Keyword search (3,619 papers available)


The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Author(s): Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Neuron. 2019 Aug 26;: Authors: Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R

Article GUID: 31522764
Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats.

Author(s): Gavrila AM, Hood S, Robinson B, Amir S

PLoS One. 2017;12(6):e0179370 Authors: Gavrila AM, Hood S, Robinson B, Amir S

Article GUID: 28594962
Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders.

Author(s): Pantazopoulos H, Gamble K, Stork O, Amir S

Neural Plast. 2018;2018:5892657 Authors: Pantazopoulos H, Gamble K, Stork O, Amir S PMID: 29887881 [PubMed - indexed for MEDLINE]

Article GUID: 29887881
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.

Author(s): Frederick A, Goldsmith J, de Zavalia N, Amir S

PLoS One. 2017;12(4):e0176279 Authors: Frederick A, Goldsmith J, de Zavalia N, Amir S

Article GUID: 28423013
Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day.

Author(s): Harbour VL, Weigl Y, Robinson B, Amir S

PLoS One. 2013;8(10):e76391 Authors: Harbour VL, Weigl Y, Robinson B, Amir S

Article GUID: 24124556
Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat.

Author(s): Harbour VL, Weigl Y, Robinson B, Amir S

PLoS One. 2014;9(7):e103309 Authors: Harbour VL, Weigl Y, Robinson B, Amir S

Article GUID: 25068868
Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat.

Author(s): Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Front Syst Neurosci. 2014;8:145 Authors: Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R

Article GUID: 25309348
Stress-induced changes in the expression of the clock protein PERIOD1 in the rat limbic forebrain and hypothalamus: role of stress type, time of day, and predictability.

Author(s): Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S

PLoS One. 2014;9(10):e111166 Authors: Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S

Article GUID: 25338089
Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Author(s): Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Nat Neurosci. 2015 Jun;18(6):855-62 Authors: Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Article GUID: 25915475
Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain.

Author(s): Al-Safadi S, Branchaud M, Rutherford S, Amir S

PLoS One. 2015;10(6):e0130085 Authors: Al-Safadi S, Branchaud M, Rutherford S, Amir S

Article GUID: 26075608
Circadian Rhythms and Psychopathology: From Models of Depression to Rhythms in Clock Gene Expression and Back Again.

Author(s): Verwey M, Al-Safadi S, Amir S

Biol Psychiatry. 2015 Aug 15;78(4):220-1 Authors: Verwey M, Al-Safadi S, Amir S PMID: 26195175 [PubMed - indexed for MEDLINE]

Article GUID: 26195175
From genes to chronotypes: the influence of circadian clock genes on our daily patterns of sleep and wakefulness.

Author(s): Verwey M, Amir S

Ann Transl Med. 2016 May;4(9):184 Authors: Verwey M, Amir S PMID: 27275497 [PubMed]

Article GUID: 27275497
Exploring the role of locomotor sensitization in the circadian food entrainment pathway.

Author(s): Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

PLoS One. 2017;12(3):e0174113 Authors: Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S

Article GUID: 28301599
Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior.

Author(s): Anyan J, Verwey M, Amir S

PLoS One. 2017;12(8):e0181375 Authors: Anyan J, Verwey M, Amir S

Article GUID: 28763478
Too Depressed to Swim or Too Afraid to Stop? A Reinterpretation of the Forced Swim Test as a Measure of Anxiety-Like Behavior.

Author(s): Anyan J, Amir S

Neuropsychopharmacology. 2018 04;43(5):931-933 Authors: Anyan J, Amir S PMID: 29210364 [PubMed - in process]

Article GUID: 29210364
Title:Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior.
Authors:Anyan J,  Verwey M,  Amir S
Link:https://www.ncbi.nlm.nih.gov/pubmed/28763478?dopt=Abstract
Category:PLoS One
PMID:28763478
Dept Affiliation: PSYCHOLOGY
1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada.

Description:

Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior.

PLoS One. 2017;12(8):e0181375

Authors: Anyan J, Verwey M, Amir S

Abstract

Disrupted circadian rhythms are a core feature of mood and anxiety disorders. Circadian rhythms are coordinated by a light-entrainable master clock located in the suprachiasmatic nucleus. Animal models of mood and anxiety disorders often exhibit blunted rhythms in locomotor activity and clock gene expression. Interestingly, the changes in circadian rhythms correlate with mood-related behaviours. Although animal models of depression and anxiety exhibit aberrant circadian rhythms in physiology and behavior, it is possible that the methodology being used to induce the behavioral phenotype (e.g., brain lesions, chronic stress, global gene deletion) affect behavior independently of circadian system. This study investigates the relationship between individual differences in circadian locomotor parameters and mood-related behaviors in healthy rats. The circadian phenotype of male Lewis rats was characterized by analyzing wheel running behavior under standard 12h:12h LD conditions, constant dark, constant light, and rate of re-entrainment to a phase advance. Rats were then tested on a battery of behavioral tests: activity box, restricted feeding, elevated plus maze, forced swim test, and fear conditioning. Under 12h:12h LD conditions, percent of daily activity in the light phase and variability in activity onset were associated with longer latency to immobility in the forced swim test. Variability in onset also correlated positively with anxiety-like behavior in the elevated plus maze. Rate of re-entrainment correlated positively with measures of anxiety in the activity box and elevated plus maze. Lastly, we found that free running period under constant dark was associated with anxiety-like behaviors in the activity box and elevated plus maze. Our results provide a previously uncharacterized relationship between circadian locomotor parameters and mood-related behaviors in healthy rats and provide a basis for future examination into circadian clock functioning and mood.

PMID: 28763478 [PubMed - indexed for MEDLINE]