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Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.

Author(s): DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E...

To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [11C]ABP6...

Article GUID: 33401137
Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy.

Author(s): Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Brain Topogr. 2016 Jan;29(1):162-81 Authors: Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Article GUID: 25609211
Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy.

Author(s): Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E

Hum Brain Mapp. 2016 May;37(5):1661-83 Authors: Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E

Article GUID: 26931511
Source localization of the seizure onset zone from ictal EEG/MEG data.

Author(s): Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2016 07;37(7):2528-46 Authors: Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 27059157
Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Author(s): Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Hum Brain Mapp. 2018 01;39(1):218-231 Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 29024165
Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging.

Author(s): DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E

Cereb Cortex. 2016 10 17;26(11):4170-4179 Authors: DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E

Article GUID: 27578494
Combining intraoperative ultrasound brain shift correction and augmented reality visualizations: a pilot study of eight cases.

Author(s): Gerard IJ, Kersten-Oertel M, Drouin S, Hall JA, Petrecca K, De Nigris D, Di Giovanni DA, Arbel T, Collins DL

J Med Imaging (Bellingham). 2018 Apr;5(2):021210 Authors: Gerard IJ, Kersten-Oertel M, Drouin S, Hall JA, Petrecca K, De Nigris D, Di Giovanni DA, Arbel T, Collins DL

Article GUID: 29392162
Title:Source localization of the seizure onset zone from ictal EEG/MEG data.
Authors:Pellegrino G,  Hedrich T,  Chowdhury R,  Hall JA,  Lina JM,  Dubeau F,  Kobayashi E,  Grova C
Link:https://www.ncbi.nlm.nih.gov/pubmed/27059157?dopt=Abstract
DOI:10.1002/hbm.23191
Category:Hum Brain Mapp
PMID:27059157
Dept Affiliation: PERFORM
1 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montreal, Québec, Canada.
2 Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.
3 Département de Génie Electrique, École de Technologie Supérieure, Montreal, Québec, Canada.
4 Centre De Recherches En Mathématiques, Montreal, Québec, Canada.
5 Centre D'etudes Avancées En Médecine Du Sommeil, Centre De Recherche De L'hôpital Sacré-Coeur De Montréal, Montreal, Québec, Canada.
6 Physics Department and PERFORM Centre, Concordia University, Montreal, Québec, Canada.

Description:

Source localization of the seizure onset zone from ictal EEG/MEG data.

Hum Brain Mapp. 2016 07;37(7):2528-46

Authors: Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Abstract

INTRODUCTION: Surgical treatment of drug-resistant epilepsy relies on the identification of the seizure onset zone (SOZ) and often requires intracranial EEG (iEEG). We have developed a new approach for non-invasive magnetic and electric source imaging of the SOZ (MSI-SOZ and ESI-SOZ) from ictal magnetoencephalography (MEG) and EEG recordings, using wavelet-based Maximum Entropy on the Mean (wMEM) method. We compared the performance of MSI-SOZ and ESI-SOZ with interictal spike source localization (MSI-spikes and ESI-spikes) and clinical localization of the SOZ (i.e., based on iEEG or lesion topography, denoted as clinical-SOZ).

METHODS: A total of 46 MEG or EEG seizures from 13 patients were analyzed. wMEM was applied around seizure onset, centered on the frequency band showing the strongest power change. Principal component analysis applied to spatiotemporal reconstructed wMEM sources (0.4-1 s around seizure onset) identified the main spatial pattern of ictal oscillations. Qualitative sublobar concordance and quantitative measures of distance and spatial overlaps were estimated to compare MSI/ESI-SOZ with MSI/ESI-Spikes and clinical-SOZ.

RESULTS: MSI/ESI-SOZ were concordant with clinical-SOZ in 81% of seizures (MSI 90%, ESI 64%). MSI-SOZ was more accurate and identified sources closer to the clinical-SOZ (P = 0.012) and to MSI-Spikes (P = 0.040) as compared with ESI-SOZ. MSI/ESI-SOZ and MSI/ESI-Spikes did not differ in terms of concordance and distance from the clinical-SOZ.

CONCLUSIONS: wMEM allows non-invasive localization of the SOZ from ictal MEG and EEG. MSI-SOZ performs better than ESI-SOZ. MSI/ESI-SOZ can provide important additional information to MSI/ESI-Spikes during presurgical evaluation. Hum Brain Mapp 37:2528-2546, 2016. © 2016 Wiley Periodicals, Inc.

PMID: 27059157 [PubMed - indexed for MEDLINE]