Keyword search (3,448 papers available)


Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes.

Author(s): Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Piere...

Horizontal gene transfer (HGT) is an important source of novelty in eukaryotic genomes. This is particularly true for the ochrophytes, a diverse and important group of algae. Previous studies have ...

Article GUID: 33419955
Increased drought severity tracks warming in the United States' largest river basin.

Author(s): Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, L...

Proc Natl Acad Sci U S A. 2020 May 11;: Authors: Martin JT, Pederson GT, Woodhouse CA, Cook ER, McCabe GJ, Anchukaitis KJ, Wise EK, Erger PJ, Dolan L, McGuire M, Gangopadhyay S, Chase KJ, Littell ...

Article GUID: 32393620
Late-spring frost risk between 1959 and 2017 decreased in North America but increased in Europe and Asia.

Author(s): Zohner CM, Mo L, Renner SS, Svenning JC, Vitasse Y, Benito BM, Ordonez A, Baumgarten F, Bastin JF, Sebald V, Reich PB, Liang J, Nabuurs GJ, ...

Late-spring frosts (LSFs) affect the performance of plants and animals across the world's temperate and boreal zones, but despite their ecological and economic impact on agriculture and forestr...

Article GUID: 32393624
Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities.

Author(s): Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG

Proc Natl Acad Sci U S A. 2019 Dec 17;: Authors: Ziter CD, Pedersen EJ, Kucharik CJ, Turner MG PMID: 31848251 [PubMed - as supplied by publisher]

Article GUID: 31848251
Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits.

Author(s): Quintana GR, Mac Cionnaith CE, Pfaus JG

Proc Natl Acad Sci U S A. 2019 Dec 03;: Authors: Quintana GR, Mac Cionnaith CE, Pfaus JG PMID: 31796602 [PubMed - as supplied by publisher]

Article GUID: 31796602
Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans.

Author(s): Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ

Proc Natl Acad Sci U S A. 2017 12 26;114(52):13780-13785 Authors: Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ

Article GUID: 29255038
Biogenic membranes of the chloroplast in Chlamydomonas reinhardtii.

Author(s): Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19286-91 Authors: Schottkowski M, Peters M, Zhan Y, Rifai O, Zhang Y, Zerges W

Article GUID: 23129655
Neural network retuning and neural predictors of learning success associated with cello training

Author(s): Wollman I; Penhune V; Segado M; Carpentier T; Zatorre RJ;

The auditory and motor neural systems are closely intertwined, enabling people to carry out tasks such as playing a musical instrument whose mapping between action and sound is extremely sophisticated. While the dorsal auditory stream has been shown to medi...

Article GUID: 29891670
Linking plasma formation in grapes to microwave resonances of aqueous dimers.

Author(s): Khattak HK, Bianucci P, Slepkov AD

Proc Natl Acad Sci U S A. 2019 Feb 19;: Authors: Khattak HK, Bianucci P, Slepkov AD

Article GUID: 30782800
mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Author(s): Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R;...

Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the ...

Article GUID: 29555746
Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa.

Author(s): Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D

Proc Natl Acad Sci U S A. 2018 09 25;115(39):9797-9802 Authors: Martins D, McKay G, Sampathkumar G, Khakimova M, English AM, Nguyen D

Article GUID: 30201715
Title:Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans.
Authors:Scaduto CM,  Kabrawala S,  Thomson GJ,  Scheving W,  Ly A,  Anderson MZ,  Whiteway M,  Bennett RJ
Link:https://www.ncbi.nlm.nih.gov/pubmed/29255038?dopt=Abstract
DOI:10.1073/pnas.1711141115
Category:Proc Natl Acad Sci U S A
PMID:29255038
Dept Affiliation: BIOLOGY
1 Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
2 Department of Biology, Concordia University, Montreal, QC, Canada H4B 1R6.
3 Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912; Richard_Bennett@brown.edu.

Description:

Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans.

Proc Natl Acad Sci U S A. 2017 12 26;114(52):13780-13785

Authors: Scaduto CM, Kabrawala S, Thomson GJ, Scheving W, Ly A, Anderson MZ, Whiteway M, Bennett RJ

Abstract

Several pathogenic Candida species are capable of heritable and reversible switching between two epigenetic states, "white" and "opaque." In Candida albicans, white cells are essentially sterile, whereas opaque cells are mating-proficient. Here, we interrogate the mechanism by which the white-opaque switch regulates sexual fecundity and identify four genes in the pheromone MAPK pathway that are expressed at significantly higher levels in opaque cells than in white cells. These genes encode the ß subunit of the G-protein complex (STE4), the pheromone MAPK scaffold (CST5), and the two terminal MAP kinases (CEK1/CEK2). To define the contribution of each factor to mating, C. albicans white cells were reverse-engineered to express elevated, opaque-like levels of these factors, either singly or in combination. We show that white cells co-overexpressing STE4, CST5, and CEK2 undergo mating four orders of magnitude more efficiently than control white cells and at a frequency approaching that of opaque cells. Moreover, engineered white cells recapitulate the transcriptional and morphological responses of opaque cells to pheromone. These results therefore reveal multiple bottlenecks in pheromone MAPK signaling in white cells and that alleviation of these bottlenecks enables efficient mating by these "sterile" cell types. Taken together, our findings establish that differential expression of several MAPK factors underlies the epigenetic control of mating in C. albicans We also discuss how fitness advantages could have driven the evolution of a toggle switch to regulate sexual reproduction in pathogenic Candida species.

PMID: 29255038 [PubMed - indexed for MEDLINE]