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Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.

Author(s): Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C

Cereb Cortex. 2018 Oct 06;: Authors: Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C

Article GUID: 30295713
Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.

Author(s): Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Cereb Cortex. 2018 Dec 01;28(12):4210-4221 Authors: Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Article GUID: 29045570
Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2018 Oct 29;: Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Article GUID: 30371757
Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2019 Apr 01;29(4):1703 Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD PMID: 30590441 [PubMed - in process]

Article GUID: 30590441
Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging.

Author(s): DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E

Cereb Cortex. 2016 10 17;26(11):4170-4179 Authors: DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E

Article GUID: 27578494
Age Differences in the Neural Mechanisms of Intertemporal Choice Under Subjective Decision Conflict

Author(s): Eppinger B; Heekeren HR; Li SC;

Older decision-makers may capitalize on their greater experiences in financial decisions and by this offset decline in cognitive abilities. However, this pattern of results should reverse in situations that place high demands on cognitive control functions....

Article GUID: 29028956
Title:Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.
Authors:Lay BPP,  Nicolosi M,  Usypchuk AA,  Esber GR,  Iordanova MD
Link:https://www.ncbi.nlm.nih.gov/pubmed/30371757?dopt=Abstract
Category:Cereb Cortex
PMID:30371757
Dept Affiliation: CSBN
1 Department of Psychology, Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada.
2 Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY, USA.

Description:

Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

Cereb Cortex. 2018 Oct 29;:

Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Abstract

Behavioral change is paramount to adaptive behavior. Two ways to achieve alterations in previously established behavior are extinction and overexpectation. The infralimbic (IL) portion of the medial prefrontal cortex controls the inhibition of previously established aversive behavioral responses in extinction. The role of the IL cortex in behavioral modification in appetitive Pavlovian associations remains poorly understood. Here, we seek to determine if the IL cortex modulates overexpectation and extinction of reward learning. Using overexpectation or extinction to achieve a reduction in behavior, the present findings uncover a dissociable role for the IL cortex in these paradigms. Pharmacologically inactivating the IL cortex left overexpectation intact. In contrast, pre-training manipulations in the IL cortex prior to extinction facilitated the reduction in conditioned responding but led to a disrupted extinction retrieval on test drug-free. Additional studies confirmed that this effect is restricted to the IL and not dependent on the dorsally-located prelimbic cortex. Together, these results show that the IL cortex underlies extinction but not overexpectation-driven reduction in behavior, which may be due to regulating the expression of conditioned responses influenced by stimulus-response associations rather than stimulus-stimulus associations.

PMID: 30371757 [PubMed - as supplied by publisher]