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A method of calculating initial DNA strand breakage following the decay of incorporated 125I.

Author(s): Charlton DE, Humm JL

Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Mar;53(3):353-65 Authors: Charlton DE, Humm JL

Article GUID: 3257951
Comments on strand breaks calculated from average doses to the DNA from incorporated isotopes.

Author(s): Charlton DE

Radiat Res. 1988 Apr;114(1):192-7 Authors: Charlton DE

Article GUID: 3353505
Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.

Author(s): Charlton DE, Nikjoo H, Humm JL

Int J Radiat Biol. 1989 Jul;56(1):1-19 Authors: Charlton DE, Nikjoo H, Humm JL

Article GUID: 2569005
Cell survival from single passages for high-LET track-segment experiments with cell monolayers.

Author(s): Charlton DE, Turner MS

Radiat Res. 1993 Nov;136(2):297 Authors: Charlton DE, Turner MS PMID: 8248489 [PubMed - indexed for MEDLINE]

Article GUID: 8248489
Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.

Author(s): Charlton DE, Allen BJ

Int J Radiat Biol. 1993 Dec;64(6):739-47 Authors: Charlton DE, Allen BJ

Article GUID: 7903342
Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.

Author(s): Charlton DE, Turner MS

Int J Radiat Biol. 1996 Feb;69(2):213-7 Authors: Charlton DE, Turner MS PMID: 8609458 [PubMed - indexed for MEDLINE]

Article GUID: 8609458
Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.

Author(s): Charlton DE, Utteridge TD, Beddoe AH

Int J Radiat Biol. 1996 May;69(5):585-92 Authors: Charlton DE, Utteridge TD, Beddoe AH

Article GUID: 8648246
The minimum Do for cell killing for alpha-particle emitters uniformly distributed in an extended medium.

Author(s): Charlton DE

Radiat Res. 1998 Jun;149(6):646-8 Authors: Charlton DE

Article GUID: 9611104
The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.

Author(s): Charlton DE

Radiat Res. 1999 Jun;151(6):750-3 Authors: Charlton DE

Article GUID: 10360796
Radiation effects in spheroids of cells exposed to alpha emitters.

Author(s): Charlton DE

Int J Radiat Biol. 2000 Nov;76(11):1555-64 Authors: Charlton DE

Article GUID: 11098858
Title:A method of calculating initial DNA strand breakage following the decay of incorporated 125I.
Authors:Charlton DE,  Humm JL
Link:https://www.ncbi.nlm.nih.gov/pubmed/3257951?dopt=Abstract
Category:Int J Radiat Biol Relat Stud Phys Chem Med
PMID:3257951
Dept Affiliation: PHYSICS

Description:

A method of calculating initial DNA strand breakage following the decay of incorporated 125I.

Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Mar;53(3):353-65

Authors: Charlton DE, Humm JL

Abstract

Two sources of individual Auger electron spectra and an electron track code were used with a simple model of the DNA to successfully simulate the single-strand DNA breakage measured by Martin and Haseltine (1981). The conditions of the calculation were then extended to examine patterns of single-strand breaks in both strands of the DNA duplex to score double-strand breaks. The occurrences of five types of break were scored. The total number of double-strand breaks (dsb) per decay at the site of the decay was 0.90 and 0.65 for the different Auger electron spectra. It was shown that for mammalian cells an additional source of double-strand breaks from low LET radiation added approximately 0.17 dsb/decay to each, giving a final total of 1.07 and 0.85 dsb/decay for mammalian cells depending on the electron spectrum. Further is is shown that the energy deposition in the DNA from the iodine decay is very complex, with a broad range of energy depositions and products. Even for a particular energy deposited in the DNA different types of strand break are produced. These are identified and their probabilities calculated.

PMID: 3257951 [PubMed - indexed for MEDLINE]