Keyword search (3,168 papers available)


BOLD signal physiology: Models and applications.

Author(s): Gauthier CJ, Fan AP

Neuroimage. 2019 02 15;187:116-127 Authors: Gauthier CJ, Fan AP

Article GUID: 29544818
High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps.

Author(s): Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ

Brain Struct Funct. 2019 Jul 05;: Authors: Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ

Article GUID: 31278570
Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults.

Author(s): Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

J Cereb Blood Flow Metab. 2019 Jul 25;:271678X19862873 Authors: Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

Article GUID: 31342831
Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity.

Author(s): Tardif CL, Gauthier CJ, Steele CJ, Bazin PL, Schäfer A, Schaefer A, Turner R, Villringer A

Neuroimage. 2016 05 01;131:55-72 Authors: Tardif CL, Gauthier CJ, Steele CJ, Bazin PL, Schäfer A, Schaefer A, Turner R, Villringer A

Article GUID: 26318050
Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.

Author(s): Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

J Cereb Blood Flow Metab. 2019 Feb 07;:271678X19827944 Authors: Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

Article GUID: 30732551
Arterial stiffness and brain integrity: A review of MRI findings.

Author(s): Badji A, Sabra D, Bherer L, Cohen-Adad J, Girouard H, Gauthier CJ

Ageing Res Rev. 2019 May 04;53:100907 Authors: Badji A, Sabra D, Bherer L, Cohen-Adad J, Girouard H, Gauthier CJ

Article GUID: 31063866
Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.

Author(s): Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Front Hum Neurosci. 2015;9:66 Authors: Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Article GUID: 25741267
Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies.

Author(s): Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ

Neuroimage. 2017 04 01;149:233-243 Authors: Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ

Article GUID: 28159689
Age differences in brain signal variability are robust to multiple vascular controls.

Author(s): Garrett DD, Lindenberger U, Hoge RD, Gauthier CJ

Sci Rep. 2017 08 31;7(1):10149 Authors: Garrett DD, Lindenberger U, Hoge RD, Gauthier CJ

Article GUID: 28860455
Title:Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.
Authors:Fan AP,  Khalil AA,  Fiebach JB,  Zaharchuk G,  Villringer A,  Villringer K,  Gauthier CJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/30732551?dopt=Abstract
Category:J Cereb Blood Flow Metab
PMID:30732551
Dept Affiliation: PHYSICS
1 Department of Radiology, Stanford University, Stanford, CA, USA.
2 Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany.
3 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
4 Berlin School of Mind and Brain, Humboldt-Universitaet zu Berlin, Berlin, Germany.
5 Department of Physics, Concordia University, Montreal, Canada.
6 Montreal Heart Institute, Montreal, Canada.

Description:

Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.

J Cereb Blood Flow Metab. 2019 Feb 07;:271678X19827944

Authors: Fan AP, Khalil AA, Fiebach JB, Zaharchuk G, Villringer A, Villringer K, Gauthier CJ

Abstract

Recent clinical trials of new revascularization therapies in acute ischemic stroke have highlighted the importance of physiological imaging to identify optimal treatments for patients. Oxygen extraction fraction (OEF) is a hallmark of at-risk tissue in stroke, and can be quantified from the susceptibility effect of deoxyhemoglobin molecules in venous blood on MRI phase scans. We measured OEF within cerebral veins using advanced quantitative susceptibility mapping (QSM) MRI reconstructions in 20 acute stroke patients. Absolute OEF was elevated in the affected (29.3?±?3.4%) versus the contralateral hemisphere (25.5?±?3.1%) of patients with large diffusion-perfusion lesion mismatch ( P?=?0.032). In these patients, OEF negatively correlated with relative CBF measured by dynamic susceptibility contrast MRI ( P?=?0.004), suggesting compensation for reduced flow. Patients with perfusion-diffusion match or no hypo-perfusion showed less OEF difference between hemispheres. Nine patients received longitudinal assessment and showed OEF ratio (affected to contralateral) of 1.2?±?0.1 at baseline that normalized (decreased) to 1.0?±?0.1 at follow-up three days later ( P?=?0.03). Our feasibility study demonstrates that QSM MRI can non-invasively quantify OEF in stroke patients, relates to perfusion status, and is sensitive to OEF changes over time. Clinical trial registration: Longitudinal MRI examinations of patients with brain ischemia and blood brain barrier permeability; clinicaltrials.org : NCT02077582.

PMID: 30732551 [PubMed - as supplied by publisher]