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Interpersonal functioning in adolescent offspring of parents with bipolar disorder.

Author(s): Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

J Affect Disord. 2009 Apr;114(1-3):122-30 Authors: Linnen AM, aan het Rot M, Ellenbogen MA, Young SN

Article GUID: 18692905
Chronic stress and stressful life events in the offspring of parents with bipolar disorder.

Author(s): Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

J Affect Disord. 2009 Apr;114(1-3):74-84 Authors: Ostiguy CS, Ellenbogen MA, Linnen AM, Walker EF, Hammen C, Hodgins S

Article GUID: 18814916
High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.

Author(s): Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Bipolar Disord. 2010 Feb;12(1):77-86 Authors: Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Article GUID: 20148869
Elevated daytime cortisol levels: a biomarker of subsequent major affective disorder?

Author(s): Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

J Affect Disord. 2011 Jul;132(1-2):265-9 Authors: Ellenbogen MA, Hodgins S, Linnen AM, Ostiguy CS

Article GUID: 21329985
Acute intranasal oxytocin improves positive self-perceptions of personality.

Author(s): Cardoso C, Ellenbogen MA, Linnen AM

Psychopharmacology (Berl). 2012 Apr;220(4):741-9 Authors: Cardoso C, Ellenbogen MA, Linnen AM

Article GUID: 22012170
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students.

Author(s): Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Stress. 2012 Jul;15(4):393-402 Authors: Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Article GUID: 22044077
The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces.

Author(s): Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Psychophysiology. 2012 Jan;49(1):128-37 Authors: Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Article GUID: 22092248
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychoneuroendocrinology. 2013 Mar;38(3):387-98 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 22902063
Salivary cortisol and interpersonal functioning: an event-contingent recording study in the offspring of parents with bipolar disorder.

Author(s): Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN

Psychoneuroendocrinology. 2013 Jul;38(7):997-1006 Authors: Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN

Article GUID: 23131593
Stress-induced negative mood moderates the relation between oxytocin administration and trust: evidence for the tend-and-befriend response to stress?

Author(s): Cardoso C, Ellenbogen MA, Serravalle L, Linnen AM

Psychoneuroendocrinology. 2013 Nov;38(11):2800-4 Authors: Cardoso C, Ellenbogen MA, Serravalle L, Linnen AM

Article GUID: 23768973
Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychophysiology. 2014 Nov;51(11):1169-77 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 25082371
Title:High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.
Authors:Ellenbogen MA,  Santo JB,  Linnen AM,  Walker CD,  Hodgins S
Link:https://www.ncbi.nlm.nih.gov/pubmed/20148869?dopt=Abstract
Category:Bipolar Disord
PMID:20148869
Dept Affiliation: CRDH
1 Centre for Research in Human Development, Concordia University, Montréal, Quebec, Canada. mark.ellenbogen@concordia.ca

Description:

High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling.

Bipolar Disord. 2010 Feb;12(1):77-86

Authors: Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S

Abstract

OBJECTIVES: The hypothalamic-pituitary-adrenal (HPA) axis is compromised in major depression, bipolar disorder (BD), and in the offspring of parents with major depression. Less is known about the offspring of parents with BD (FH+). The present project provides follow-up to a previous study showing that the adolescent (mean age 16.7 years) FH+ offspring had higher salivary cortisol levels than the offspring of parents with no mental disorder (FH-) throughout the day in their natural environment, and that girls had higher cortisol levels than boys (Ellenbogen MA, Hodgins S, Walker C-D, Adam S, Couture S. Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder. Psychoneuroendocrinology 2006; 31: 1164-1180). The goal of the present study was to determine whether FH+ offspring, approximately two years later, continued to exhibit elevated cortisol levels relative to FH- offspring during two weeks of daily sampling.

METHODS: The present study examined salivary cortisol levels in 24 (18.3 +/- 2.6 years) FH+ and 22 (18.0 +/- 2.3 years) FH- offspring who are part of the same longitudinal cohort as the previous study. Saliva was collected at 1300 h and 1500 h in the natural environment of the offspring during 14 consecutive days.

RESULTS: Multilevel modelling analyses indicated that FH+ offspring had higher afternoon levels of cortisol in their natural environment than FH- offspring, but group differences in slope and gender differences were not found.

CONCLUSIONS: The FH+ offspring exhibited increased daytime secretion of cortisol that, at the level of the group, persisted into late adolescence and young adulthood. Perhaps this change in HPA functioning is associated with an increased vulnerability for the development of an affective disorder.

PMID: 20148869 [PubMed - indexed for MEDLINE]