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PubMed Publications| Keyword search (4,163 papers available) |  |
"de Zavalia N" Authored Publications:
| Title | Authors | PubMed ID | |
|---|---|---|---|
| 1 | Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner | de Zavalia N; Schoettner K; Goldsmith JA; Solis P; Ferraro S; Parent G; Amir S; | 34702951 PSYCHOLOGY |
| 2 | In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders | Ferraro S; de Zavalia N; Belforte N; Amir S; | 34650409 CSBN |
| 3 | The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. | Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R | 31522764 CSBN |
| 4 | Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain. | Frederick A, Goldsmith J, de Zavalia N, Amir S | 28423013 BIOLOGY |
| 5 | Light-regulated translational control of circadian behavior by eIF4E phosphorylation. | Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N | 25915475 CSBN |
| 6 | Exploring the role of locomotor sensitization in the circadian food entrainment pathway. | Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S | 28301599 PSYCHOLOGY |
| 7 | mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction | Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R; | 29555746 CSBN |
| Title: | Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner | ||||
| Authors: | de Zavalia N, Schoettner K, Goldsmith JA, Solis P, Ferraro S, Parent G, Amir S | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/34702951/ | ||||
| DOI: | 10.1038/s42003-021-02715-9 | ||||
| Publication: | Communications biology | ||||
| Keywords: | |||||
| PMID: | 34702951 | Category: | Date Added: | 2021-10-27 | |
| Dept Affiliation: |
PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada. nuria.dezavalia@concordia.ca. 2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada. 3 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada. shimon.amir@concordia.ca. |
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Description: |
Alcohol consumption has been strongly associated with circadian clock gene expression in mammals. Analysis of clock genes revealed a potential role of Bmal1 in the control of alcohol drinking behavior. However, a causal role of Bmal1 and neural pathways through which it may influence alcohol intake have not yet been established. Here we show that selective ablation of Bmal1 (Cre/loxP system) from medium spiny neurons of the striatum induces sexual dimorphic alterations in alcohol consumption in mice, resulting in augmentation of voluntary alcohol intake in males and repression of intake in females. Per2mRNA expression, quantified by qPCR, decreases in the striatum after the deletion of Bmal1. To address the possibility that the effect of striatal Bmal1 deletion on alcohol intake and preference involves changes in the local expression of Per2, voluntary alcohol intake (two-bottle, free-choice paradigm) was studied in mice with a selective ablation of Per2 from medium spiny neurons of the striatum. Striatal ablation of Per2 increases voluntary alcohol intake in males but has no effect in females. Striatal Bmal1 and Per2 expression thus may contribute to the propensity to consume alcohol in a sex -specific manner in mice. |
