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Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.

Author(s): Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Int J Mol Sci. 2020 Jul 02;21(13): Authors: Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Article GUID: 32630624
Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast.

Author(s): Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard ...

Oncotarget. 2020 Jun 09;11(23):2182-2203 Authors: Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard É...

Article GUID: 32577164
Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.

Author(s): Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, So...

Oncotarget. 2019 Oct 08;10(56):5780-5816 Authors: Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakh...

Article GUID: 31645900
Aging and Age-related Disorders: From Molecular Mechanisms to Therapies.

Author(s): Titorenko VI

Int J Mol Sci. 2019 Jul 03;20(13): Authors: Titorenko VI

Article GUID: 31277345
Metabolomic and lipidomic analyses of chronologically aging yeast.

Author(s): Richard VR, Bourque SD, Titorenko VI

Methods Mol Biol. 2014;1205:359-73 Authors: Richard VR, Bourque SD, Titorenko VI

Article GUID: 25213255
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.

Author(s): Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Cell Cycle. 2015;14(11):1643-56 Authors: Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Article GUID: 25839782
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

Author(s): Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT

Cell Signal. 2017 12;40:172-182 Authors: Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT

Article GUID: 28923415
Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae.

Author(s): Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI

Front Biosci (Landmark Ed). 2018 Jan 01;23:1166-1194 Authors: Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI

Article GUID: 28930594
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.

Author(s): Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, ...

Oncotarget. 2017 Sep 19;8(41):69328-69350 Authors: Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofi...

Article GUID: 29050207
Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2018 Mar 15;19(3): Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29543708
Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Oxid Med Cell Longev. 2018;2018:3074769 Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29636840
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.

Author(s): Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI

Oncotarget. 2018 Mar 23;9(22):16163-16184 Authors: Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI

Article GUID: 29662634
Yeast chronological aging is linked to cell cycle regulation.

Author(s): Mohammad K, Titorenko VI

Cell Cycle. 2018;17(9):1035-1036 Authors: Mohammad K, Titorenko VI PMID: 29895227 [PubMed - in process]

Article GUID: 29895227
Molecular and Cellular Mechanisms of Aging and Age-related Disorders.

Author(s): Titorenko VI

Int J Mol Sci. 2018 Jul 14;19(7): Authors: Titorenko VI PMID: 30011889 [PubMed - indexed for MEDLINE]

Article GUID: 30011889
Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.

Author(s): Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI

Oncotarget. 2018 Oct 09;9(79):34945-34971 Authors: Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI

Article GUID: 30405886
Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.

Author(s): Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI

Oncotarget. 2019 Jan 08;10(3):313-338 Authors: Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI

Article GUID: 30719227
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Author(s): Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2019 May 01;20(9): Authors: Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Article GUID: 31052375
Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla.

Author(s): Dakik P, Medkour Y, Mohammad K, Titorenko VI

Front Physiol. 2019;10:461 Authors: Dakik P, Medkour Y, Mohammad K, Titorenko VI

Article GUID: 31057428
Title:Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.
Authors:Mohammad K,  Dakik P,  Medkour Y,  Mitrofanova D,  Titorenko VI
Link:https://www.ncbi.nlm.nih.gov/pubmed/31052375?dopt=Abstract
Category:Int J Mol Sci
PMID:31052375
Dept Affiliation: BIOLOGY
1 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. karamat.mohammad@concordia.ca.
2 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. pameladakik@gmail.com.
3 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. writetoyounes@gmail.com.
4 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. mitrofanova_darya@hotmail.com.
5 Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. vladimir.titorenko@concordia.ca.

Description:

Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Int J Mol Sci. 2019 May 01;20(9):

Authors: Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Abstract

Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do not divide, but can re-enter the cell cycle and resume proliferation if exposed to some signals from the environment. Quiescent cells in mammals and humans include adult stem cells. These cells exhibit improved stress resistance and enhanced survival ability. In response to certain extrinsic signals, adult stem cells can self-renew by dividing asymmetrically. Such asymmetric divisions not only allow the maintenance of a population of quiescent cells, but also yield daughter progenitor cells. A multistep process of the controlled proliferation of these progenitor cells leads to the formation of one or more types of fully differentiated cells. An age-related decline in the ability of adult stem cells to balance quiescence maintenance and regulated proliferation has been implicated in many aging-associated diseases. In this review, we describe many traits shared by different types of quiescent adult stem cells. We discuss how these traits contribute to the quiescence, self-renewal, and proliferation of adult stem cells. We examine the cell-intrinsic mechanisms that allow establishing and sustaining the characteristic traits of adult stem cells, thereby regulating quiescence entry, maintenance, and exit.

PMID: 31052375 [PubMed - in process]