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PubMed Publications| Keyword search (4,163 papers available) |  |
"calcium" Keyword-tagged Publications:
| Title: | Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection | ||||
| Authors: | Véronik Lachance | ||||
| Link: | https://pubmed.ncbi.nlm.nih.gov/36768299/ | ||||
| DOI: | 10.3390/ijms24031971 | ||||
| Publication: | International journal of molecular sciences | ||||
| Keywords: | ER stress; Sigma-1R; calcium; chaperone; endoplasmic reticulum; homeostasis; lipid; | ||||
| PMID: | 36768299 | Category: | Date Added: | 2023-02-11 | |
| Dept Affiliation: |
CSBN
1 Département des Sciences Biologiques, Université du Québec à Montréal, 141 Avenue du Président-Kennedy, Montréal, QC H2X 3X8, Canada. 2 Centre d'Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois, Pavillon des Sciences biologiques, 141 Avenue du Président-Kennedy, Montréal, QC H2X 3Y7, Canada. 3 Département de Chimie, Université du Québec à Montréal, 2101, Rue Jeanne-Mance, Montréal, QC H2X 2J6, Canada. 4 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. |
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Description: |
For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled its necessity for maintaining proper cellular homeostasis through modulation of calcium and lipid exchange between the endoplasmic reticulum (ER) and mitochondria, ER-stress response, and many other mechanisms. Most of these processes, such as ER-stress response and autophagy, have been associated with neuroprotective roles. In fact, improving these mechanisms using S1R agonists was beneficial in several... |
