initial DNA strand breakage following the decay of incorporated 125I.
Authors:	Charlton DE, Humm JL
Link:	https://www.ncbi.nlm.nih.gov/pubmed/3257951?dopt=Abstract
Publication:
Keywords:
PMID:	3257951	Category:	Int J Radiat Biol Relat Stud Phys Chem Med	Date Added:	2019-06-04
Dept Affiliation:	PHYSICS

Description:

A method of calculating initial DNA strand breakage following the decay of incorporated 125I.

Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Mar;53(3):353-65

Authors: Charlton DE, Humm JL

Abstract

Two sources of individual Auger electron spectra and an electron track code were used with a simple model of the DNA to successfully simulate the single-strand DNA breakage measured by Martin and Haseltine (1981). The conditions of the calculation were then extended to examine patterns of single-strand breaks in both strands of the DNA duplex to score double-strand breaks. The occurrences of five types of break were scored. The total number of double-strand breaks (dsb) per decay at the site of the decay was 0.90 and 0.65 for the different Auger electron spectra. It was shown that for mammalian cells an additional source of double-strand breaks from low LET radiation added approximately 0.17 dsb/decay to each, giving a final total of 1.07 and 0.85 dsb/decay for mammalian cells depending on the electron spectrum. Further is is shown that the energy deposition in the DNA from the iodine decay is very complex, with a broad range of energy depositions and products. Even for a particular energy deposited in the DNA different types of strand break are produced. These are identified and their probabilities calculated.

PMID: 3257951 [PubMed - indexed for MEDLINE]

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