Keyword search (4,163 papers available)

"Morais JA" Authored Publications:

Title Authors PubMed ID
1 The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S; 40831565
SOH
2 Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation Feola S; Al-Nabelsi L; Tam BT; Near J; Morais JA; Santosa S; 39875595
HKAP
3 Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S; 39045668
SOH
4 Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S; 37194560
PERFORM
5 Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity Wang C; Murphy J; Delaney KZ; Khor N; Morais JA; Tsoukas MA; Lowry DE; Mutch DM; Santosa S; 33595419
PERFORM
6 Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity Murphy J; Delaney KZ; Dam V; Tam BT; Khor N; Tsoukas MA; Morais JA; Santosa S; 33179451
PERFORM
7 The Association Between Dietary Pattern Adherence, Cognitive Stimulating Lifestyle, and Cognitive Function Among Older Adults From the Quebec Longitudinal Study on Nutrition and Successful Aging Parrott MD; Carmichael PH; Laurin D; Greenwood CE; Anderson ND; Ferland G; Gaudreau P; Belleville S; Morais JA; Kergoat MJ; Fiocco AJ; 33063101
PERFORM
8 A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue. Delaney KZ, Dam V, Murphy J, Morais JA, Denis R, Atlas H, Pescarus R, Garneau PY, Santosa S 32926866
PERFORM
9 Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity. Tam BT, Murphy J, Khor N, Morais JA, Santosa S 32808657
PERFORM
10 Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study. D'Amico D, Parrott MD, Greenwood CE, Ferland G, Gaudreau P, Belleville S, Laurin D, Anderson ND, Kergoat MJ, Morais JA, Presse N, Fiocco AJ, 32563260
PERFORM
11 Obesity and ageing: Two sides of the same coin. Tam BT, Morais JA, Santosa S 32020741
PERFORM
12 Guidelines for Gait Assessments in the Canadian Consortium on Neurodegeneration in Aging (CCNA). Cullen S, Montero-Odasso M, Bherer L, Almeida Q, Fraser S, Muir-Hunter S, Li K, Liu-Ambrose T, McGibbon CA, McIlroy W, Middleton LE, Sarquis-Adamson Y, Beauchet O, McFadyen BJ, Morais JA, Camicioli R, Canadian Gait and Cognition Network 29977431
ENCS
13 SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment. Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, Li K, Liu-Ambrose T, Middleton L, Muir-Hunter S, McIlroy W, Morais JA, Pieruccini-Faria F, Shoemaker K, Speechley M, Vasudev A, Zou GY, Berryman N, Lussier M, Vanderhaeghe L, Bherer L 29661156
PERFORM
14 Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA). Montero-Odasso M, Almeida QJ, Bherer L, Burhan AM, Camicioli R, Doyon J, Fraser S, Muir-Hunter S, Li KZH, Liu-Ambrose T, McIlroy W, Middleton L, Morais JA, Sakurai R, Speechley M, Vasudev A, Beauchet O, Hausdorff JM, Rosano C, Studenski S, Verghese J, Canadian Gait and Cognition Network 30101279
PERFORM
15 Use of routinely available clinical, nutritional, and functional criteria to classify cachexia in advanced cancer patients. Vigano AAL, Morais JA, Ciutto L, Rosenthall L, di Tomasso J, Khan S, Olders H, Borod M, Kilgour RD 27793524
HKAP
16 Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis. Murphy J, Bacon SL, Morais JA, Tsoukas MA, Santosa S 31131996
PERFORM

 

Title:Use of routinely available clinical, nutritional, and functional criteria to classify cachexia in advanced cancer patients.
Authors:Vigano AALMorais JACiutto LRosenthall Ldi Tomasso JKhan SOlders HBorod MKilgour RD
Link:https://www.ncbi.nlm.nih.gov/pubmed/27793524?dopt=Abstract
Publication:
Keywords:
PMID:27793524 Category:Clin Nutr Date Added:2019-05-31
Dept Affiliation: HKAP
1 McGill Nutrition and Performance Laboratory (MNUPAL), 105B, Place Vendôme, 5252 de Maisonneuve West, Montreal, Quebec, H4A 3S5, Canada; Supportive and Palliative Care, McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: antonio.vigano@mcgill.ca.
2 Geriatric Medicine, McGill University Health Centre, Royal Victoria Hospital, Room H6.61, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada. Electronic address: jose.morais@mcgill.ca.
3 McGill Nutrition and Performance Laboratory (MNUPAL), 105B, Place Vendôme, 5252 de Maisonneuve West, Montreal, Quebec, H4A 3S5, Canada; School of Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec, H9X 3V9, Canada; Centre Hospitalier Universitaire Vaudois, Service d'endocrinologie, diabétologie et métabolisme, Nutrition clinique, Bureau 08/112, Rue du Bugnon 46, 1011, Lausanne, Switzerland. Electronic address: lorella.ciutto@gmail.com.
4 Department of Radiology, McGill University Health Centre, 1650 Cedar Ave, Montreal, Quebec, H3G 1A4, Canada. Electronic address: rosenthall@bell.net.
5 McGill Nutrition and Performance Laboratory (MNUPAL), 105B, Place Vendôme, 5252 de Maisonneuve West, Montreal, Quebec, H4A 3S5, Canada; School of Dietetics and Human Nutrition, McGill University, Macdonald-Stewart Building, Macdonald Campus, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec, H9X 3V9, Canada. Electronic address: jonathan.ditomasso@mail.mcgill.ca.
6 McGill Nutrition and Performance Laboratory (MNUPAL), 105B, Place Vendôme, 5252 de Maisonneuve West, Montreal, Quebec, H4A 3S5, Canada. Electronic address: sarahkhan1655@gmail.com.
7 McGill Nutrition and Performance Laboratory (MNUPAL), 105B, Place Vendôme, 5252 de Maisonneuve West, Montreal, Quebec, H4A 3S5, Canada. Electronic address: henry.olders@mcgill.ca.
8 Supportive and Palliative Care, McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, H4A 3J1, Canada. Electronic address: mannyborod@gmail.com.
9 McGill Nutrition and Performance Laboratory (MNUPAL), 105B, Place Vendôme, 5252 de Maisonneuve West, Montreal, Quebec, H4A 3S5, Canada; Department of Exercise Science, Concordia University, The Richard J. Renaud Science Complex, Room SP-165-03, 7141 Sherbrooke Street West, Montreal, Quebec, H4B 1R6, Canada. Electronic address: kilgour.exci@gmail.com.

Description:

Use of routinely available clinical, nutritional, and functional criteria to classify cachexia in advanced cancer patients.

Clin Nutr. 2017 10;36(5):1378-1390

Authors: Vigano AAL, Morais JA, Ciutto L, Rosenthall L, di Tomasso J, Khan S, Olders H, Borod M, Kilgour RD

Abstract

BACKGROUND: Cachexia is a highly prevalent syndrome in cancer and chronic diseases. However, due to the heterogeneous features of cancer cachexia, its identification and classification challenge clinical practitioners.

OBJECTIVE: To determine the clinical relevance of a cancer cachexia classification system in advanced cancer patients.

DESIGN: Beginning with the four-stage classification system proposed for cachexia [non-cachexia (NCa), pre-cachexia (PCa), cachexia (Ca) and refractory cachexia (RCa)], we assigned patients to these cachexia stages according to five classification criteria available in clinical practice: 1) biochemistry (high C-reactive protein or leukocytes, or hypoalbuminemia, or anemia), 2) food intake (normal/decreased), weight loss: 3) moderate (=5%) or 4) significant (>5%/past six months) and 5) performance status (Eastern Cooperative Oncology Group Performance Status = 3). We then determined if symptom severity, body composition changes, functional levels, hospitalizations and survival rates varied significantly across cachexia stages.

RESULTS: Two-hundred and ninety-seven advanced cancer patients with primary gastrointestinal and lung tumors were included. Patients were classified into Ca (36%), PCa and RCa (21%, respectively) and NCa (15%). Significant (p < 0.05) differences were observed among cachexia stages for most of the outcome measures (symptoms, body composition, handgrip strength, emergency room visits and length of hospital stays) according to cachexia severity. Survival also differed between cachexia stages (except between PCa and Ca).

CONCLUSION: Five clinical criteria can be used to stage cancer cachexia patients and predict important clinical, nutritional and functional outcomes. The lack of statistical difference between PCa and Ca in almost all clinical outcomes examined suggests either that the PCa group includes patients already affected by early cachexia or that more precise criteria are needed to differentiate PCa from Ca patients. More studies are required to validate these findings.

PMID: 27793524 [PubMed - indexed for MEDLINE]





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