Keyword search (3,619 papers available)


Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease.

Author(s): Olajide OJ, Suvanto ME, Chapman CA

The entorhinal cortex (EC) is a vital component of the medial temporal lobe, and its contributions to cognitive processes and memory formation are supported through its extensive interconnections with the hippocampal formation. During the pathogenesis of Al...

Article GUID: 33495355
State-Dependent Entrainment of Prefrontal Cortex Local Field Potential Activity Following Patterned Stimulation of the Cerebellar Vermis.

Author(s): Tremblay SA, Chapman CA, Courtemanche R

Front Syst Neurosci. 2019;13:60 Authors: Tremblay SA, Chapman CA, Courtemanche R

Article GUID: 31736718
Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.

Author(s): Sparks DW, Chapman CA

J Neurophysiol. 2016 08 01;116(2):658-70 Authors: Sparks DW, Chapman CA

Article GUID: 27146979
Gap Junction Modulation of Low-Frequency Oscillations in the Cerebellar Granule Cell Layer.

Author(s): Robinson JC, Chapman CA, Courtemanche R

Cerebellum. 2017 08;16(4):802-811 Authors: Robinson JC, Chapman CA, Courtemanche R

Article GUID: 28421552
Exposure to cues associated with palatable food reward results in a dopamine D₂ receptor-dependent suppression of evoked synaptic responses in the entorhinal cortex.

Author(s): Hutter JA, Chapman CA

Behav Brain Funct. 2013 Oct 04;9:37 Authors: Hutter JA, Chapman CA

Article GUID: 24093833
Dopaminergic enhancement of excitatory synaptic transmission in layer II entorhinal neurons is dependent on D₁-like receptor-mediated signaling.

Author(s): Glovaci I, Caruana DA, Chapman CA

Neuroscience. 2014 Jan 31;258:74-83 Authors: Glovaci I, Caruana DA, Chapman CA

Article GUID: 24220689
Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.

Author(s): Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Front Syst Neurosci. 2014;8:145 Authors: Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Article GUID: 25309348
Activation of Phosphatidylinositol-Linked Dopamine Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex.

Author(s): Glovaci I, Chapman CA

PLoS One. 2015;10(7):e0131948 Authors: Glovaci I, Chapman CA

Article GUID: 26133167
Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.

Author(s): Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Cereb Cortex. 2018 Dec 01;28(12):4210-4221 Authors: Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Article GUID: 29045570
Dopamine suppresses persistent firing in layer III lateral entorhinal cortex neurons.

Author(s): Batallán-Burrowes AA, Chapman CA

Neurosci Lett. 2018 05 01;674:70-74 Authors: Batallán-Burrowes AA, Chapman CA

Article GUID: 29524644
The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Addict Biol. 2019 Jan 09;: Authors: Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Article GUID: 30623532
Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers II/III of the Parasubiculum.

Author(s): Carter F, Chapman CA

Neuroscience. 2019 May 15;406:325-332 Authors: Carter F, Chapman CA

Article GUID: 30902681
Dopamine induces release of calcium from internal stores in layer II lateral entorhinal cortex fan cells.

Author(s): Glovaci I, Chapman CA

Cell Calcium. 2019 Apr 10;80:103-111 Authors: Glovaci I, Chapman CA

Article GUID: 30999216
Title:Dopamine suppresses persistent firing in layer III lateral entorhinal cortex neurons.
Authors:Batallán-Burrowes AA,  Chapman CA
Link:https://www.ncbi.nlm.nih.gov/pubmed/29524644?dopt=Abstract
Category:Neurosci Lett
PMID:29524644
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, H4 B 1R6, Canada.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, H4 B 1R6, Canada. Electronic address: andrew.chapman@concordia.ca.

Description:

Dopamine suppresses persistent firing in layer III lateral entorhinal cortex neurons.

Neurosci Lett. 2018 05 01;674:70-74

Authors: Batallán-Burrowes AA, Chapman CA

Abstract

Persistent firing in layer III entorhinal cortex neurons that can be evoked during muscarinic receptor activation may contribute to mechanisms of working memory. The entorhinal cortex receives strong dopaminergic inputs which may modulate working memory for motivationally significant information. We used whole cell recordings in in vitro rat brain slices to assess the effects of dopamine on persistent firing in layer III neurons initiated by depolarizing current injection. Persistent firing during pharmacological block of ionotropic excitatory and inhibitory synaptic transmission, and in the presence of the cholinergic agonist carbachol (10?µM), was observed in 39% of layer III pyramidal cells. Addition of 1?µM dopamine suppressed the incidence of persistent firing and similarly reduced the mean probability of induction of persistent firing at each current step, without significantly affecting the latency, duration, plateau potential, or frequency of persistent firing that was induced. These results indicate that dopamine can result in a suppression of the induction of persistent firing in layer III entorhinal neurons, while still being permissive of persistent firing once it is initiated.

PMID: 29524644 [PubMed - indexed for MEDLINE]