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A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES: We investigated the...

Article GUID: 31811350
Effects of contingent and noncontingent nicotine on lever pressing for liquids and consumption in water-deprived rats.

Author(s): Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Eur J Pharmacol. 2017 Jan 05;794:224-233 Authors: Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Article GUID: 27889434
A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats.

Author(s): Sedki F, Eigenmann K, Gelinas J, Schouela N, Courchesne S, Shalev U

Addict Biol. 2015 May;20(3):423-32 Authors: Sedki F, Eigenmann K, Gelinas J, Schouela N, Courchesne S, Shalev U

Article GUID: 24725195
Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.

Author(s): Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Psychopharmacology (Berl). 2015 Oct;232(20):3773-82 Authors: Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Article GUID: 26246318
Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core.

Author(s): D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Neuropsychopharmacology. 2017 Apr;42(5):1136-1145 Authors: D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Article GUID: 27824052
Exploring the role of locomotor sensitization in the circadian food entrainment pathway.

Author(s): Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

PLoS One. 2017;12(3):e0174113 Authors: Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

Article GUID: 28301599
Effects of chronic prenatal MK-801 treatment on object recognition, cognitive flexibility, and drug-induced locomotor activity in juvenile and adult rat offspring.

Author(s): Gallant S, Welch L, Martone P, Shalev U

Behav Brain Res. 2017 06 15;328:62-69 Authors: Gallant S, Welch L, Martone P, Shalev U

Article GUID: 28390877
The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Addict Biol. 2019 Jan 09;: Authors: Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Article GUID: 30623532
Title:A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.
Authors:D'Cunha TM,  Chisholm A,  Hryhorczuk C,  Fulton S,  Shalev U
Link:https://www.ncbi.nlm.nih.gov/pubmed/31811350
DOI:10.1007/s00213-019-05415-9
Category:Psychopharmacology (Berl)
PMID:31811350
Dept Affiliation: PSYCHOLOGY
1 Department of Psychology, Concordia University, Montreal, Quebec, Canada.
2 Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada.
3 Centre de Recherche du CHUM, Montreal Diabetes Research Centre, Université de Montréal, Quebec, Canada.
4 Department of Psychology, Concordia University, Montreal, Quebec, Canada. uri.shalev@concordia.ca.
5 Center for Studies in Behavioral Neurobiology (CSBN), Montreal, Canada. uri.shalev@concordia.ca.

Description:

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors.

OBJECTIVES: We investigated the role of leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

METHODS: Rats self-administered heroin (0.1 mg/kg/infusion) for 10 days followed by 14 days of drug withdrawal. During withdrawal, rats were food restricted to 90% of their original body weight or were given free access to food. In experiment 1, we measured the plasma concentrations of leptin and ghrelin following heroin self-administration and withdrawal. In experiment 2, leptin was administered centrally (2.0 or 4.0 µg; i.c.v.) prior to a heroin-seeking test under extinction conditions. High density of both leptin and ghrelin receptors was previously identified in the ventral tegmental area (VTA), suggesting a direct effect on reward and motivation. Hence, we administered leptin (experiment 3; 0.125 or 0.250 µg/side), or ghrelin receptor antagonist JMV 2959 (experiment 4; 2.0 or 10.0 µg/side) directly into the VTA prior to the heroin-seeking test.

RESULTS: Chronic food restriction significantly decreased plasma levels of leptin and elevated plasma levels of ghrelin. Central administration of leptin had no statistically significant effect on heroin seeking. Intra-VTA administration of either leptin or JMV 2959 dose-dependently and selectively decreased heroin seeking in the food-restricted rats.

CONCLUSIONS: Leptin and ghrelin transmission in the VTA can modulate the augmentation of heroin seeking induced by chronic food restriction.

PMID: 31811350 [PubMed - indexed for MEDLINE]