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Author(s): Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Piere...
Horizontal gene transfer (HGT) is an important source of novelty in eukaryotic genomes. This is particularly true for the ochrophytes, a diverse and important group of algae. Previous studies have ...
Article GUID: 33419955
Author(s): Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, L...
Proc Natl Acad Sci U S A. 2020 May 11;: Authors: Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, Littell ...
Article GUID: 32393620
Author(s): Zohner CM, Mo L, Renner SS, Svenning JC, Vitasse Y, Benito BM, Ordonez A, Baumgarten F, Bastin JF, Sebald V, Reich PB, Liang J, Nabuurs GJ, ...
Late-spring frosts (LSFs) affect the performance of plants and animals across the world's temperate and boreal zones, but despite their ecological and economic impact on agriculture and forestr...
Article GUID: 32393624
Author(s): Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG
Proc Natl Acad Sci U S A. 2019 Dec 17;: Authors: Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG PMID: 31848251 [PubMed - as supplied by publisher]
Article GUID: 31848251
Author(s): Quintana GR, Mac Cionnaith CE, Pfaus JG
Proc Natl Acad Sci U S A. 2019 Dec 03;: Authors: Quintana GR, Mac Cionnaith CE, Pfaus JG PMID: 31796602 [PubMed - as supplied by publisher]
Article GUID: 31796602
Author(s): Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ
Proc Natl Acad Sci U S A. 2017 12 26;114(52):13780-13785 Authors: Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ
Article GUID: 29255038
Author(s): Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W
Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19286-91 Authors: Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W
Article GUID: 23129655
Author(s): Wollman I; Penhune V; Segado M; Carpentier T; Zatorre RJ;
The auditory and motor neural systems are closely intertwined, enabling people to carry out tasks such as playing a musical instrument whose mapping between action and sound is extremely sophisticated. While the dorsal auditory stream has been shown to medi...
Article GUID: 29891670
Author(s): Khattak HK, Bianucci P, Slepkov AD
Proc Natl Acad Sci U S A. 2019 Feb 19;: Authors: Khattak HK, Bianucci P, Slepkov AD
Article GUID: 30782800
Author(s): Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R;...
Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the ...
Article GUID: 29555746
Author(s): Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D
Proc Natl Acad Sci U S A. 2018 09 25;115(39):9797-9802 Authors: Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D
Article GUID: 30201715
| Title: | mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction |
| Authors: | Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S, Sonenberg N, Cao R, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/29555746/ |
| DOI: | 10.1073/pnas.1721578115 |
| Category: | Proc Natl Acad Sci U S A |
| PMID: | 29555746 |
| Dept Affiliation: | CSBN
1 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812. 2 Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310. 3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. 4 Department of Mathematics and Statistics, Amherst College, Amherst, MA 01002. 5 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 6 Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 7 Goodman Cancer Research Center, McGill University, Montreal, QC H3A 1A3, Canada. 8 Howard Hughes Medical Institute, McGill University, Montreal, QC H3A 1A3, Canada. 9 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812; shimon.amir@concordia.ca nahum.sonenberg@mcgill.ca rcao@umn.edu. 10 Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455. |
Description: |
Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the adult brain. Here we created a conditional mTOR knockout mouse model to address this question. Using the Cre-LoxP system, the mTOR gene was specifically knocked out in cells expressing Vip (vasoactive intestinal peptide), which represent a major population of interneurons widely distributed in the neocortex, suprachiasmatic nucleus (SCN), olfactory bulb (OB), and other brain regions. Using a combination of biochemical, behavioral, and imaging approaches, we found that mice lacking mTOR in VIP neurons displayed erratic circadian behavior and weakened synchronization among cells in the SCN, the master circadian pacemaker in mammals. Furthermore, we have discovered a critical role for mTOR signaling in mediating olfaction. Odor stimulated mTOR activation in the OB, anterior olfactory nucleus, as well as piriform cortex. Odor-evoked c-Fos responses along the olfactory pathway were abolished in mice lacking mTOR in VIP neurons, which is consistent with reduced olfactory sensitivity in these animals. Together, these results demonstrate that mTOR is a key regulator of SCN circadian clock synchrony and olfaction. |
