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Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.

Author(s): Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Les...

Nat Commun. 2019 Sep 17;10(1):4227 Authors: Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, ...

Article GUID: 31530809
Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.

Author(s): Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Front Hum Neurosci. 2015;9:66 Authors: Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Article GUID: 25741267
The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults.

Author(s): Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L

Eur J Appl Physiol. 2015 Oct;115(10):2189-97 Authors: Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L

Article GUID: 26063061
Title:The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults.
Authors:Mekari S,  Fraser S,  Bosquet L,  Bonnéry C,  Labelle V,  Pouliot P,  Lesage F,  Bherer L
Link:https://www.ncbi.nlm.nih.gov/pubmed/26063061?dopt=Abstract
DOI:10.1007/s00421-015-3199-4
Category:Eur J Appl Physiol
PMID:26063061
Dept Affiliation: PERFORM
1 Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Laboratoire LESCA, 4565, Chemin Queen-Mary, Montréal, H3W 1W5, QC, Canada. said.mekary@gmail.com.
2 Département de Kinésiologie, Université de Montréal, CP 6128, succ. Centre-ville, Montréal, H3C 3J7, QC, Canada. said.mekary@gmail.com.
3 Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, Laboratoire LESCA, 4565, Chemin Queen-Mary, Montréal, H3W 1W5, QC, Canada.
4 Département de Psychologie, Université de Québec à Montreal, C.P. 8888 succ. Centre-ville, Montréal, H3C 3P8, QC, Canada.
5 Département de Kinésiologie, Université de Montréal, CP 6128, succ. Centre-ville, Montréal, H3C 3J7, QC, Canada.
6 Faculté des Sciences du Sport, Laboratoire MOVE (EA 6314), Université de Poitiers, 8, allée Jean Monnet, 86000, Poitiers, France.
7 Département de Génie Biomédical, École Polytechnique, CP 6079, succ. Centre-ville, Montréal, H3C 3A7, QC, Canada.
8 Centre de recherche, Institut de Cardiologie de Montréal, 5000, rue Bélanger, Montréal, H1T 1C8, QC, Canada.
9 PERFORM Centre, Concordia University, 7200 Sherbrooke St. W., Montreal, QC, H4B 1R6, Canada.

Description:

The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults.

Eur J Appl Physiol. 2015 Oct;115(10):2189-97

Authors: Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L

Abstract

PURPOSE: To assess the relationship between exercise intensity, cerebral HbO2 and cognitive performance (Executive and non-Executive) in young adults.

METHODS: We measured reaction time (RT) and accuracy, during a computerized Stroop task, in 19 young adults (7 males and 12 females). Their mean ± SD age, height, body mass and body mass index (BMI) were 24 ± 4 years, 1.67 ± 0.07 m, 72 ± 14 kg and 25 ± 3 kg m(-2), respectively. Each subject performed the Stroop task at rest and during cycling at exercise of low intensity [40% of peak power output (PPO)], moderate intensity (60% of PPO) and high intensity (85% of PPO). Cerebral oxygenation was monitored during the resting and exercise conditions over the prefrontal cortex (PFC) using near-infrared spectroscopy (NIRS).

RESULTS: High-intensity exercise slowed RT in both the Naming (p = 0.04) and the Executive condition (p = 0.04). The analysis also revealed that high-intensity exercise was associated with a decreased accuracy when compared to low-intensity exercise (p = 0.021). Neuroimaging results confirm a decrease of cerebral oxygenation during high-intensity exercise in comparison to low- (p = 0.004) and moderate-intensity exercise (p = 0.003). Correlations revealed that a lower cerebral HbO2 in the prefrontal cortex was associated with slower RT in the Executive condition only (p = 0.04, g = -0.72).

CONCLUSION: Results of the present study suggest that low to moderate exercise intensity does not alter Executive functioning, but that exercise impairs cognitive functions (Executive and non-Executive) when the physical workload becomes heavy. The cerebral HbO2 correlation suggests that a lower availability of HbO2 was associated with slower RT in the Executive condition only.

PMID: 26063061 [PubMed - indexed for MEDLINE]