Keyword search (3,448 papers available)


Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.

Author(s): González Cautela BV; Quintana GR; Akerman J; Pfaus JG;

RATIONALE: Sexual side effects of chronic treatment with selective serotonin reuptake inhibitors (SSRIs) in humans include anorgasmia and loss of sexual desire and/or arousal which interferes with treatment compliance. There are few options at present to re...

Article GUID: 33242109
Correction to: Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2020 Jan 09;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31919562
A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction.

Author(s): D'Cunha TM, Chisholm A, Hryhorczuk C, Fulton S, Shalev U

RATIONAL: Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES: We investigated the...

Article GUID: 31811350
Differential disruption of conditioned ejaculatory preference in the male rat based on different sensory modalities by micro-infusions of naloxone to the medial preoptic area or ventral tegmental area.

Author(s): Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Psychopharmacology (Berl). 2019 Jul 29;: Authors: Quintana GR, Birrel M, Marceau S, Kalantari N, Bowden J, Bachoura Y, Borduas E, Lemay V, Payne JW, Cionnaith CM, Pfaus JG

Article GUID: 31359118
Acute intranasal oxytocin improves positive self-perceptions of personality.

Author(s): Cardoso C, Ellenbogen MA, Linnen AM

Psychopharmacology (Berl). 2012 Apr;220(4):741-9 Authors: Cardoso C, Ellenbogen MA, Linnen AM

Article GUID: 22012170
Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in Long-Evans rats.

Author(s): Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Psychopharmacology (Berl). 2014 Feb;231(4):753-64 Authors: Sparks LM, Sciascia JM, Ayorech Z, Chaudhri N

Article GUID: 24096535
Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.

Author(s): Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Psychopharmacology (Berl). 2015 Oct;232(20):3773-82 Authors: Sedki F, Gardner Gregory J, Luminare A, D'Cunha TM, Shalev U

Article GUID: 26246318
Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.

Author(s): Maddux JN, Chaudhri N

Psychopharmacology (Berl). 2017 Feb;234(4):727-738 Authors: Maddux JN, Chaudhri N

Article GUID: 28011981
Title:Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.
Authors:González Cautela BV,  Quintana GR,  Akerman J,  Pfaus JG, 
Link:https://www.ncbi.nlm.nih.gov/pubmed/33242109
DOI:10.1007/s00213-020-05728-0
Category:Psychopharmacology (Berl)
PMID:33242109
Dept Affiliation: PSYCHOLOGY
1 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, Canada.
2 Escuela de Psicología y Filosofía, Universidad de Tarapacá, 1010069, Arica, Arica y Parinacota, Chile.
3 Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, Canada. jpfaus@uv.mx.
4 Centro de Investigaciones Cerebrales, Universidad Veracruzana, CP 91193, Xalapa, VER, Mexico. jpfaus@uv.mx.

Description:

Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.

Psychopharmacology (Berl). 2020 Nov 26; :

Authors: González Cautela BV, Quintana GR, Akerman J, Pfaus JG

Abstract

RATIONALE: Sexual side effects of chronic treatment with selective serotonin reuptake inhibitors (SSRIs) in humans include anorgasmia and loss of sexual desire and/or arousal which interferes with treatment compliance. There are few options at present to reduce these effects. Because orgasm and desire are mediated in part by activation of sympathetic arousal, we asked whether the sympathomimetic effects of acute caffeine treatment could reverse these effects.

OBJECTIVE: The present study examined whether acute treatment with caffeine (CAF; 10 or 20 mg/kg, ip) versus vehicle could ameliorate the disruption of appetitive and consummatory measures of copulatory behavior produced by chronic fluoxetine (10 mg/kg, sc) in adult, sexually active female or male rats.

METHODS: Sexually experienced female or male rats received daily injections of FLU over a 24-day period and were tested for sexual behaviors five times at 4-day intervals during this period in bilevel pacing chambers. Females had been ovariectomized and given hormone replacement with estradiol benzoate and progesterone prior to each test. Males were left gonadally intact. Four days after the final FLU test, rats were randomly assigned to one of the three doses of CAF and received ip injections of CAF or the saline vehicle 60 min before testing.

RESULTS: Chronic FLU reduced solicitations and lordosis over time in females and reduced the number of ejaculations in males. Both doses of CAF restored solicitations and lordosis in females and ejaculations in males. On their own, both doses of CAF increased females' pacing behavior and the number of mounts and intromissions in the males.

CONCLUSIONS: Stimulation of sympathetic outflow by CAF may constitute a readily accessible on-demand treatment for the sexual side-effects of SSRIs.

PMID: 33242109 [PubMed - as supplied by publisher]