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Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.

Author(s): Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C

Cereb Cortex. 2018 Oct 06;: Authors: Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C

Article GUID: 30295713
Optogenetic Activation of the Infralimbic Cortex Suppresses the Return of Appetitive Pavlovian-Conditioned Responding Following Extinction.

Author(s): Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Cereb Cortex. 2018 Dec 01;28(12):4210-4221 Authors: Villaruel FR, Lacroix F, Sanio C, Sparks DW, Chapman CA, Chaudhri N

Article GUID: 29045570
Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2018 Oct 29;: Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Article GUID: 30371757
Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2019 Apr 01;29(4):1703 Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD PMID: 30590441 [PubMed - in process]

Article GUID: 30590441
Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging.

Author(s): DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E

Cereb Cortex. 2016 10 17;26(11):4170-4179 Authors: DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E

Article GUID: 27578494
Age Differences in the Neural Mechanisms of Intertemporal Choice Under Subjective Decision Conflict

Author(s): Eppinger B; Heekeren HR; Li SC;

Older decision-makers may capitalize on their greater experiences in financial decisions and by this offset decline in cognitive abilities. However, this pattern of results should reverse in situations that place high demands on cognitive control functions....

Article GUID: 29028956
Title:Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.
Authors:Reynolds LM,  Yetnikoff L,  Pokinko M,  Wodzinski M,  Epelbaum JG,  Lambert LC,  Cossette MP,  Arvanitogiannis A,  Flores C
Link:https://www.ncbi.nlm.nih.gov/pubmed/30295713?dopt=Abstract
Category:Cereb Cortex
PMID:30295713
Dept Affiliation: PSYCHOLOGY
1 Integrated Program in Neuroscience, McGill University, Montréal, QC, Canada.
2 Department of Psychiatry and Department of Neurology and Neurosurgery, McGill University, Douglas Mental Health University Institute, Montréal, QC, Canada.
3 Department of Psychology, College of Staten Island, City University of New York, Staten Island, NY, USA.
4 CUNY Neuroscience Collaborative, The Graduate Center, City University of New York, New York, NY, USA.
5 Department of Psychology, Center for Studies in Behavioural Neurobiology, Concordia University, Montréal, QC, Canada.

Description:

Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.

Cereb Cortex. 2018 Oct 06;:

Authors: Reynolds LM, Yetnikoff L, Pokinko M, Wodzinski M, Epelbaum JG, Lambert LC, Cossette MP, Arvanitogiannis A, Flores C

Abstract

Psychiatric conditions marked by impairments in cognitive control often emerge during adolescence, when the prefrontal cortex (PFC) and its inputs undergo structural and functional maturation and are vulnerable to disruption by external events. It is not known, however, whether there exists a specific temporal window within the broad range of adolescence when the development of PFC circuitry and its related behaviors are sensitive to disruption. Here we show, in male mice, that repeated exposure to amphetamine during early adolescence leads to impaired behavioral inhibition, aberrant PFC dopamine connectivity, and reduced PFC dopamine function in adulthood. Remarkably, these deficits are not observed following exposure to the exact same amphetamine regimen at later times. These findings demonstrate that there is a critical period for the disruption of the adolescent maturation of cognitive control and PFC dopamine function and suggest that early adolescence is particularly relevant to the emergence of psychopathology in humans.

PMID: 30295713 [PubMed - as supplied by publisher]