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Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.

Author(s): Hong SH, Patel T, Ip S, Garg S, Oh JK

Langmuir. 2018 03 13;34(10):3316-3325 Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK

Article GUID: 29485889
Dual disassembly and biological evaluation of enzyme/oxidation-responsive polyester-based nanoparticulates for tumor-targeting delivery.

Author(s): Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK

Colloids Surf B Biointerfaces. 2018 Dec 01;172:608-617 Authors: Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK

Article GUID: 30223243
Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment.

Author(s): Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D

ACS Nano. 2019 Jan 22;13(1):408-420 Authors: Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D

Article GUID: 30604607
Title:Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment.
Authors:Yang F,  Skripka A,  Tabatabaei MS,  Hong SH,  Ren F,  Benayas A,  Oh JK,  Martel S,  Liu X,  Vetrone F,  Ma D
Link:https://www.ncbi.nlm.nih.gov/pubmed/30604607?dopt=Abstract
Category:ACS Nano
PMID:30604607
Dept Affiliation: CHEMBIOCHEM
1 Institut National de la Recherche Scientifique, Centre Énergie, Matériaux et Télécommunications, Université du Québec , 1650 Boulevard Lionel-Boulet , Varennes , Quebec J3X 1S2 , Canada.
2 NanoRobotics Laboratory, Department of Computer and Software Engineering, Institute of Biomedical Engineering , Polytechnique Montréal , Montreal , Quebec H3T 1J4 , Canada.
3 Department of Chemistry and Biochemistry , Concordia University , Montreal , Quebec H4B 1R6 , Canada.
4 Department of Physics and CICECO-Aveiro Institute of Materials , University of Aveiro , 3810-193 , Aveiro , Portugal.
5 Department of Mechanical and Industrial Engineering , University of Toronto , 5 King's College Road , Toronto , Ontario M5S 3G8 , Canada.

Description:

Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment.

ACS Nano. 2019 Jan 22;13(1):408-420

Authors: Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D

Abstract

Developing multifunctional therapeutic and diagnostic (theranostic) nanoplatforms is critical for addressing challenging issues associated with cancers. Here, self-assembled supernanoparticles consisting of superparamagnetic Fe3O4 nanoparticles and photoluminescent PbS/CdS quantum dots whose emission lies within the second biological window (II-BW) are developed. The proposed self-assembled Fe3O4 and PbS/CdS (II-BW) supernanoparticles [SASNs (II-BW)] exhibit outstanding photoluminescence detectable through a tissue as thick as 14 mm, by overcoming severe light extinction and concomitant autofluorescence in II-BW, and significantly enhanced T2 relaxivity (282 mM-1 s-1, ca. 4 times higher than free Fe3O4 nanoparticles) due to largely enhanced magnetic field inhomogeneity. On the other hand, SASNs (II-BW) possess the dual capacity to act as both magnetothermal and photothermal agents, overcoming the main drawbacks of each type of heating separately. When SASNs (II-BW) are exposed to the dual-mode (magnetothermal and photothermal) heating, the thermal energy transfer efficiency is amplified 7-fold compared with magnetic heating alone. These results, in hand with the excellent photo- and colloidal stability, and negligible cytotoxicity, demonstrate the potential use of SASNs (II-BW) for deep-tissue bimodal (magnetic resonance and photoluminescence) in vivo imaging, while simultaneously providing the possibility of SASNs (II-BW)-mediated amplified dual-mode heating treatment for cancer therapy.

PMID: 30604607 [PubMed - in process]