Keyword search (3,448 papers available)


Cue-alcohol associative learning in female rats.

Author(s): Cofresí RU, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

The ability of environmental cues to trigger alcohol-seeking behaviors is believed to facilitate problematic alcohol use. We previously showed that the development of this cue-evoked alcohol approach reflects cue-alcohol learning and memory in the adult mal...

Article GUID: 31002878
Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Author(s): Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Nat Commun. 2020 Jul 28;11(1):3764 Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Article GUID: 32724058
Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.

Author(s): Khoo SY, Sciascia JM, Brown A, Chaudhri N

Front Behav Neurosci. 2020;14:5 Authors: Khoo SY, Sciascia JM, Brown A, Chaudhri N

Article GUID: 32116588
Context controls the timing of responses to an alcohol-predictive conditioned stimulus.

Author(s): Valyear MD, Chaudhri N

Behav Processes. 2020 Feb 01;:104061 Authors: Valyear MD, Chaudhri N

Article GUID: 32017964
Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development.

Author(s): LeCocq MR, Randall PA, Besheer J, Chaudhri N

Neurotherapeutics. 2020 Jan 02;: Authors: LeCocq MR, Randall PA, Besheer J, Chaudhri N

Article GUID: 31898285
Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula.

Author(s): Cofresí RU, Grote DJ, Le EVT, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

Alcohol. 2019 May;76:91-102 Authors: Cofresí RU, Grote DJ, Le EVT, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

Article GUID: 30612041
The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.

Author(s): Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

J Psychopharmacol. 2019 May 09;:269881119844180 Authors: Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

Article GUID: 31070082
Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats.

Author(s): Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Psychopharmacology (Berl). 2014 Feb;231(4):753-64 Authors: Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Article GUID: 24096535
The attribution of incentive salience to Pavlovian alcohol cues: a shift from goal-tracking to sign-tracking.

Author(s): Srey CS, Maddux JM, Chaudhri N

Front Behav Neurosci. 2015;9:54 Authors: Srey CS, Maddux JM, Chaudhri N

Article GUID: 25784867
Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala.

Author(s): Sciascia JM, Reese RM, Janak PH, Chaudhri N

Neuropsychopharmacology. 2015 Nov;40(12):2801-12 Authors: Sciascia JM, Reese RM, Janak PH, Chaudhri N

Article GUID: 25953360
Robust optical fiber patch-cords for in vivo optogenetic experiments in rats.

Author(s): Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

MethodsX. 2015;2:263-71 Authors: Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

Article GUID: 26150997
Varenicline Reduces Context-Induced Relapse to Alcohol-Seeking through Actions in the Nucleus Accumbens.

Author(s): Lacroix F, Pettorelli A, Maddux JN, Heidari-Jam A, Chaudhri N

Neuropsychopharmacology. 2017 Apr;42(5):1037-1048 Authors: Lacroix F, Pettorelli A, Maddux JN, Heidari-Jam A, Chaudhri N

Article GUID: 27834390
Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.

Author(s): Maddux JN, Chaudhri N

Psychopharmacology (Berl). 2017 Feb;234(4):727-738 Authors: Maddux JN, Chaudhri N

Article GUID: 28011981
Individual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue.

Author(s): Villaruel FR, Chaudhri N

Front Behav Neurosci. 2016;10:238 Authors: Villaruel FR, Chaudhri N

Article GUID: 28082877
Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats.

Author(s): Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Alcohol Clin Exp Res. 2017 03;41(3):608-617 Authors: Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Article GUID: 28169439
Alcohol-seeking and relapse: A focus on incentive salience and contextual conditioning.

Author(s): Valyear MD, Villaruel FR, Chaudhri N

Behav Processes. 2017 Aug;141(Pt 1):26-32 Authors: Valyear MD, Villaruel FR, Chaudhri N

Article GUID: 28473252
Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.

Author(s): Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Cereb Cortex. 2018 Dec 01;28(12):4210-4221 Authors: Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Article GUID: 29045570
Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats.

Author(s): Cofresí RU, Lee HJ, Monfils MH, Chaudhri N, Gonzales RA

Alcohol. 2018 Jun;69:41-49 Authors: Cofresí RU, Lee HJ, Monfils MH, Chaudhri N, Gonzales RA

Article GUID: 29635111
Modeling Relapse to Pavlovian Alcohol-Seeking in Rats Using Reinstatement and Spontaneous Recovery Paradigms.

Author(s): LeCocq MR, Lahlou S, Chahine M, Padillo LN, Chaudhri N

Alcohol Clin Exp Res. 2018 Sep;42(9):1795-1806 Authors: LeCocq MR, Lahlou S, Chahine M, Padillo LN, Chaudhri N

Article GUID: 29969151
Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding.

Author(s): Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Neuropsychopharmacology. 2019 Feb 08;: Authors: Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Article GUID: 30758331
Title:Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.
Authors:Valyear MD,  Glovaci I,  Zaari A,  Lahlou S,  Trujillo-Pisanty I,  Andrew Chapman C,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/32724058
DOI:10.1038/s41467-020-17543-4
Category:Nat Commun
PMID:32724058
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada. nadia.chaudhri@concordia.ca.

Description:

Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Nat Commun. 2020 Jul 28;11(1):3764

Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Abstract

Context can influence reactions to environmental cues and this elemental process has implications for substance use disorder. Using an animal model, we show that an alcohol-associated context elevates entry into a fluid port triggered by a conditioned stimulus (CS) that predicted alcohol (CS-triggered alcohol-seeking). This effect persists across multiple sessions and, after it diminishes in extinction, the alcohol context retains the capacity to augment reinstatement. Systemically administered eticlopride and chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons reduce CS-triggered alcohol-seeking. Chemogenetically silencing VTA dopamine terminals in the nucleus accumbens (NAc) core reduces CS-triggered alcohol-seeking, irrespective of context, whereas silencing VTA dopamine terminals in the NAc shell selectively reduces the elevation of CS-triggered alcohol-seeking in an alcohol context. This dissociation reveals new roles for divergent mesolimbic dopamine circuits in the control of responding to a discrete cue for alcohol and in the amplification of this behaviour in an alcohol context.

PMID: 32724058 [PubMed - as supplied by publisher]