Keyword search (3,448 papers available)


A method of calculating initial DNA strand breakage following the decay of incorporated 125I.

Author(s): Charlton DE, Humm JL

Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Mar;53(3):353-65 Authors: Charlton DE, Humm JL

Article GUID: 3257951
Comments on strand breaks calculated from average doses to the DNA from incorporated isotopes.

Author(s): Charlton DE

Radiat Res. 1988 Apr;114(1):192-7 Authors: Charlton DE

Article GUID: 3353505
Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.

Author(s): Charlton DE, Nikjoo H, Humm JL

Int J Radiat Biol. 1989 Jul;56(1):1-19 Authors: Charlton DE, Nikjoo H, Humm JL

Article GUID: 2569005
Cell survival from single passages for high-LET track-segment experiments with cell monolayers.

Author(s): Charlton DE, Turner MS

Radiat Res. 1993 Nov;136(2):297 Authors: Charlton DE, Turner MS PMID: 8248489 [PubMed - indexed for MEDLINE]

Article GUID: 8248489
Monte Carlo calculations of ion passages through brain endothelial nuclei during boron neutron capture therapy.

Author(s): Charlton DE, Allen BJ

Int J Radiat Biol. 1993 Dec;64(6):739-47 Authors: Charlton DE, Allen BJ

Article GUID: 7903342
Use of chord lengths through the nucleus to simulate the survival of mammalian cells exposed to high LET alpha-radiation.

Author(s): Charlton DE, Turner MS

Int J Radiat Biol. 1996 Feb;69(2):213-7 Authors: Charlton DE, Turner MS PMID: 8609458 [PubMed - indexed for MEDLINE]

Article GUID: 8609458
Microdosimetry of haemopoietic stem cells irradiated by alpha particles from the short-lived products of 222Rn decays in fat cells and haemopoietic tissue.

Author(s): Charlton DE, Utteridge TD, Beddoe AH

Int J Radiat Biol. 1996 May;69(5):585-92 Authors: Charlton DE, Utteridge TD, Beddoe AH

Article GUID: 8648246
The minimum Do for cell killing for alpha-particle emitters uniformly distributed in an extended medium.

Author(s): Charlton DE

Radiat Res. 1998 Jun;149(6):646-8 Authors: Charlton DE

Article GUID: 9611104
The survival of monolayers of cells growing in clusters irradiated by 211At appended to the cell surfaces.

Author(s): Charlton DE

Radiat Res. 1999 Jun;151(6):750-3 Authors: Charlton DE

Article GUID: 10360796
Radiation effects in spheroids of cells exposed to alpha emitters.

Author(s): Charlton DE

Int J Radiat Biol. 2000 Nov;76(11):1555-64 Authors: Charlton DE

Article GUID: 11098858
Title:Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.
Authors:Charlton DE,  Nikjoo H,  Humm JL
Link:https://www.ncbi.nlm.nih.gov/pubmed/2569005?dopt=Abstract
Category:Int J Radiat Biol
PMID:2569005
Dept Affiliation: PHYSICS

Description:

Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles.

Int J Radiat Biol. 1989 Jul;56(1):1-19

Authors: Charlton DE, Nikjoo H, Humm JL

Abstract

A model of the DNA and electron and ion track structure computer codes are used to model damage in the DNA by direct action. This damage is converted into single-strand breaks using the method described by Charlton and Humm (1988) in which a minimum energy deposited in a critical volume of the DNA is correlated with the production of single-strand breaks. It is then assumed that if these single-strand breaks lie on opposite strands and are separated by less than a few base pairs they produce double-strand breaks. Absolute yields of both single- and double-strand breaks expressed in breaks/Gy-dalton are calculated and compared to measured yields. Good agreement is obtained for single-strand breaks while the calculated yields for double-strand breaks are greater than those measured.

PMID: 2569005 [PubMed - indexed for MEDLINE]