Keyword search (3,447 papers available)


Description, evaluation and scale-up potential of a model for rapid access to early intervention for psychosis.

Author(s): MacDonald K, Malla A, Joober R, Shah JL, Goldberg K, Abadi S, Doyle M, Iyer SN

Early Interv Psychiatry. 2018 12;12(6):1222-1228 Authors: MacDonald K, Malla A, Joober R, Shah JL, Goldberg K, Abadi S, Doyle M, Iyer SN

Article GUID: 29582562
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students.

Author(s): Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Stress. 2012 Jul;15(4):393-402 Authors: Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Article GUID: 22044077
The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces.

Author(s): Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Psychophysiology. 2012 Jan;49(1):128-37 Authors: Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Article GUID: 22092248
Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study.

Author(s): Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R

Psychoneuroendocrinology. 2013 Mar;38(3):399-407 Authors: Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R

Article GUID: 22889586
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychoneuroendocrinology. 2013 Mar;38(3):387-98 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 22902063
Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychophysiology. 2014 Nov;51(11):1169-77 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 25082371
Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.

Author(s): Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M

Schizophr Res. 2019 Apr;206:236-243 Authors: Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M

Article GUID: 30514643
A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

Author(s): Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

J Psychiatry Neurosci. 2019 05 01;44(3):205-213 Authors: Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

Article GUID: 30693739
Title:Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.
Authors:Ellenbogen MA,  Linnen AM,  Cardoso C,  Joober R
Link:https://www.ncbi.nlm.nih.gov/pubmed/22902063?dopt=Abstract
Category:Psychoneuroendocrinology
PMID:22902063
Dept Affiliation: PSYCHOLOGY
1 Centre for Research in Human Development, Department of Psychology, Concordia University, Montréal, Canada. mark.ellenbogen@concordia.ca

Description:

Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.

Psychoneuroendocrinology. 2013 Mar;38(3):387-98

Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Abstract

The administration of oxytocin promotes prosocial behavior in humans. The mechanism by which this occurs is unknown, but it likely involves changes in social information processing. In a randomized placebo-controlled study, we examined the influence of intranasal oxytocin and placebo on the interference control component of inhibition (i.e. ability to ignore task-irrelevant information) in 102 participants using a negative affective priming task with sad, angry, and happy faces. In this task, participants are instructed to respond to a facial expression of emotion while simultaneously ignoring another emotional face. On the subsequent trial, the previously-ignored emotional valence may become the emotional valence of the target face. Inhibition is operationalized as the differential delay between responding to a previously-ignored emotional valence and responding to an emotional valence unrelated to the previous one. Although no main effect of drug administration on inhibition was observed, a drug × depressive symptom interaction (ß = -0.25; t = -2.6, p < 0.05) predicted the inhibition of sad faces. Relative to placebo, participants with high depression scores who were administered oxytocin were unable to inhibit the processing of sad faces. There was no relationship between drug administration and inhibition among those with low depression scores. These findings are consistent with increasing evidence that oxytocin alters social information processing in ways that have both positive and negative social outcomes. Because elevated depression scores are associated with an increased risk for major depressive disorder, difficulties inhibiting mood-congruent stimuli following oxytocin administration may be associated with risk for depression.

PMID: 22902063 [PubMed - indexed for MEDLINE]