| Keyword search (3,875 papers available) | |
Author(s): Jäger AP; Steele CJ; Dreyer FR; Osterloh MR; Sadlon A; Nikulin V; Mohr B; Pulvermüller F;
Background: Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-depe...
Article GUID: 40927858
Author(s): Saputra ST; Van Hulst A; Henderson M; Brugiapaglia S; Faustini C; Kakinami L;
Background: A dual-energy x-ray absorptiometry (DXA)-derived phenotype classification based on fat mass and muscle mass has been developed for adults. We extended this to a paediatric population. Methods: Children's (= 17 years) DXA data in NHANES (n =...
Article GUID: 40878792
Author(s): Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; St...
Patients with coronary artery disease (CAD) face an increased risk of cognitive impairment, dementia, and stroke. While white matter (WM) lesions are frequently reported in patients with CAD, the e...
Article GUID: 40829939
Author(s): Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;
Introduction: Adipose tissue inflammation, driven in part by immune cells, may contribute to the elevated type 2 diabetes risk in adults with childhood-onset obesity (CO) compared to those with adult-onset obesity (AO). Weight loss can modify adipose tissue...
Article GUID: 40831565
Author(s): Pollock D; Hasanoff S; McBride G; Kanukula R; Tricco AC; Khalil H; Campbell F; Jia RM; Alexander L; Peters M; Vieira AM; Aromataris E; Nunn ...
Introduction: Scoping reviews, mapping reviews and evidence and gap maps (collectively known as 'big picture reviews') in health continue to gain popularity within the evidence ecosystem. T...
Article GUID: 40759523
Author(s): Hosseininasabnajar F; Kakinami L;
Loss of brain tissues and cognitive abilities are natural processes of aging, but longitudinal studies are limited. We explored the longitudinal association between global and regional brain measures with cognitive abilities among individuals with normal co...
Article GUID: 40739300
Author(s): Carter F; Anwander A; Johnson M; Goucha T; Adamson H; Friederici AD; Lutti A; Gauthier CJ; Weiskopf N; Bazin PL; Steele CJ;...
The study of brain structure and change in neuroscience is commonly conducted using macroscopic morphological measures of the brain such as regional volume or cortical thickness, providing little i...
Article GUID: 40705745
Author(s): Di Giovanni DA; Kersten-Oertel M; Drouin S; Collins DL;
Purpose: Image-guided neurosurgery demands precise depth perception to minimize cognitive burden during intricate navigational tasks. Existing evaluation methods rely heavily on subjective user feedback, which can be biased and inconsistent. This study uses...
Article GUID: 40650801
Author(s): Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;...
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effe...
Article GUID: 40646404
| Title: | The longitudinal effects of global and regional brain measurements on cognitive abilities |
| Authors: | Hosseininasabnajar F, Kakinami L, |
| Link: | https://pubmed.ncbi.nlm.nih.gov/40739300/ |
| DOI: | 10.1038/s41598-025-08152-6 |
| Category: | |
| PMID: | 40739300 |
| Dept Affiliation: | SOH
1 Department of Mathematics and Statistics, Concordia University, 1455 de Maisonneuve West, Montreal, QC, H3G 1M8, Canada. 2 Department of Mathematics and Statistics, Concordia University, 1455 de Maisonneuve West, Montreal, QC, H3G 1M8, Canada. lisa.kakinami@concordia.ca. 3 School of Health, Concordia University, 7200 Sherbrooke Street West, Montreal, QC, H4B 1R6, Canada. lisa.kakinami@concordia.ca. |
Description: |
Loss of brain tissues and cognitive abilities are natural processes of aging, but longitudinal studies are limited. We explored the longitudinal association between global and regional brain measures with cognitive abilities among individuals with normal cognitive status, mild cognitive impairment, and Alzheimer's Disease, including those with stable or progressive cognitive status, from the Alzheimer's Disease Neuroimaging Initiative. Follow-up was conducted approximately every six months for two to three years to classify participants by their cognitive status (n = 814). Mixed effects models were used to measure the longitudinal association between global and regional brain measures with cognitive abilities assessed by the Alzheimer's Disease Assessment cognition sub-scale after controlling for covariates. While whole brain volume (controlling for head size) affected the rate of cognition changes among those with mild cognitive impairment or Alzheimer's, other volumetric and thickness measures (hippocampus volume, ventricles volume, and entorhinal cortex thickness) had differential effects on cognition, but not on the speed of their changes. Results highlight the potential importance of different brain regions on cognition, but perhaps not on the rate of change and should be further investigated. |
