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A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES: We investigated the...

Article GUID: 31811350
Effects of contingent and noncontingent nicotine on lever pressing for liquids and consumption in water-deprived rats.

Author(s): Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Eur J Pharmacol. 2017 Jan 05;794:224-233 Authors: Frenk H, Martin J, Vitouchanskaia C, Dar R, Shalev U

Article GUID: 27889434
A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats.

Author(s): Sedki F, Eigenmann K, Gelinas J, Schouela N, Courchesne S, Shalev U

Addict Biol. 2015 May;20(3):423-32 Authors: Sedki F, Eigenmann K, Gelinas J, Schouela N, Courchesne S, Shalev U

Article GUID: 24725195
Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.

Author(s): Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Psychopharmacology (Berl). 2015 Oct;232(20):3773-82 Authors: Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Article GUID: 26246318
Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core.

Author(s): D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Neuropsychopharmacology. 2017 Apr;42(5):1136-1145 Authors: D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Article GUID: 27824052
Exploring the role of locomotor sensitization in the circadian food entrainment pathway.

Author(s): Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

PLoS One. 2017;12(3):e0174113 Authors: Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

Article GUID: 28301599
Effects of chronic prenatal MK-801 treatment on object recognition, cognitive flexibility, and drug-induced locomotor activity in juvenile and adult rat offspring.

Author(s): Gallant S, Welch L, Martone P, Shalev U

Behav Brain Res. 2017 06 15;328:62-69 Authors: Gallant S, Welch L, Martone P, Shalev U

Article GUID: 28390877
The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Addict Biol. 2019 Jan 09;: Authors: Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Article GUID: 30623532
Title:The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.
Authors:Chisholm A,  Iannuzzi J,  Rizzo D,  Gonzalez N,  Fortin É,  Bumbu A,  Batallán Burrowes AA,  Chapman CA,  Shalev U
Link:https://www.ncbi.nlm.nih.gov/pubmed/30623532?dopt=Abstract
Category:Addict Biol
PMID:30623532
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Canada.

Description:

The role of the paraventricular nucleus of the thalamus in the augmentation of heroin seeking induced by chronic food restriction.

Addict Biol. 2019 Jan 09;:

Authors: Chisholm A, Iannuzzi J, Rizzo D, Gonzalez N, Fortin É, Bumbu A, Batallán Burrowes AA, Chapman CA, Shalev U

Abstract

Drug addiction is a chronic disorder that is characterized by compulsive drug seeking and involves cycling between periods of compulsive drug use, abstinence, and relapse. In both human addicts and animal models of addiction, chronic food restriction has been shown to increase rates of relapse. Previously, our laboratory has demonstrated a robust increase in drug seeking following a period of withdrawal in chronically food-restricted rats compared with sated rats. To date, the neural mechanisms that mediate the effect of chronic food restriction on drug seeking have not been elucidated. However, the paraventricular nucleus of the thalamus (PVT) appears to be a promising target to investigate. The objective of the current study was to examine the role of the PVT in the augmentation of heroin seeking induced by chronic food restriction. Male Long-Evans rats were trained to self-administer heroin for 10 days. Rats were then removed from the training chambers and experienced a 14-day withdrawal period with either unrestricted (sated) or mildly restricted (FDR) access to food. On day 14, rats underwent a 1-hour heroin-seeking test under extinction conditions, during which neural activity in the PVT was either inhibited or increased using pharmacological or chemogenetic approaches. Unexpectedly, inhibition of the PVT did not alter heroin seeking in food-restricted or sated rats, while enhancing neural activity in the PVT-attenuated heroin seeking in food-restricted rats. These results indicate that PVT activity can modulate heroin seeking induced by chronic food restriction.

PMID: 30623532 [PubMed - as supplied by publisher]