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Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease.

Author(s): Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Les...

Nat Commun. 2019 Sep 17;10(1):4227 Authors: Hadoux X, Hui F, Lim JKH, Masters CL, Pébay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, ...

Article GUID: 31530809
Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.

Author(s): Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Front Hum Neurosci. 2015;9:66 Authors: Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Article GUID: 25741267
The relationship between exercise intensity, cerebral oxygenation and cognitive performance in young adults.

Author(s): Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L

Eur J Appl Physiol. 2015 Oct;115(10):2189-97 Authors: Mekari S, Fraser S, Bosquet L, Bonnéry C, Labelle V, Pouliot P, Lesage F, Bherer L

Article GUID: 26063061
Title:Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.
Authors:Dupuy O,  Gauthier CJ,  Fraser SA,  Desjardins-Crèpeau L,  Desjardins M,  Mekary S,  Lesage F,  Hoge RD,  Pouliot P,  Bherer L
Link:https://www.ncbi.nlm.nih.gov/pubmed/25741267?dopt=Abstract
DOI:10.3389/fnhum.2015.00066
Category:Front Hum Neurosci
PMID:25741267
Dept Affiliation: PERFORM
1 Centre PERFORM, Université Concordia Montreal, QC, Canada ; Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Laboratoire MOVE (EA6314), Faculté des Sciences du Sport de Poitiers, Université de Poitiers Poitiers, France.
2 Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
3 Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Department of Social Work, McGill University Montreal, QC, Canada.
4 Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada.
5 Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada ; Departement de Physiologie, Université de Montréal Montreal, QC, Canada.
6 École Polytechnique de Montréal Montreal, QC, Canada.
7 Centre PERFORM, Université Concordia Montreal, QC, Canada ; Centre de Recherche de l'Institut de Gériatrie de Montréal Montreal, QC, Canada.

Description:

Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women.

Front Hum Neurosci. 2015;9:66

Authors: Dupuy O, Gauthier CJ, Fraser SA, Desjardins-Crèpeau L, Desjardins M, Mekary S, Lesage F, Hoge RD, Pouliot P, Bherer L

Abstract

AIM: Many studies have suggested that physical exercise training improves cognition and more selectively executive functions. There is a growing interest to clarify the neurophysiological mechanisms that underlie this effect. The aim of the current study was to evaluate the neurophysiological changes in cerebral oxygenation associated with physical fitness level and executive functions.

METHOD: In this study, 22 younger and 36 older women underwent a maximal graded continuous test (i.e., [Formula: see text]O2max ) in order to classify them into a fitness group (higher vs. lower fit). All participants completed neuropsychological paper and pencil testing and a computerized Stroop task (which contained executive and non-executive conditions) in which the change in prefrontal cortex oxygenation was evaluated with near infrared spectroscopy (NIRS).

RESULTS: Our findings revealed a Fitness × Condition interaction (p < 0.05) such that higher fit women scored better on measures of executive functions than lower fit women. In comparison to lower fit women, higher fit women had faster reaction times in the Executive condition of the computerized Stroop task. No significant effect was observed in the non-executive condition of the test and no interactions were found with age. In measures of cerebral oxygenation (?HbT and ?HbO2), we found a main effect of fitness on cerebral oxygenation during the Stroop task such that only high fit women demonstrated a significant increase in the right inferior frontal gyrus.

DISCUSSION/CONCLUSION: Higher fit individuals who demonstrate better cardiorespiratory functions (as measured by [Formula: see text]O2max ) show faster reaction times and greater cerebral oxygenation in the right inferior frontal gyrus than women with lower fitness levels. The lack of interaction with age, suggests that good cardiorespiratory functions can have a positive impact on cognition, regardless of age.

PMID: 25741267 [PubMed]