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Interpersonal functioning in adolescent offspring of parents with bipolar disorder.

Author(s): Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

J Affect Disord. 2009 Apr;114(1-3):122-30 Authors: Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

Article GUID: 18692905
Chronic stress and stressful life events in the offspring of parents with bipolar disorder.

Author(s): Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

J Affect Disord. 2009 Apr;114(1-3):74-84 Authors: Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

Article GUID: 18814916
High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.

Author(s): Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Bipolar Disord. 2010 Feb;12(1):77-86 Authors: Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Article GUID: 20148869
Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?

Author(s): Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

J Affect Disord. 2011 Jul;132(1-2):265-9 Authors: Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

Article GUID: 21329985
Acute intranasal oxytocin improves positive self-perceptions of personality.

Author(s): Cardoso C, Ellenbogen MA, Linnen AM

Psychopharmacology (Berl). 2012 Apr;220(4):741-9 Authors: Cardoso C, Ellenbogen MA, Linnen AM

Article GUID: 22012170
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students.

Author(s): Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Stress. 2012 Jul;15(4):393-402 Authors: Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Article GUID: 22044077
The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces.

Author(s): Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Psychophysiology. 2012 Jan;49(1):128-37 Authors: Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Article GUID: 22092248
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychoneuroendocrinology. 2013 Mar;38(3):387-98 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 22902063
Salivary cortisol and interpersonal functioning: an event-contingent recording study in the offspring of parents with bipolar disorder.

Author(s): Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN

Psychoneuroendocrinology. 2013 Jul;38(7):997-1006 Authors: Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN

Article GUID: 23131593
Stress-induced negative mood moderates the relation between oxytocin administration and trust: evidence for the tend-and-befriend response to stress?

Author(s): Cardoso C, Ellenbogen MA, Serravalle L, Linnen AM

Psychoneuroendocrinology. 2013 Nov;38(11):2800-4 Authors: Cardoso C, Ellenbogen MA, Serravalle L, Linnen AM

Article GUID: 23768973
Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychophysiology. 2014 Nov;51(11):1169-77 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 25082371
Title:Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?
Authors:Ellenbogen MA,  Hodgins S,  Linnen AM,  Ostiguy CS
Link:https://www.ncbi.nlm.nih.gov/pubmed/21329985?dopt=Abstract
Category:J Affect Disord
PMID:21329985
Dept Affiliation: CRDH
1 Centre for Research in Human Development, Concordia University, Montréal (Québec), Canada. mark.ellenbogen@concordia.ca

Description:

Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?

J Affect Disord. 2011 Jul;132(1-2):265-9

Authors: Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

Abstract

BACKGROUND: Several studies have reported that the offspring of parents with affective disorders secrete high levels of daytime cortisol. A few studies have shown that high cortisol levels preceded the onset of affective symptoms. Only one study to date has found that an elevation in cortisol preceded the onset of an affective disorder, but this was observed only in those youth carrying the short allele of the serotonin transporter gene promoter polymorphism (Goodyer et al., 2009).

METHODS: We followed 28 offspring of parents with bipolar disorder and 31 offspring of parents with no affective disorder from an average age of 17.5years to an average age of 20.0years to determine if cortisol levels at baseline predicted the subsequent development of an affective disorder. At baseline and at follow-up participants completed a diagnostic assessment, and at baseline they provided saliva samples. Daytime cortisol levels were computed as the mean of eight to 24 samples measured across two to six days.

RESULTS: Among the 59 participants, cortisol levels at the mean age of 17.5years predicted the development of an affective disorder during the subsequent 2.5year (odds ratio: 2.1, 95% confidence interval=1.0-4.1, p<0.05) after controlling for offspring mental disorders at the first assessment and having a parent with bipolar disorder.

LIMITATIONS: The findings should be interpreted with caution, as the sample size was small.

CONCLUSION: Elevated daytime cortisol levels in late adolescence may be a biomarker of vulnerability for affective disorders.

PMID: 21329985 [PubMed - indexed for MEDLINE]