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Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.

Author(s): Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Hum Brain Mapp. 2020 May 09;: Authors: Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Article GUID: 32386115
Magnetoencephalography resting state connectivity patterns as indicatives of surgical outcome in epilepsy patients.

Author(s): Aydin Ü, Pellegrino G, Bin Ka'b Ali O, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C

J Neural Eng. 2020 Mar 18;: Authors: Aydin Ü, Pellegrino G, Bin Ka'b Ali O, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 32191632
Influence of Head Tissue Conductivity Uncertainties on EEG Dipole Reconstruction.

Author(s): Vorwerk J, Aydin Ü, Wolters CH, Butson CR

Front Neurosci. 2019;13:531 Authors: Vorwerk J, Aydin Ü, Wolters CH, Butson CR

Article GUID: 31231178
Zoomed MRI Guided by Combined EEG/MEG Source Analysis: A Multimodal Approach for Optimizing Presurgical Epilepsy Work-up and its Application in a Multi-focal Epilepsy Patient Case Study.

Author(s): Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH

Brain Topogr. 2017 Jul;30(4):417-433 Authors: Aydin Ü, Rampp S, Wollbrink A, Kugel H, Cho J-, Knösche TR, Grova C, Wellmer J, Wolters CH

Article GUID: 28510905
Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.

Author(s): Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2018 02;39(2):880-901 Authors: Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 29164737
Title:Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.
Authors:Chowdhury RA,  Pellegrino G,  Aydin Ü,  Lina JM,  Dubeau F,  Kobayashi E,  Grova C
Link:https://www.ncbi.nlm.nih.gov/pubmed/29164737?dopt=Abstract
DOI:10.1002/hbm.23889
Category:Hum Brain Mapp
PMID:29164737
Dept Affiliation: PERFORM
1 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montreal, Québec, Canada.
2 San Camillo Hospital IRCCS, 80 Via Alberoni, Venice, 30126, Italy.
3 Multimodal Functional Imaging Lab, Department of Physics and PERFORM Centre, Concordia University, Montreal, Québec, Canada.
4 Ecole de Technologie Supérieure, Montréal, Québec, Canada.
5 Centre de Recherches Mathématiques, Université de Montréal, Montréal, Québec, Canada.
6 Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.

Description:

Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.

Hum Brain Mapp. 2018 02;39(2):880-901

Authors: Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Abstract

Fusion of electroencephalography (EEG) and magnetoencephalography (MEG) data using maximum entropy on the mean method (MEM-fusion) takes advantage of the complementarities between EEG and MEG to improve localization accuracy. Simulation studies demonstrated MEM-fusion to be robust especially in noisy conditions such as single spike source localizations (SSSL). Our objective was to assess the reliability of SSSL using MEM-fusion on clinical data. We proposed to cluster SSSL results to find the most reliable and consistent source map from the reconstructed sources, the so-called consensus map. Thirty-four types of interictal epileptic discharges (IEDs) were analyzed from 26 patients with well-defined epileptogenic focus. SSSLs were performed on EEG, MEG, and fusion data and consensus maps were estimated using hierarchical clustering. Qualitative (spike-to-spike reproducibility rate, SSR) and quantitative (localization error and spatial dispersion) assessments were performed using the epileptogenic focus as clinical reference. Fusion SSSL provided significantly better results than EEG or MEG alone. Fusion found at least one cluster concordant with the clinical reference in all cases. This concordant cluster was always the one involving the highest number of spikes. Fusion yielded highest reproducibility (SSR EEG?=?55%, MEG?=?71%, fusion?=?90%) and lowest localization error. Also, using only few channels from either modality (21EEG + 272MEG or 54EEG + 25MEG) was sufficient to reach accurate fusion. MEM-fusion with consensus map approach provides an objective way of finding the most reliable and concordant generators of IEDs. We, therefore, suggest the pertinence of SSSL using MEM-fusion as a valuable clinical tool for presurgical evaluation of epilepsy.

PMID: 29164737 [PubMed - indexed for MEDLINE]