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PubMed Publications| Keyword search (4,163 papers available) |  |
"de Zavalia N" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner | de Zavalia N; Schoettner K; Goldsmith JA; Solis P; Ferraro S; Parent G; Amir S; | 34702951 PSYCHOLOGY |
| 2 | In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders | Ferraro S; de Zavalia N; Belforte N; Amir S; | 34650409 CSBN |
| 3 | The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. | Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R | 31522764 CSBN |
| 4 | Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain. | Frederick A, Goldsmith J, de Zavalia N, Amir S | 28423013 BIOLOGY |
| 5 | Light-regulated translational control of circadian behavior by eIF4E phosphorylation. | Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N | 25915475 CSBN |
| 6 | Exploring the role of locomotor sensitization in the circadian food entrainment pathway. | Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S | 28301599 PSYCHOLOGY |
| 7 | mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction | Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R; | 29555746 CSBN |
| Title: | In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders | ||||
| Authors: | Ferraro S, de Zavalia N, Belforte N, Amir S | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34650409/ | ||||
| DOI: | 10.3389/fnbeh.2021.711549 | ||||
| Publication: | Frontiers in behavioral neuroscience | ||||
| Keywords: | autism spectrum disorder; circadian rhythms; clock-gene; rhythm disturbances; rodent model; valproic acid; | ||||
| PMID: | 34650409 | Category: | Date Added: | 2021-10-15 | |
| Dept Affiliation: |
CSBN
1 Department of Psychology, Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, QC, Canada. 2 Department of Neuroscience, University of Montreal Hospital Research Center, Montreal, QC, Canada. |
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Description: |
Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterised by restrictive patterns of behaviour and alterations in social interaction and communication. Up to 80% of children with ASD exhibit sleep-wake cycle disturbances, emphasising the pressing need for novel approaches in the treatment of ASD-associated comorbidities. While sleep disturbances have been identified in ASD individuals, little has been done to assess the contribution of the circadian system to these findings. The objective of this study is to characterise circadian behaviour and clock-gene expression in a valproic acid (VPA)-induced animal model of autism to highlight perturbations potentially contributing to these disturbances. Male and female VPA-exposed offspring underwent circadian challenges, including baseline light-dark cycles, constant dark/light and light pulse protocols. Baseline analysis showed that VPA-exposed males, but not females, had a greater distribution of wheel-running behaviour across light-dark phases and a later activity offset (p < 0.0001), while controls showed greater activity confinement to the dark phase (p = 0.0256). Constant light analysis indicated an attenuated masking response and an increase in the number of days to reach arrhythmicity (p < 0.0001). A 1-h light pulse (150 lux) at CT 15 after 6 days of constant dark showed that both sexes exposed to VPA exhibited a lesser phase-shift when compared to controls (p = 0.0043). Immunohistochemical and western-blot assays reveal no alterations in retinal organisation or function. However, immunohistochemical assay of the SCN revealed altered expression of BMAL1 expression in VPA-exposed males (p = 0.0016), and in females (p = 0.0053). These findings suggest alterations within the core clockwork of the SCN and reduced photic-entrainment capacity, independent of retinal dysfunction. The results of this study shed light on the nature of circadian dysregulation in VPA-exposed animals and highlights the urgent need for novel perspectives in the treatment of ASD-associated comorbidities. |
