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PubMed Publications| Keyword search (4,163 papers available) |  |
"Morais JA" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss | Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S; | 40831565 SOH |
| 2 | Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation | Feola S; Al-Nabelsi L; Tam BT; Near J; Morais JA; Santosa S; | 39875595 HKAP |
| 3 | Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region | Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S; | 39045668 SOH |
| 4 | Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss | Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S; | 37194560 PERFORM |
| 5 | Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity | Wang C; Murphy J; Delaney KZ; Khor N; Morais JA; Tsoukas MA; Lowry DE; Mutch DM; Santosa S; | 33595419 PERFORM |
| 6 | Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity | Murphy J; Delaney KZ; Dam V; Tam BT; Khor N; Tsoukas MA; Morais JA; Santosa S; | 33179451 PERFORM |
| 7 | The Association Between Dietary Pattern Adherence, Cognitive Stimulating Lifestyle, and Cognitive Function Among Older Adults From the Quebec Longitudinal Study on Nutrition and Successful Aging | Parrott MD; Carmichael PH; Laurin D; Greenwood CE; Anderson ND; Ferland G; Gaudreau P; Belleville S; Morais JA; Kergoat MJ; Fiocco AJ; | 33063101 PERFORM |
| 8 | A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue. | Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S | 32926866 PERFORM |
| 9 | Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity. | Tam BT, Murphy J, Khor N, Morais JA, Santosa S | 32808657 PERFORM |
| 10 | Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study. | D'Amico D, Parrott MD, Greenwood CE, Ferland G, Gaudreau P, Belleville S, Laurin D, Anderson ND, Kergoat MJ, Morais JA, Presse N, Fiocco AJ, | 32563260 PERFORM |
| 11 | Obesity and ageing: Two sides of the same coin. | Tam BT, Morais JA, Santosa S | 32020741 PERFORM |
| 12 | Guidelines for Gait Assessments in the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Cullen S, Montero-Odasso M, Bherer L, Almeida Q, Fraser S, Muir-Hunter S, Li K, Liu-Ambrose T, McGibbon CA, McIlroy W, Middleton LE, Sarquis-Adamson Y, Beauchet O, McFadyen BJ, Morais JA, Camicioli R, Canadian Gait and Cognition Network | 29977431 ENCS |
| 13 | SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment. | Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini-Faria F, Shoemaker K, Speechley M, Vasudev A, Zou GY, Berryman N, Lussier M, Vanderhaeghe L, Bherer L | 29661156 PERFORM |
| 14 | Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). | Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network | 30101279 PERFORM |
| 15 | Use of routinely available clinical, nutritional, and functional criteria to classify cachexia in advanced cancer patients. | Vigano AAL, Morais JA, Ciutto L, Rosenthall L, di Tomasso J, Khan S, Olders H, Borod M, Kilgour RD | 27793524 HKAP |
| 16 | Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis. | Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S | 31131996 PERFORM |
| Title: | Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss | ||||
| Authors: | Murphy J, Tam BT, Kirkland JL, Tchkonia T, Giorgadze N, Pirtskhalava T, Tsoukas MA, Morais JA, Santosa S | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/37194560/ | ||||
| DOI: | 10.1002/oby.23745 | ||||
| Publication: | Obesity (Silver Spring, Md.) | ||||
| Keywords: | |||||
| PMID: | 37194560 | Category: | Date Added: | 2023-05-17 | |
| Dept Affiliation: |
PERFORM
1 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montréal, Québec, Canada. 2 Metabolism, Obesity, and Nutrition Laboratory, PERFORM Centre, Concordia University, Montréal, Québec, Canada. 3 Centre de recherche-Axe maladies chroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada. 4 Department of Sport, Physical Education, and Health, Faculty of Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. 5 Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. 6 Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Royal Victoria Hospital, McGill University Health Centre Glen Site, Montréal, Québec, Canada. 7 Division of Geriatric Medicine, Department of Medicine, McGill University, McGill University Health Centre-Montréal General Hospital, Montréal, Québec, Canada. |
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Description: |
Objective: The aim of this study was to determine the effect of age of obesity onset on senescence-related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before and after moderate (~10%) weight loss. Methods: AB and FEM SAT were collected from human females with childhood-onset obesity (CO) or adult-onset obesity (AO) before and after diet- and exercise-induced weight loss. Immunofluorescence analysis of ?H2AX/RAD51 (DNA damage/repair markers) and p53/p21 (senescence markers) was conducted in cultured preadipocytes, and senescence-associated ß-galactosidase (SA-ß-gal) activity was measured in SAT. Results: CO had proportionately more AB and FEM preadipocytes with DNA damage (?H2AX+ ) and senescence markers (p53+ and/or p21+ ) than AO at baseline. The proportion of ?H2AX+ FEM preadipocytes declined with weight loss in CO and was similar between groups after weight loss. The number of ?H2AX foci in ?H2AX+ preadipocytes decreased similarly between groups and regions with weight loss in parallel with an increase in RAD51. The proportion of p53+ and p21+ preadipocytes and SA-ß-gal+ cells in SAT did not change with weight loss, but the total p21 intensity in p53+ /p21+ FEM preadipocytes declined in AO. Conclusions: These results provide preliminary evidence that females with CO have an accelerated preadipocyte aging state that improves with weight loss in terms of DNA damage but not senescence. |
