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AHNAK C-Terminal Peptide Membrane Binding-Interactions between the Residues 5654-5673 of AHNAK and Phospholipid Monolayers and Bilayers.

Author(s): Yan X, Noël F, Marcotte I, DeWolf CE, Warschawski DE, Boisselier E

The dysferlin membrane repair complex contains a small complex, S100A10-annexin A2, which initiates membrane repair by recruiting the protein AHNAK to the membrane, where it interacts via binding sites in the C-terminal region. However, no molecular data ar...

Article GUID: 31825630
Interfacial Self-Assembly of Antimicrobial Peptide GL13K into Non-Fibril Crystalline β-Sheets.

Author(s): Youssef H, DeWolf CE

Langmuir. 2020 Jan 06;: Authors: Youssef H, DeWolf CE

Article GUID: 31880463
Energy Budget of Liquid Drop Impact at Maximum Spreading: Numerical Simulations and Experiments.

Author(s): Lee JB, Derome D, Dolatabadi A, Carmeliet J

Langmuir. 2016 Feb 09;32(5):1279-88 Authors: Lee JB, Derome D, Dolatabadi A, Carmeliet J

Article GUID: 26745364
Model Lung Surfactant Films: Why Composition Matters.

Author(s): Selladurai SL, Miclette Lamarche R, Schmidt R, DeWolf CE

Langmuir. 2016 Oct 18;32(41):10767-10775 Authors: Selladurai SL, Miclette Lamarche R, Schmidt R, DeWolf CE

Article GUID: 27641759
Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.

Author(s): Hong SH, Patel T, Ip S, Garg S, Oh JK

Langmuir. 2018 03 13;34(10):3316-3325 Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK

Article GUID: 29485889
Title:Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.
Authors:Hong SH,  Patel T,  Ip S,  Garg S,  Oh JK
Link:https://www.ncbi.nlm.nih.gov/pubmed/29485889?dopt=Abstract
Category:Langmuir
PMID:29485889
Dept Affiliation: CHEMBIOCHEM
1 Department of Chemistry and Biochemistry , Concordia University , Montreal , QC , Canada H4B 1R6.
2 Precision NanoSystems, Vancouver , BC , Canada V6T 1Z3.

Description:

Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.

Langmuir. 2018 03 13;34(10):3316-3325

Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK

Abstract

Controlling the size and narrow size distribution of polymer-based nanocarriers for targeted drug delivery is an important parameter that significantly influences their colloidal stability, biodistribution, and targeting ability. Herein, we report a high-throughput microfluidic process to fabricate colloidally stable aqueous nanoparticulate colloids with tunable sizes at 50-150 nm and narrow size distribution. The nanoparticulates are designed with different molecular weight polyesters having both ester bonds (responsive to esterase) and sulfide linkages (to oxidative reaction) on the backbones, thus exhibiting dual esterase/oxidation responses, causing the destabilization of the nanoparticulates to lead to the controlled release of encapsulated therapeutics. The systematic investigation on both microfluidic and formulation parameters enables to control their properties as allowing for decreasing nanoparticulate sizes as well as improving colloidal stability and cytotoxicity. Further to such control over smaller size and narrow size distribution, dual stimuli-responsive degradation and excellent cellular uptake could suggest that the microfluidic nanoparticulates stabilized with polymeric stabilizers could offer the versatility toward dual smart drug delivery exhibiting enhanced release kinetics.

PMID: 29485889 [PubMed - indexed for MEDLINE]