Keyword search (4,163 papers available)

"Phillips N" Authored Publications:

Title Authors PubMed ID
1 Biological sex and bilingualism: Its impact on risk and resilience for dementia Calvo N; Phillips N; Bialystok E; Einstein G; 41573422
PSYCHOLOGY
2 Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment Grant N; Phillips N; 40567819
PSYCHOLOGY
3 Connected speech profiles in mild cognitive impairment reflect global cognition Pellerin S; Houzé B; Bedetti C; Phillips N; Brambati SM; 40232260
PSYCHOLOGY
4 Biomarkers Grant N; Phillips N; 39785420
CONCORDIA
5 Clinical Manifestations Phillips N; Best PT; Grant N; Kabir A; 39750307
CONCORDIA
6 Clinical Manifestations Calvo N; Siddiqui R; Phillips N; Einstein G; 39750698
CONCORDIA
7 Basic Science and Pathogenesis Lima BS; Rosa-Neto P; Phillips N; Borrie M; Roncero CT; Lahiri D; Dori D; Chertkow H; 39751468
CONCORDIA
8 Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA) Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello C; Cynader M; Dang-Vu T; Das S; Dixon RA; Ducharme S; Einstein G; Evans AC; Fahnestock M; Feldman H; Ferland G; Finger E; Fisk JD; Fogarty J; Fon E; Gan-Or Z; Gauthier S; Greenwood C; Henri-Bellemare C; Herrmann N; Hogan DB; Hsiung R; Itzhak I; Jacklin K; Lanctôt K; Lim A; MacKenzie I; Masellis M; Maxwell C; McAiney C; McGilton K; McLaurin J; Mihailidis A; Mohades Z; Montero-Odasso M; Morgan D; Naglie G; Nygaard H; O' Connell M; Petersen R; Pilon R; Rajah MN; Rapoport M; Roach P; Robillard JM; Rogaeva E; Rosa-Neto P; Rylett J; Sadavoy J; St George-Hyslop P; Seitz D; Smith E; Stefanovic B; Vedel I; Walker JD; Wellington C; Whitehead V; Wittich W; 39636028
HKAP
9 Development and validation of risk of CPS decline (RCD): a new prediction tool for worsening cognitive performance among home care clients in Canada Guthrie DM; Williams N; O' Rourke HM; Orange JB; Phillips N; Pichora-Fuller MK; Savundranayagam MY; Sutradhar R; 38041046
CRDH
10 Associations Between Cardiovascular Risk Factors and Audiometric Hearing: Findings From the Canadian Longitudinal Study on Aging Mick PT; Kabir R; Pichora-Fuller MK; Jones C; Moxham L; Phillips N; Urry E; Wittich W; 37122082
PSYCHOLOGY
11 The association between information and communication technologies, loneliness and social connectedness: A scoping review Petersen B; Khalili-Mahani N; Murphy C; Sawchuk K; Phillips N; Li KZH; Hebblethwaite S; 37034933
PSYCHOLOGY
12 Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab Chertkow H; Rockwood K; Hogan DB; Phillips N; Montero-Odasso M; Amanullah S; Black S; Bocti C; Borrie M; Feldman H; Freedman M; Hsiung R; Kirk A; Masellis M; Nygaard H; Rajji T; Verret L; 34912492
PSYCHOLOGY
13 Neural correlates of resilience to the effects of hippocampal atrophy on memory. Belleville S, Mellah S, Cloutier S, Dang-Vu TT, Duchesne S, Maltezos S, Phillips N, Hudon C, CIMA-Q group 33360019
HKAP
14 CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus Montero-Odasso M; Pieruccini-Faria F; Ismail Z; Li K; Lim A; Phillips N; Kamkar N; Sarquis-Adamson Y; Speechley M; Theou O; Verghese J; Wallace L; Camicioli R; 33094146
CRDH
15 The Prevalence of Hearing, Vision, and Dual Sensory Loss in Older Canadians: An Analysis of Data from the Canadian Longitudinal Study on Aging. Mick PT, Hämäläinen A, Kolisang L, Pichora-Fuller MK, Phillips N, Guthrie D, Wittich W 32546290
PSYCHOLOGY
16 Sensory-cognitive associations are only weakly mediated or moderated by social factors in the Canadian Longitudinal Study on Aging. Hämäläinen A, Phillips N, Wittich W, Pichora-Fuller MK, Mick P 31873079
PSYCHOLOGY
17 Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment Caillaud M; Hudon C; Boller B; Brambati S; Duchesne S; Lorrain D; Gagnon JF; Maltezos S; Mellah S; Phillips N; Belleville S; 31758692
CRDH
18 Associations between sensory loss and social networks, participation, support, and loneliness: Analysis of the Canadian Longitudinal Study on Aging. Mick P, Parfyonov M, Wittich W, Phillips N, Guthrie D, Kathleen Pichora-Fuller M 29358266
PSYCHOLOGY
19 The Effects of Age and Hearing Loss on Dual-Task Balance and Listening. Bruce H, Aponte D, St-Onge N, Phillips N, Gagné JP, Li KZH 28486677
PERFORM

 

Title:Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment
Authors:Caillaud MHudon CBoller BBrambati SDuchesne SLorrain DGagnon JFMaltezos SMellah SPhillips NBelleville S
Link:https://pubmed.ncbi.nlm.nih.gov/31758692/
DOI:10.1093/geronb/gbz120
Publication:The journals of gerontology. Series B, Psychological sciences and social sciences
Keywords:Alzheimer's diseaseBiomarkersNeuroimagingNeuropsychology
PMID:31758692 Category:J Gerontol B Psychol Sci Soc Sci Date Added:2019-11-24
Dept Affiliation: CRDH
1 Research Centre, Institut universitaire de gériatrie de Montréal, Québec, Canada.
2 Department of Psychology, Université de Montréal, Québec, Canada.
3 CERVO Brain Research Centre, Institut universitaire en santé mentale de Québec, Canada.
4 Department of Psychology, Université de Laval, Québec, Canada.
5 Departement of Psychology, Université du Québec à Trois-Rivières, Québec, Canada.
6 Department of Radiology, Université de Laval, Québec, Canada.
7 Research Centre, Centre de recherche sur le vieillissement de Sherbrooke, Québec, Canada.
8 Department of Psychology, Université de Sherbrooke, Québec, Canada.
9 Department of Psychology, Université du Québec à Montréal, Québec, Canada.
10 Department of Psychology, Centre for Research in Human Development (CRDH), Concordia University, Montreal, Québec, Canada.

Description:

Objective: The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer's disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals.

Method: We included 126 participants from the Consortium for the Early Identification of Alzheimer's disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs).

Results: Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups.

Discussion: As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD's hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/prodromal phase of AD.





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