Keyword search (3,448 papers available)


A method of calculating initial DNA strand breakage following the decay of incorporated 125I.

Author(s): Charlton DE, Humm JL

Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Mar;53(3):353-65 Authors: Charlton DE, Humm JL

Article GUID: 3257951
Comments on strand breaks calculated from average doses to the DNA from incorporated isotopes.

Author(s): Charlton DE

Radiat Res. 1988 Apr;114(1):192-7 Authors: Charlton DE

Article GUID: 3353505
Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.

Author(s): Charlton DE, Nikjoo H, Humm JL

Int J Radiat Biol. 1989 Jul;56(1):1-19 Authors: Charlton DE, Nikjoo H, Humm JL

Article GUID: 2569005
Cell survival from single passages for high-LET track-segment experiments with cell monolayers.

Author(s): Charlton DE, Turner MS

Radiat Res. 1993 Nov;136(2):297 Authors: Charlton DE, Turner MS PMID: 8248489 [PubMed - indexed for MEDLINE]

Article GUID: 8248489
Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.

Author(s): Charlton DE, Allen BJ

Int J Radiat Biol. 1993 Dec;64(6):739-47 Authors: Charlton DE, Allen BJ

Article GUID: 7903342
Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.

Author(s): Charlton DE, Turner MS

Int J Radiat Biol. 1996 Feb;69(2):213-7 Authors: Charlton DE, Turner MS PMID: 8609458 [PubMed - indexed for MEDLINE]

Article GUID: 8609458
Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.

Author(s): Charlton DE, Utteridge TD, Beddoe AH

Int J Radiat Biol. 1996 May;69(5):585-92 Authors: Charlton DE, Utteridge TD, Beddoe AH

Article GUID: 8648246
The minimum Do for cell killing for alpha-particle emitters uniformly distributed in an extended medium.

Author(s): Charlton DE

Radiat Res. 1998 Jun;149(6):646-8 Authors: Charlton DE

Article GUID: 9611104
The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.

Author(s): Charlton DE

Radiat Res. 1999 Jun;151(6):750-3 Authors: Charlton DE

Article GUID: 10360796
Radiation effects in spheroids of cells exposed to alpha emitters.

Author(s): Charlton DE

Int J Radiat Biol. 2000 Nov;76(11):1555-64 Authors: Charlton DE

Article GUID: 11098858
Title:The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.
Authors:Charlton DE
Link:https://www.ncbi.nlm.nih.gov/pubmed/10360796?dopt=Abstract
Category:Radiat Res
PMID:10360796
Dept Affiliation: PHYSICS
1 Physics Department, Concordia University, Montreal, Quebec, Canada.

Description:

The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.

Radiat Res. 1999 Jun;151(6):750-3

Authors: Charlton DE

Abstract

A model of cell survival is described for the case of closely packed clusters of cells growing in monolayers. For alpha-particle decays on the cell surfaces, it is shown that cross-firing between cells produces nonuniform dose distributions within the cluster and that cells in larger clusters are exposed on average to greater doses. The model is used to simulate the survival of SK-MEL-28 human melanoma cells labeled with different radiolabeled monoclonal antibodies. The survival data suggest that this cell line is more sensitive to high-LET radiation than previously thought.

PMID: 10360796 [PubMed - indexed for MEDLINE]