Keyword search (4,164 papers available)

"Phillips N" Authored Publications:

Title Authors PubMed ID
1 Biological sex and bilingualism: Its impact on risk and resilience for dementia Calvo N; Phillips N; Bialystok E; Einstein G; 41573422
PSYCHOLOGY
2 Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment Grant N; Phillips N; 40567819
PSYCHOLOGY
3 Connected speech profiles in mild cognitive impairment reflect global cognition Pellerin S; Houzé B; Bedetti C; Phillips N; Brambati SM; 40232260
PSYCHOLOGY
4 Biomarkers Grant N; Phillips N; 39785420
CONCORDIA
5 Clinical Manifestations Phillips N; Best PT; Grant N; Kabir A; 39750307
CONCORDIA
6 Clinical Manifestations Calvo N; Siddiqui R; Phillips N; Einstein G; 39750698
CONCORDIA
7 Basic Science and Pathogenesis Lima BS; Rosa-Neto P; Phillips N; Borrie M; Roncero CT; Lahiri D; Dori D; Chertkow H; 39751468
CONCORDIA
8 Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA) Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello C; Cynader M; Dang-Vu T; Das S; Dixon RA; Ducharme S; Einstein G; Evans AC; Fahnestock M; Feldman H; Ferland G; Finger E; Fisk JD; Fogarty J; Fon E; Gan-Or Z; Gauthier S; Greenwood C; Henri-Bellemare C; Herrmann N; Hogan DB; Hsiung R; Itzhak I; Jacklin K; Lanctôt K; Lim A; MacKenzie I; Masellis M; Maxwell C; McAiney C; McGilton K; McLaurin J; Mihailidis A; Mohades Z; Montero-Odasso M; Morgan D; Naglie G; Nygaard H; O' Connell M; Petersen R; Pilon R; Rajah MN; Rapoport M; Roach P; Robillard JM; Rogaeva E; Rosa-Neto P; Rylett J; Sadavoy J; St George-Hyslop P; Seitz D; Smith E; Stefanovic B; Vedel I; Walker JD; Wellington C; Whitehead V; Wittich W; 39636028
HKAP
9 Development and validation of risk of CPS decline (RCD): a new prediction tool for worsening cognitive performance among home care clients in Canada Guthrie DM; Williams N; O' Rourke HM; Orange JB; Phillips N; Pichora-Fuller MK; Savundranayagam MY; Sutradhar R; 38041046
CRDH
10 Associations Between Cardiovascular Risk Factors and Audiometric Hearing: Findings From the Canadian Longitudinal Study on Aging Mick PT; Kabir R; Pichora-Fuller MK; Jones C; Moxham L; Phillips N; Urry E; Wittich W; 37122082
PSYCHOLOGY
11 The association between information and communication technologies, loneliness and social connectedness: A scoping review Petersen B; Khalili-Mahani N; Murphy C; Sawchuk K; Phillips N; Li KZH; Hebblethwaite S; 37034933
PSYCHOLOGY
12 Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab Chertkow H; Rockwood K; Hogan DB; Phillips N; Montero-Odasso M; Amanullah S; Black S; Bocti C; Borrie M; Feldman H; Freedman M; Hsiung R; Kirk A; Masellis M; Nygaard H; Rajji T; Verret L; 34912492
PSYCHOLOGY
13 Neural correlates of resilience to the effects of hippocampal atrophy on memory. Belleville S, Mellah S, Cloutier S, Dang-Vu TT, Duchesne S, Maltezos S, Phillips N, Hudon C, CIMA-Q group 33360019
HKAP
14 CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus Montero-Odasso M; Pieruccini-Faria F; Ismail Z; Li K; Lim A; Phillips N; Kamkar N; Sarquis-Adamson Y; Speechley M; Theou O; Verghese J; Wallace L; Camicioli R; 33094146
CRDH
15 The Prevalence of Hearing, Vision, and Dual Sensory Loss in Older Canadians: An Analysis of Data from the Canadian Longitudinal Study on Aging. Mick PT, Hämäläinen A, Kolisang L, Pichora-Fuller MK, Phillips N, Guthrie D, Wittich W 32546290
PSYCHOLOGY
16 Sensory-cognitive associations are only weakly mediated or moderated by social factors in the Canadian Longitudinal Study on Aging. Hämäläinen A, Phillips N, Wittich W, Pichora-Fuller MK, Mick P 31873079
PSYCHOLOGY
17 Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment Caillaud M; Hudon C; Boller B; Brambati S; Duchesne S; Lorrain D; Gagnon JF; Maltezos S; Mellah S; Phillips N; Belleville S; 31758692
CRDH
18 Associations between sensory loss and social networks, participation, support, and loneliness: Analysis of the Canadian Longitudinal Study on Aging. Mick P, Parfyonov M, Wittich W, Phillips N, Guthrie D, Kathleen Pichora-Fuller M 29358266
PSYCHOLOGY
19 The Effects of Age and Hearing Loss on Dual-Task Balance and Listening. Bruce H, Aponte D, St-Onge N, Phillips N, Gagné JP, Li KZH 28486677
PERFORM

 

Title:CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus
Authors:Montero-Odasso MPieruccini-Faria FIsmail ZLi KLim APhillips NKamkar NSarquis-Adamson YSpeechley MTheou OVerghese JWallace LCamicioli R
Link:https://pubmed.ncbi.nlm.nih.gov/33094146/
DOI:10.1002/trc2.12068
Publication:Alzheimer s & dementia (New York, N. Y.)
Keywords:behaviorbiomarkercognitive impairmentdementiafrailtygaithearingolfactionparkinsonismpredictionrisksleepvision
PMID:33094146 Category:Alzheimers Dement (N Y) Date Added:2020-10-24
Dept Affiliation: CRDH
1 Gait and Brain Laboratory Parkwood Institute Lawson Health Research Institute London Ontario Canada.
2 Division of Geriatric Medicine Department of Medicine Schulich School of Medicine and Dentistry London Ontario Canada.
3 Department of Epidemiology and Biostatistics University of Western Ontario London Ontario Canada.
4 Departments of Psychiatry Clinical Neurosciences and Community Health Sciences Hotchkiss Brain Institute and O'Brien Institute for Public Health University of Calgary Calgary Alberta Canada.
5 Centre for Research in Human Development Concordia University Montreal Quebec Canada.
6 Department of Psychology Concordia University Quebec Canada.
7 Division of Neurology Department of Medicine Sunnybrook Health Sciences Centre Toronto Ontario Canada.
8 School of Physiotherapy Dalhousie University Halifax Nova Scotia Canada.
9 Department of Medicine Dalhousie University Halifax Nova Scotia Canada.
10 Department of Neurology Albert Einstein College of Medicine Bronx New York USA.
11 Division of Neurology Department of Medicine University of Alberta Edmonton Alberta Canada.

Description:

Introduction: Cognitive impairment is the hallmark of Alzheimer's disease (AD) and related dementias. However, motor decline has been recently described as a prodromal state that can help to detect at-risk individuals. Similarly, sensory changes, sleep and behavior disturbances, and frailty have been associated with higher risk of developing dementia. These clinical findings, together with the recognition that AD pathology precedes the diagnosis by many years, raises the possibility that non-cognitive changes may be early and non-invasive markers for AD or, even more provocatively, that treating non-cognitive aspects may help to prevent or treat AD and related dementias.

Methods: A subcommittee of the Canadian Consensus Conference on Diagnosis and Treatment of Dementia reviewed areas of emerging evidence for non-cognitive markers of dementia. We examined the literature for five non-cognitive domains associated with future dementia: motor, sensory (hearing, vision, olfaction), neuro-behavioral, frailty, and sleep. The Grading of Recommendations Assessment, Development, and Evaluation system was used to assign the strength of the evidence and quality of the recommendations. We provide recommendations to primary care clinics and to specialized memory clinics, answering the following main questions: (1) What are the non-cognitive and functional changes associated with risk of developing dementia? and (2) What is the evidence that sensory, motor, behavioral, sleep, and frailty markers can serve as potential predictors of dementia?

Results: Evidence supported that gait speed, dual-task gait speed, grip strength, frailty, neuropsychiatric symptoms, sleep measures, and hearing loss are predictors of dementia. There was insufficient evidence for recommending assessing olfactory and vision impairments as a predictor of dementia.

Conclusions: Non-cognitive markers can assist in identifying people at risk for cognitive decline or dementia. These non-cognitive markers may represent prodromal symptoms and several of them are potentially amenable to treatment that might delay the onset of cognitive decline.





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