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PubMed Publications| Keyword search (4,163 papers available) |  |
"calcium" Keyword-tagged Publications:
| Title: | Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target | ||||
| Authors: | Li W, Shrivastava M, Lu H, Jiang Y | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/33989979/ | ||||
| DOI: | 10.1016/j.micres.2021.126786 | ||||
| Publication: | Microbiological research | ||||
| Keywords: | Antifungal targets; Calcium-calcineurin signaling pathway; Candida albicans; | ||||
| PMID: | 33989979 | Category: | Date Added: | 2021-05-19 | |
| Dept Affiliation: |
BIOLOGY
1 Department of Pharmacology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Biology, Concordia University, Montreal, QC, Canada. 3 Department of Pharmacology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: luhui2019@tongji.edu.cn. 4 Department of Pharmacology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: jiangyy@tongji.edu.cn. |
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Description: |
Increased morbidity and mortality of candidiasis are a notable threat to the immunocompromised patients. At present, the types of drugs available to treat C. albicans infection are relatively limited. Moreover, the emergence of antifungal drug resistance of C. albicans makes the treatment of C. albicans infection more difficult. The calcium-calcineurin signaling pathway plays a crucial role in the survival and pathogenicity of C. albicans and may act as a potential target against C. albicans. In this review, we summarized functions of the calcium-calcineurin signaling pathway in several biological processes, compared the differences of this signaling pathway between C. albicans and humans, and described anti-C. albicans activity of inhibitors of this signaling pathway. We believe that targeting the calcium-calcineurin signaling pathway is a promising strategy to cope with C. albicans infection. |
