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PubMed Publications| Keyword search (4,163 papers available) |  |
"de Zavalia N" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner | de Zavalia N; Schoettner K; Goldsmith JA; Solis P; Ferraro S; Parent G; Amir S; | 34702951 PSYCHOLOGY |
| 2 | In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders | Ferraro S; de Zavalia N; Belforte N; Amir S; | 34650409 CSBN |
| 3 | The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. | Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R | 31522764 CSBN |
| 4 | Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain. | Frederick A, Goldsmith J, de Zavalia N, Amir S | 28423013 BIOLOGY |
| 5 | Light-regulated translational control of circadian behavior by eIF4E phosphorylation. | Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N | 25915475 CSBN |
| 6 | Exploring the role of locomotor sensitization in the circadian food entrainment pathway. | Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S | 28301599 PSYCHOLOGY |
| 7 | mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction | Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R; | 29555746 CSBN |
| Title: | mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction | ||||
| Authors: | Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S, Sonenberg N, Cao R | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/29555746/ | ||||
| DOI: | 10.1073/pnas.1721578115 | ||||
| Publication: | Proceedings of the National Academy of Sciences of the United States of America | ||||
| Keywords: | |||||
| PMID: | 29555746 | Category: | Proc Natl Acad Sci U S A | Date Added: | 2019-05-31 |
| Dept Affiliation: |
CSBN
1 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812. 2 Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310. 3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. 4 Department of Mathematics and Statistics, Amherst College, Amherst, MA 01002. 5 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 6 Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 7 Goodman Cancer Research Center, McGill University, Montreal, QC H3A 1A3, Canada. 8 Howard Hughes Medical Institute, McGill University, Montreal, QC H3A 1A3, Canada. 9 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 10 Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455. |
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Description: |
Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the adult brain. Here we created a conditional mTOR knockout mouse model to address this question. Using the Cre-LoxP system, the mTOR gene was specifically knocked out in cells expressing Vip (vasoactive intestinal peptide), which represent a major population of interneurons widely distributed in the neocortex, suprachiasmatic nucleus (SCN), olfactory bulb (OB), and other brain regions. Using a combination of biochemical, behavioral, and imaging approaches, we found that mice lacking mTOR in VIP neurons displayed erratic circadian behavior and weakened synchronization among cells in the SCN, the master circadian pacemaker in mammals. Furthermore, we have discovered a critical role for mTOR signaling in mediating olfaction. Odor stimulated mTOR activation in the OB, anterior olfactory nucleus, as well as piriform cortex. Odor-evoked c-Fos responses along the olfactory pathway were abolished in mice lacking mTOR in VIP neurons, which is consistent with reduced olfactory sensitivity in these animals. Together, these results demonstrate that mTOR is a key regulator of SCN circadian clock synchrony and olfaction. |
