Keyword search (3,619 papers available)


Improving Safety of MRI in Patients with Deep Brain Stimulation Devices.

Author(s): Boutet A, Chow CT, Narang K, Elias GJB, Neudorfer C, Germann J, Ranjan M, Loh A, Martin AJ, Kucharczyk W, Steele CJ, Hancu I, Rezai AR, Lozano AM

Radiology. 2020 Jun 23;:192291 Authors: Boutet A, Chow CT, Narang K, Elias GJB, Neudorfer C, Germann J, Ranjan M, Loh A, Martin AJ, Kucharczyk W, Steele CJ, Hancu I, Rezai AR, Lozano AM

Article GUID: 32573388
Investigating microstructural variation in the human hippocampus using non-negative matrix factorization.

Author(s): Patel R, Steele CJ, Chen A, Patel S, Devenyi GA, Germann J, Tardif CL, Chakravarty MM

Neuroimage. 2019 Nov 09;:116348 Authors: Patel R, Steele CJ, Chen A, Patel S, Devenyi GA, Germann J, Tardif CL, Chakravarty MM

Article GUID: 31715254
High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps.

Author(s): Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ

Brain Struct Funct. 2019 Jul 05;: Authors: Huck J, Wanner Y, Fan AP, Jäger AT, Grahl S, Schneider U, Villringer A, Steele CJ, Tardif CL, Bazin PL, Gauthier CJ

Article GUID: 31278570
Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults.

Author(s): Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

J Cereb Blood Flow Metab. 2019 Jul 25;:271678X19862873 Authors: Intzandt B, Sabra D, Foster C, Desjardins-Crépeau L, Hoge RD, Steele CJ, Bherer L, Gauthier CJ

Article GUID: 31342831
Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity.

Author(s): Tardif CL, Gauthier CJ, Steele CJ, Bazin PL, Schäfer A, Schaefer A, Turner R, Villringer A

Neuroimage. 2016 05 01;131:55-72 Authors: Tardif CL, Gauthier CJ, Steele CJ, Bazin PL, Schäfer A, Schaefer A, Turner R, Villringer A

Article GUID: 26318050
Practice makes plasticity.

Author(s): Steele CJ, Zatorre RJ

Nat Neurosci. 2018 12;21(12):1645-1646 Authors: Steele CJ, Zatorre RJ

Article GUID: 30482944
Kinematic profiles suggest differential control processes involved in bilateral in-phase and anti-phase movements.

Author(s): Shih PC, Steele CJ, Nikulin V, Villringer A, Sehm B

Sci Rep. 2019 Mar 01;9(1):3273 Authors: Shih PC, Steele CJ, Nikulin V, Villringer A, Sehm B

Article GUID: 30824858
Neuroimaging Technological Advancements for Targeting in Functional Neurosurgery.

Author(s): Boutet A, Gramer R, Steele CJ, Elias GJB, Germann J, Maciel R, Kucharczyk W, Zrinzo L, Lozano AM, Fasano A

Curr Neurol Neurosci Rep. 2019 May 30;19(7):42 Authors: Boutet A, Gramer R, Steele CJ, Elias GJB, Germann J, Maciel R, Kucharczyk W, Zrinzo L, Lozano AM, Fasano A

Article GUID: 31144155
Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies.

Author(s): Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ

Neuroimage. 2017 04 01;149:233-243 Authors: Tardif CL, Steele CJ, Lampe L, Bazin PL, Ragert P, Villringer A, Gauthier CJ

Article GUID: 28159689
Title:Investigating microstructural variation in the human hippocampus using non-negative matrix factorization.
Authors:Patel R,  Steele CJ,  Chen A,  Patel S,  Devenyi GA,  Germann J,  Tardif CL,  Chakravarty MM
Link:https://www.ncbi.nlm.nih.gov/pubmed/31715254?dopt=Abstract
DOI:10.1016/j.neuroimage.2019.116348
Category:Neuroimage
PMID:31715254
Dept Affiliation: PSYCHOLOGY
1 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, Canada. Electronic address: mohammed.patel@mail.mcgill.ca.
2 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada; Department of Psychology, Concordia University, Montreal, Quebec, H4B 1R6, Canada; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
3 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada; School of Computer Science, McGill University, Montreal, Canada.
4 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada.
5 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada; Department of Psychiatry, McGill University, Montreal, Canada.
6 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada; University Health Network, Toronto, Canada.
7 Department of Biological and Biomedical Engineering, McGill University, Montreal, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
8 Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, Canada; Department of Psychiatry, McGill University, Montreal, Canada. Electronic address: mallar@cobralab.ca.

Description:

Investigating microstructural variation in the human hippocampus using non-negative matrix factorization.

Neuroimage. 2019 Nov 09;:116348

Authors: Patel R, Steele CJ, Chen A, Patel S, Devenyi GA, Germann J, Tardif CL, Chakravarty MM

Abstract

In this work we use non-negative matrix factorization to identify patterns of microstructural variance in the human hippocampus. We utilize high-resolution structural and diffusion magnetic resonance imaging data from the Human Connectome Project to query hippocampus microstructure on a multivariate, voxelwise basis. Application of non-negative matrix factorization identifies spatial components (clusters of voxels sharing similar covariance patterns), as well as subject weightings (individual variance across hippocampus microstructure). By assessing the stability of spatial components as well as the accuracy of factorization, we identified 4 distinct microstructural components. Furthermore, we quantified the benefit of using multiple microstructural metrics by demonstrating that using three microstructural metrics (T1-weighted/T2-weighted signal, mean diffusivity and fractional anisotropy) produced more stable spatial components than when assessing metrics individually. Finally, we related individual subject weightings to demographic and behavioural measures using a partial least squares analysis. Through this approach we identified interpretable relationships between hippocampus microstructure and demographic and behavioural measures. Taken together, our work suggests non-negative matrix factorization as a spatially specific analytical approach for neuroimaging studies and advocates for the use of multiple metrics for data-driven component analyses.

PMID: 31715254 [PubMed - as supplied by publisher]