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Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.

Author(s): Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Int J Mol Sci. 2020 Jul 02;21(13): Authors: Mohammad K, Baratang Junio JA, Tafakori T, Orfanos E, Titorenko VI

Article GUID: 32630624
Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast.

Author(s): Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard ...

Oncotarget. 2020 Jun 09;11(23):2182-2203 Authors: Dakik P, Rodriguez MEL, Junio JAB, Mitrofanova D, Medkour Y, Tafakori T, Taifour T, Lutchman V, Samson E, Arlia-Ciommo A, Rukundo B, Simard É...

Article GUID: 32577164
Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast.

Author(s): Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, So...

Oncotarget. 2019 Oct 08;10(56):5780-5816 Authors: Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakh...

Article GUID: 31645900
Aging and Age-related Disorders: From Molecular Mechanisms to Therapies.

Author(s): Titorenko VI

Int J Mol Sci. 2019 Jul 03;20(13): Authors: Titorenko VI

Article GUID: 31277345
Metabolomic and lipidomic analyses of chronologically aging yeast.

Author(s): Richard VR, Bourque SD, Titorenko VI

Methods Mol Biol. 2014;1205:359-73 Authors: Richard VR, Bourque SD, Titorenko VI

Article GUID: 25213255
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.

Author(s): Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Cell Cycle. 2015;14(11):1643-56 Authors: Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI

Article GUID: 25839782
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

Author(s): Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT

Cell Signal. 2017 12;40:172-182 Authors: Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT

Article GUID: 28923415
Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae.

Author(s): Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI

Front Biosci (Landmark Ed). 2018 Jan 01;23:1166-1194 Authors: Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI

Article GUID: 28930594
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.

Author(s): Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, ...

Oncotarget. 2017 Sep 19;8(41):69328-69350 Authors: Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofi...

Article GUID: 29050207
Some Metabolites Act as Second Messengers in Yeast Chronological Aging.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2018 Mar 15;19(3): Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29543708
Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

Author(s): Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Oxid Med Cell Longev. 2018;2018:3074769 Authors: Mohammad K, Dakik P, Medkour Y, McAuley M, Mitrofanova D, Titorenko VI

Article GUID: 29636840
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.

Author(s): Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI

Oncotarget. 2018 Mar 23;9(22):16163-16184 Authors: Arlia-Ciommo A, Leonov A, Beach A, Richard VR, Bourque SD, Burstein MT, Kyryakov P, Gomez-Perez A, Koupaki O, Feldman R, Titorenko VI

Article GUID: 29662634
Yeast chronological aging is linked to cell cycle regulation.

Author(s): Mohammad K, Titorenko VI

Cell Cycle. 2018;17(9):1035-1036 Authors: Mohammad K, Titorenko VI PMID: 29895227 [PubMed - in process]

Article GUID: 29895227
Molecular and Cellular Mechanisms of Aging and Age-related Disorders.

Author(s): Titorenko VI

Int J Mol Sci. 2018 Jul 14;19(7): Authors: Titorenko VI PMID: 30011889 [PubMed - indexed for MEDLINE]

Article GUID: 30011889
Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.

Author(s): Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI

Oncotarget. 2018 Oct 09;9(79):34945-34971 Authors: Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI

Article GUID: 30405886
Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.

Author(s): Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI

Oncotarget. 2019 Jan 08;10(3):313-338 Authors: Dakik P, McAuley M, Chancharoen M, Mitrofanova D, Lozano Rodriguez ME, Baratang Junio JA, Lutchman V, Cortes B, Simard É, Titorenko VI

Article GUID: 30719227
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

Author(s): Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Int J Mol Sci. 2019 May 01;20(9): Authors: Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI

Article GUID: 31052375
Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla.

Author(s): Dakik P, Medkour Y, Mohammad K, Titorenko VI

Front Physiol. 2019;10:461 Authors: Dakik P, Medkour Y, Mohammad K, Titorenko VI

Article GUID: 31057428
Title:Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.
Authors:Arlia-Ciommo A,  Leonov A,  Mohammad K,  Beach A,  Richard VR,  Bourque SD,  Burstein MT,  Goldberg AA,  Kyryakov P,  Gomez-Perez A,  Koupaki O,  Titorenko VI
Link:https://www.ncbi.nlm.nih.gov/pubmed/30405886?dopt=Abstract
DOI:10.18632/oncotarget.26188
Category:Oncotarget
PMID:30405886
Dept Affiliation: BIOLOGY
1 Department of Biology, Concordia University, Montreal, Quebec, Canada.

Description:

Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.

Oncotarget. 2018 Oct 09;9(79):34945-34971

Authors: Arlia-Ciommo A, Leonov A, Mohammad K, Beach A, Richard VR, Bourque SD, Burstein MT, Goldberg AA, Kyryakov P, Gomez-Perez A, Koupaki O, Titorenko VI

Abstract

All presently known geroprotective chemical compounds of plant and microbial origin are caloric restriction mimetics because they can mimic the beneficial lifespan- and healthspan-extending effects of caloric restriction diets without the need to limit calorie supply. We have discovered a geroprotective chemical compound of mammalian origin, a bile acid called lithocholic acid, which can delay chronological aging of the budding yeast Saccharomyces cerevisiae under caloric restriction conditions. Here, we investigated mechanisms through which lithocholic acid can delay chronological aging of yeast limited in calorie supply. We provide evidence that lithocholic acid causes a stepwise development and maintenance of an aging-delaying cellular pattern throughout the entire chronological lifespan of yeast cultured under caloric restriction conditions. We show that lithocholic acid stimulates the aging-delaying cellular pattern and preserves such pattern because it specifically modulates the spatiotemporal dynamics of a complex cellular network. We demonstrate that this cellular network integrates certain pathways of lipid and carbohydrate metabolism, some intercompartmental communications, mitochondrial morphology and functionality, and liponecrotic and apoptotic modes of aging-associated cell death. Our findings indicate that lithocholic acid prolongs longevity of chronologically aging yeast because it decreases the risk of aging-associated cell death, thus increasing the chance of elderly cells to survive.

PMID: 30405886 [PubMed]