Keyword search (3,448 papers available)


Cue-alcohol associative learning in female rats.

Author(s): Cofresí RU, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

The ability of environmental cues to trigger alcohol-seeking behaviors is believed to facilitate problematic alcohol use. We previously showed that the development of this cue-evoked alcohol approach reflects cue-alcohol learning and memory in the adult mal...

Article GUID: 31002878
Dissociable mesolimbic dopamine circuits control responding triggered by alcohol-predictive discrete cues and contexts.

Author(s): Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Nat Commun. 2020 Jul 28;11(1):3764 Authors: Valyear MD, Glovaci I, Zaari A, Lahlou S, Trujillo-Pisanty I, Andrew Chapman C, Chaudhri N

Article GUID: 32724058
Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.

Author(s): Khoo SY, Sciascia JM, Brown A, Chaudhri N

Front Behav Neurosci. 2020;14:5 Authors: Khoo SY, Sciascia JM, Brown A, Chaudhri N

Article GUID: 32116588
Context controls the timing of responses to an alcohol-predictive conditioned stimulus.

Author(s): Valyear MD, Chaudhri N

Behav Processes. 2020 Feb 01;:104061 Authors: Valyear MD, Chaudhri N

Article GUID: 32017964
Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development.

Author(s): LeCocq MR, Randall PA, Besheer J, Chaudhri N

Neurotherapeutics. 2020 Jan 02;: Authors: LeCocq MR, Randall PA, Besheer J, Chaudhri N

Article GUID: 31898285
Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula.

Author(s): Cofresí RU, Grote DJ, Le EVT, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

Alcohol. 2019 May;76:91-102 Authors: Cofresí RU, Grote DJ, Le EVT, Monfils MH, Chaudhri N, Gonzales RA, Lee HJ

Article GUID: 30612041
The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.

Author(s): Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

J Psychopharmacol. 2019 May 09;:269881119844180 Authors: Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N

Article GUID: 31070082
Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats.

Author(s): Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Psychopharmacology (Berl). 2014 Feb;231(4):753-64 Authors: Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Article GUID: 24096535
The attribution of incentive salience to Pavlovian alcohol cues: a shift from goal-tracking to sign-tracking.

Author(s): Srey CS, Maddux JM, Chaudhri N

Front Behav Neurosci. 2015;9:54 Authors: Srey CS, Maddux JM, Chaudhri N

Article GUID: 25784867
Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala.

Author(s): Sciascia JM, Reese RM, Janak PH, Chaudhri N

Neuropsychopharmacology. 2015 Nov;40(12):2801-12 Authors: Sciascia JM, Reese RM, Janak PH, Chaudhri N

Article GUID: 25953360
Robust optical fiber patch-cords for in vivo optogenetic experiments in rats.

Author(s): Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

MethodsX. 2015;2:263-71 Authors: Trujillo-Pisanty I, Sanio C, Chaudhri N, Shizgal P

Article GUID: 26150997
Varenicline Reduces Context-Induced Relapse to Alcohol-Seeking through Actions in the Nucleus Accumbens.

Author(s): Lacroix F, Pettorelli A, Maddux JN, Heidari-Jam A, Chaudhri N

Neuropsychopharmacology. 2017 Apr;42(5):1037-1048 Authors: Lacroix F, Pettorelli A, Maddux JN, Heidari-Jam A, Chaudhri N

Article GUID: 27834390
Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.

Author(s): Maddux JN, Chaudhri N

Psychopharmacology (Berl). 2017 Feb;234(4):727-738 Authors: Maddux JN, Chaudhri N

Article GUID: 28011981
Individual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue.

Author(s): Villaruel FR, Chaudhri N

Front Behav Neurosci. 2016;10:238 Authors: Villaruel FR, Chaudhri N

Article GUID: 28082877
Postretrieval Extinction Attenuates Alcohol Cue Reactivity in Rats.

Author(s): Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Alcohol Clin Exp Res. 2017 03;41(3):608-617 Authors: Cofresí RU, Lewis SM, Chaudhri N, Lee HJ, Monfils MH, Gonzales RA

Article GUID: 28169439
Alcohol-seeking and relapse: A focus on incentive salience and contextual conditioning.

Author(s): Valyear MD, Villaruel FR, Chaudhri N

Behav Processes. 2017 Aug;141(Pt 1):26-32 Authors: Valyear MD, Villaruel FR, Chaudhri N

Article GUID: 28473252
Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.

Author(s): Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Cereb Cortex. 2018 Dec 01;28(12):4210-4221 Authors: Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Article GUID: 29045570
Characterizing conditioned reactivity to sequential alcohol-predictive cues in well-trained rats.

Author(s): Cofresí RU, Lee HJ, Monfils MH, Chaudhri N, Gonzales RA

Alcohol. 2018 Jun;69:41-49 Authors: Cofresí RU, Lee HJ, Monfils MH, Chaudhri N, Gonzales RA

Article GUID: 29635111
Modeling Relapse to Pavlovian Alcohol-Seeking in Rats Using Reinstatement and Spontaneous Recovery Paradigms.

Author(s): LeCocq MR, Lahlou S, Chahine M, Padillo LN, Chaudhri N

Alcohol Clin Exp Res. 2018 Sep;42(9):1795-1806 Authors: LeCocq MR, Lahlou S, Chahine M, Padillo LN, Chaudhri N

Article GUID: 29969151
Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding.

Author(s): Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Neuropsychopharmacology. 2019 Feb 08;: Authors: Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Article GUID: 30758331
Title:Modeling Relapse to Pavlovian Alcohol-Seeking in Rats Using Reinstatement and Spontaneous Recovery Paradigms.
Authors:LeCocq MR,  Lahlou S,  Chahine M,  Padillo LN,  Chaudhri N
Link:https://www.ncbi.nlm.nih.gov/pubmed/29969151?dopt=Abstract
Category:Alcohol Clin Exp Res
PMID:29969151
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology/FRQS Groupe de recherche en neurobiologie comportementale, Concordia University, Montreal, Quebec, Canada.

Description:

Modeling Relapse to Pavlovian Alcohol-Seeking in Rats Using Reinstatement and Spontaneous Recovery Paradigms.

Alcohol Clin Exp Res. 2018 Sep;42(9):1795-1806

Authors: LeCocq MR, Lahlou S, Chahine M, Padillo LN, Chaudhri N

Abstract

BACKGROUND: Animal models are critical for studying causal explanations of relapse. Using a Pavlovian conditioning procedure with alcohol, we examined relapse after extinction triggered by either re-exposure to alcohol (reinstatement) or a delay between extinction and test (spontaneous recovery).

METHODS: Male, Long-Evans rats were acclimated to 15% alcohol in the home-cage using an intermittent-access 2-bottle choice procedure. Next, they received Pavlovian conditioning sessions in which an auditory-conditioned stimulus (CS; 20 second white noise; 8 trials/session; variable time 240 seconds) was paired with 15% alcohol (0.3 ml/CS; 2.4 ml/session) that was delivered into a fluid port for oral ingestion. In subsequent extinction and test sessions, CS presentations occurred as before, but without alcohol.

RESULTS: In experiment 1, exposure to either alcohol or water in the fluid port following extinction reinstated CS-elicited port entries at test 24 hours later. In a follow-up study using the same procedure (experiment 2), reinstatement was more robustly stimulated by alcohol, compared to a familiar lemon-flavored liquid. In experiment 3, systemic alcohol injections (0, 0.5, or 1.0 g/kg, intraperitoneal) administered either 24 hours or 15 minutes before test did not reinstate CS-elicited alcohol-seeking. Importantly, enzymatic assays in experiment 4 revealed detectable levels of alcohol in the blood following oral alcohol intake or intraperitoneal injection, suggesting that a pharmacological effect was likely with either route of administration. Last, in experiment 5, a 23-day delay between extinction and test resulted in a robust spontaneous recovery of CS-elicited alcohol-seeking.

CONCLUSIONS: The reinstatement and spontaneous recovery effects revealed herein provide evidence of viable new behavioral paradigms for testing interventions against relapse.

PMID: 29969151 [PubMed - in process]