Keyword search (3,448 papers available)


Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes.

Author(s): Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Piere...

Horizontal gene transfer (HGT) is an important source of novelty in eukaryotic genomes. This is particularly true for the ochrophytes, a diverse and important group of algae. Previous studies have ...

Article GUID: 33419955
Increased drought severity tracks warming in the United States' largest river basin.

Author(s): Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, L...

Proc Natl Acad Sci U S A. 2020 May 11;: Authors: Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, Littell ...

Article GUID: 32393620
Late-spring frost risk between 1959 and 2017 decreased in North America but increased in Europe and Asia.

Author(s): Zohner CM, Mo L, Renner SS, Svenning JC, Vitasse Y, Benito BM, Ordonez A, Baumgarten F, Bastin JF, Sebald V, Reich PB, Liang J, Nabuurs GJ, ...

Late-spring frosts (LSFs) affect the performance of plants and animals across the world's temperate and boreal zones, but despite their ecological and economic impact on agriculture and forestr...

Article GUID: 32393624
Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities.

Author(s): Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG

Proc Natl Acad Sci U S A. 2019 Dec 17;: Authors: Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG PMID: 31848251 [PubMed - as supplied by publisher]

Article GUID: 31848251
Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits.

Author(s): Quintana GR, Mac Cionnaith CE, Pfaus JG

Proc Natl Acad Sci U S A. 2019 Dec 03;: Authors: Quintana GR, Mac Cionnaith CE, Pfaus JG PMID: 31796602 [PubMed - as supplied by publisher]

Article GUID: 31796602
Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans.

Author(s): Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ

Proc Natl Acad Sci U S A. 2017 12 26;114(52):13780-13785 Authors: Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ

Article GUID: 29255038
Biogenic membranes of the chloroplast in Chlamydomonas reinhardtii.

Author(s): Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19286-91 Authors: Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W

Article GUID: 23129655
Neural network retuning and neural predictors of learning success associated with cello training

Author(s): Wollman I; Penhune V; Segado M; Carpentier T; Zatorre RJ;

The auditory and motor neural systems are closely intertwined, enabling people to carry out tasks such as playing a musical instrument whose mapping between action and sound is extremely sophisticated. While the dorsal auditory stream has been shown to medi...

Article GUID: 29891670
Linking plasma formation in grapes to microwave resonances of aqueous dimers.

Author(s): Khattak HK, Bianucci P, Slepkov AD

Proc Natl Acad Sci U S A. 2019 Feb 19;: Authors: Khattak HK, Bianucci P, Slepkov AD

Article GUID: 30782800
mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Author(s): Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R;...

Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the ...

Article GUID: 29555746
Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.

Author(s): Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D

Proc Natl Acad Sci U S A. 2018 09 25;115(39):9797-9802 Authors: Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D

Article GUID: 30201715
Title:Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.
Authors:Martins D,  McKay G,  Sampathkumar G,  Khakimova M,  English AM,  Nguyen D
Link:https://www.ncbi.nlm.nih.gov/pubmed/30201715?dopt=Abstract
Category:Proc Natl Acad Sci U S A
PMID:30201715
Dept Affiliation: CHEMBIOCHEM
1 Department of Microbiology and Immunology, McGill University, Montreal, QC H3A OG4, Canada.
2 Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
3 Department of Chemistry and Biochemistry, Concordia University, Montreal, QC H3G 1M8, Canada.
4 Department of Microbiology and Immunology, McGill University, Montreal, QC H3A OG4, Canada; dao.nguyen@mcgill.ca.
5 Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Description:

Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.

Proc Natl Acad Sci U S A. 2018 09 25;115(39):9797-9802

Authors: Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D

Abstract

Metabolically quiescent bacteria represent a large proportion of those in natural and host environments, and they are often refractory to antibiotic treatment. Such drug tolerance is also observed in the laboratory during stationary phase, when bacteria face stress and starvation-induced growth arrest. Tolerance requires (p)ppGpp signaling, which mediates the stress and starvation stringent response (SR), but the downstream effectors that confer tolerance are unclear. We previously demonstrated that the SR is linked to increased antioxidant defenses in Pseudomonas aeruginosa We now demonstrate that superoxide dismutase (SOD) activity is a key factor in SR-mediated multidrug tolerance in stationary-phase P. aeruginosa Inactivation of the SR leads to loss of SOD activity and decreased multidrug tolerance during stationary phase. Genetic or chemical complementation of SOD activity of the ?relA spoT mutant (?SR) is sufficient to restore antibiotic tolerance to WT levels. Remarkably, we observe high membrane permeability and increased drug internalization upon ablation of SOD activity. Combined, our results highlight an unprecedented mode of SR-mediated multidrug tolerance in stationary-phase P. aeruginosa and suggest that inhibition of SOD activity may potentiate current antibiotics.

PMID: 30201715 [PubMed - indexed for MEDLINE]