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Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.

Author(s): Hong SH, Patel T, Ip S, Garg S, Oh JK

Langmuir. 2018 03 13;34(10):3316-3325 Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK

Article GUID: 29485889
Dual disassembly and biological evaluation of enzyme/oxidation-responsive polyester-based nanoparticulates for tumor-targeting delivery.

Author(s): Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK

Colloids Surf B Biointerfaces. 2018 Dec 01;172:608-617 Authors: Hong SH, Larocque K, Jaunky DB, Piekny A, Oh JK

Article GUID: 30223243
Multifunctional Self-Assembled Supernanoparticles for Deep-Tissue Bimodal Imaging and Amplified Dual-Mode Heating Treatment.

Author(s): Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D

ACS Nano. 2019 Jan 22;13(1):408-420 Authors: Yang F, Skripka A, Tabatabaei MS, Hong SH, Ren F, Benayas A, Oh JK, Martel S, Liu X, Vetrone F, Ma D

Article GUID: 30604607
Title:Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.
Authors:Hong SH,  Patel T,  Ip S,  Garg S,  Oh JK
Link:https://www.ncbi.nlm.nih.gov/pubmed/29485889?dopt=Abstract
Category:Langmuir
PMID:29485889
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry , Concordia University , Montreal , QC , Canada H4B 1R6.
2 Precision NanoSystems, Vancouver , BC , Canada V6T 1Z3.

Description:

Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.

Langmuir. 2018 03 13;34(10):3316-3325

Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK

Abstract

Controlling the size and narrow size distribution of polymer-based nanocarriers for targeted drug delivery is an important parameter that significantly influences their colloidal stability, biodistribution, and targeting ability. Herein, we report a high-throughput microfluidic process to fabricate colloidally stable aqueous nanoparticulate colloids with tunable sizes at 50-150 nm and narrow size distribution. The nanoparticulates are designed with different molecular weight polyesters having both ester bonds (responsive to esterase) and sulfide linkages (to oxidative reaction) on the backbones, thus exhibiting dual esterase/oxidation responses, causing the destabilization of the nanoparticulates to lead to the controlled release of encapsulated therapeutics. The systematic investigation on both microfluidic and formulation parameters enables to control their properties as allowing for decreasing nanoparticulate sizes as well as improving colloidal stability and cytotoxicity. Further to such control over smaller size and narrow size distribution, dual stimuli-responsive degradation and excellent cellular uptake could suggest that the microfluidic nanoparticulates stabilized with polymeric stabilizers could offer the versatility toward dual smart drug delivery exhibiting enhanced release kinetics.

PMID: 29485889 [PubMed - indexed for MEDLINE]