Keyword search (3,619 papers available)


The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Author(s): Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Neuron. 2019 Aug 26;: Authors: Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Article GUID: 31522764
Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats.

Author(s): Gavrila AM, Hood S, Robinson B, Amir S

PLoS One. 2017;12(6):e0179370 Authors: Gavrila AM, Hood S, Robinson B, Amir S

Article GUID: 28594962
Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders.

Author(s): Pantazopoulos H, Gamble K, Stork O, Amir S

Neural Plast. 2018;2018:5892657 Authors: Pantazopoulos H, Gamble K, Stork O, Amir S PMID: 29887881 [PubMed - indexed for MEDLINE]

Article GUID: 29887881
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.

Author(s): Frederick A, Goldsmith J, de Zavalia N, Amir S

PLoS One. 2017;12(4):e0176279 Authors: Frederick A, Goldsmith J, de Zavalia N, Amir S

Article GUID: 28423013
Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day.

Author(s): Harbour VL, Weigl Y, Robinson B, Amir S

PLoS One. 2013;8(10):e76391 Authors: Harbour VL, Weigl Y, Robinson B, Amir S

Article GUID: 24124556
Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat.

Author(s): Harbour VL, Weigl Y, Robinson B, Amir S

PLoS One. 2014;9(7):e103309 Authors: Harbour VL, Weigl Y, Robinson B, Amir S

Article GUID: 25068868
Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.

Author(s): Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Front Syst Neurosci. 2014;8:145 Authors: Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Article GUID: 25309348
Stress-induced changes in the expression of the clock protein PERIOD1 in the rat limbic forebrain and hypothalamus: role of stress type, time of day, and predictability.

Author(s): Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S

PLoS One. 2014;9(10):e111166 Authors: Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S

Article GUID: 25338089
Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Author(s): Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Nat Neurosci. 2015 Jun;18(6):855-62 Authors: Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Article GUID: 25915475
Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain.

Author(s): Al-Safadi S, Branchaud M, Rutherford S, Amir S

PLoS One. 2015;10(6):e0130085 Authors: Al-Safadi S, Branchaud M, Rutherford S, Amir S

Article GUID: 26075608
Circadian Rhythms and Psychopathology: From Models of Depression to Rhythms in Clock Gene Expression and Back Again.

Author(s): Verwey M, Al-Safadi S, Amir S

Biol Psychiatry. 2015 Aug 15;78(4):220-1 Authors: Verwey M, Al-Safadi S, Amir S PMID: 26195175 [PubMed - indexed for MEDLINE]

Article GUID: 26195175
From genes to chronotypes: the influence of circadian clock genes on our daily patterns of sleep and wakefulness.

Author(s): Verwey M, Amir S

Ann Transl Med. 2016 May;4(9):184 Authors: Verwey M, Amir S PMID: 27275497 [PubMed]

Article GUID: 27275497
Exploring the role of locomotor sensitization in the circadian food entrainment pathway.

Author(s): Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

PLoS One. 2017;12(3):e0174113 Authors: Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

Article GUID: 28301599
Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior.

Author(s): Anyan J, Verwey M, Amir S

PLoS One. 2017;12(8):e0181375 Authors: Anyan J, Verwey M, Amir S

Article GUID: 28763478
Too Depressed to Swim or Too Afraid to Stop? A Reinterpretation of the Forced Swim Test as a Measure of Anxiety-Like Behavior.

Author(s): Anyan J, Amir S

Neuropsychopharmacology. 2018 04;43(5):931-933 Authors: Anyan J, Amir S PMID: 29210364 [PubMed - in process]

Article GUID: 29210364
Title:The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.
Authors:Pathak SS,  Liu D,  Li T,  de Zavalia N,  Zhu L,  Li J,  Karthikeyan R,  Alain T,  Liu AC,  Storch KF,  Kaufman RJ,  Jin VX,  Amir S,  Sonenberg N,  Cao R
Link:https://www.ncbi.nlm.nih.gov/pubmed/31522764?dopt=Abstract
DOI:10.1016/j.neuron.2019.08.007
Category:Neuron
PMID:31522764
Dept Affiliation: CSBN
1 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA.
2 Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada.
4 Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada.
5 Children's Hospital of Eastern Ontario Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
6 Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA.
7 Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92307, USA.
8 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC H4B 1R6, Canada. Electronic address: shimon.amir@concordia.ca.
9 Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, QC H3A 1A3, Canada. Electronic address: nahum.sonenberg@mcgill.ca.
10 Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA; Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: rcao@umn.edu.

Description:

The eIF2a Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Neuron. 2019 Aug 26;:

Authors: Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Abstract

The integrated stress response (ISR) is activated in response to diverse stress stimuli to maintain homeostasis in neurons. Central to this process is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2a). Here, we report a critical role for ISR in regulating the mammalian circadian clock. The eIF2a kinase GCN2 rhythmically phosphorylates eIF2a in the suprachiasmatic circadian clock. Increased eIF2a phosphorylation shortens the circadian period in both fibroblasts and mice, whereas reduced eIF2a phosphorylation lengthens the circadian period and impairs circadian rhythmicity in animals. Mechanistically, phosphorylation of eIF2a promotes mRNA translation of Atf4. ATF4 binding motifs are identified in multiple clock genes, including Per2, Per3, Cry1, Cry2, and Clock. ATF4 binds to the TTGCAGCA motif in the Per2 promoter and activates its transcription. Together, these results demonstrate a significant role for ISR in circadian physiology and provide a potential link between dysregulated ISR and circadian dysfunction in brain diseases.

PMID: 31522764 [PubMed - as supplied by publisher]