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Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.

Author(s): Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Hum Brain Mapp. 2020 May 09;: Authors: Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Article GUID: 32386115
Magnetoencephalography resting state connectivity patterns as indicatives of surgical outcome in epilepsy patients.

Author(s): Aydin Ü, Pellegrino G, Bin Ka'b Ali O, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C

J Neural Eng. 2020 Mar 18;: Authors: Aydin Ü, Pellegrino G, Bin Ka'b Ali O, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 32191632
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction.

Author(s): Vorwerk J, Aydin Ü, Wolters CH, Butson CR

Front Neurosci. 2019;13:531 Authors: Vorwerk J, Aydin Ü, Wolters CH, Butson CR

Article GUID: 31231178
Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study.

Author(s): Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH

Brain Topogr. 2017 Jul;30(4):417-433 Authors: Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH

Article GUID: 28510905
Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.

Author(s): Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2018 02;39(2):880-901 Authors: Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 29164737
Title:Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction.
Authors:Vorwerk J,  Aydin Ü,  Wolters CH,  Butson CR
Link:https://www.ncbi.nlm.nih.gov/pubmed/31231178?dopt=Abstract
DOI:10.3389/fnins.2019.00531
Category:Front Neurosci
PMID:31231178
Dept Affiliation: PERFORM
1 Scientific Computing & Imaging (SCI) Institute, University of Utah, Salt Lake City, UT, United States.
2 Institute for Biomagnetism and Biosignalanalysis, University of Münster, Münster, Germany.
3 Institute of Electrical and Biomedical Engineering, UMIT - University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.
4 Multimodal Functional Imaging Lab, Department of Physics and PERFORM Centre, Concordia University, Montreal, QC, Canada.
5 Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, Germany.
6 Departments of Biomedical Engineering, Neurology, and Psychiatry, University of Utah, Salt Lake City, UT, United States.
7 Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, United States.

Description:

Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction.

Front Neurosci. 2019;13:531

Authors: Vorwerk J, Aydin Ü, Wolters CH, Butson CR

Abstract

Reliable EEG source analysis depends on sufficiently detailed and accurate head models. In this study, we investigate how uncertainties inherent to the experimentally determined conductivity values of the different conductive compartments influence the results of EEG source analysis. In a single source scenario, the superficial and focal somatosensory P20/N20 component, we analyze the influence of varying conductivities on dipole reconstructions using a generalized polynomial chaos (gPC) approach. We find that in particular the conductivity uncertainties for skin and skull have a significant influence on the EEG inverse solution, leading to variations in source localization by several centimeters. The conductivity uncertainties for gray and white matter were found to have little influence on the source localization, but a strong influence on the strength and orientation of the reconstructed source, respectively. As the CSF conductivity is most accurately determined of all conductivities in a realistic head model, CSF conductivity uncertainties had a negligible influence on the source reconstruction. This small uncertainty is a further benefit of distinguishing the CSF in realistic volume conductor models.

PMID: 31231178 [PubMed]