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Description, evaluation and scale-up potential of a model for rapid access to early intervention for psychosis.

Author(s): MacDonald K, Malla A, Joober R, Shah JL, Goldberg K, Abadi S, Doyle M, Iyer SN

Early Interv Psychiatry. 2018 12;12(6):1222-1228 Authors: MacDonald K, Malla A, Joober R, Shah JL, Goldberg K, Abadi S, Doyle M, Iyer SN

Article GUID: 29582562
Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students.

Author(s): Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Stress. 2012 Jul;15(4):393-402 Authors: Linnen AM, Ellenbogen MA, Cardoso C, Joober R

Article GUID: 22044077
The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces.

Author(s): Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Psychophysiology. 2012 Jan;49(1):128-37 Authors: Ellenbogen MA, Linnen AM, Grumet R, Cardoso C, Joober R

Article GUID: 22092248
Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study.

Author(s): Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R

Psychoneuroendocrinology. 2013 Mar;38(3):399-407 Authors: Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R

Article GUID: 22889586
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychoneuroendocrinology. 2013 Mar;38(3):387-98 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 22902063
Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation.

Author(s): Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Psychophysiology. 2014 Nov;51(11):1169-77 Authors: Ellenbogen MA, Linnen AM, Cardoso C, Joober R

Article GUID: 25082371
Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.

Author(s): Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M

Schizophr Res. 2019 Apr;206:236-243 Authors: Sauvé G, Kline RB, Shah JL, Joober R, Malla A, Brodeur MB, Lepage M

Article GUID: 30514643
A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

Author(s): Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

J Psychiatry Neurosci. 2019 05 01;44(3):205-213 Authors: Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E

Article GUID: 30693739
Title:Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study.
Authors:Cardoso C,  Ellenbogen MA,  Orlando MA,  Bacon SL,  Joober R
Link:https://www.ncbi.nlm.nih.gov/pubmed/22889586?dopt=Abstract
Category:Psychoneuroendocrinology
PMID:22889586
Dept Affiliation: PSYCHOLOGY
1 Centre for Research in Human Development, Department of Psychology, Concordia University, Montréal, QC, Canada.

Description:

Intranasal oxytocin attenuates the cortisol response to physical stress: a dose-response study.

Psychoneuroendocrinology. 2013 Mar;38(3):399-407

Authors: Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R

Abstract

INTRODUCTION: Intranasal oxytocin attenuates cortisol levels during social stress inductions. However, no research to date has documented the dose-response relation between intranasal oxytocin administration and cortisol, and researchers examining intranasal oxytocin have not examined the cortisol response to physical stress. We therefore examined the effects of 24IU and 48IU of intranasal oxytocin on the cortisol response to vigorous exercise.

METHOD: Seventeen males participated in a randomized, placebo-controlled, double-blind, and within-subject experiment. Participants engaged in vigorous exercise for 60min following the administration of placebo or intranasal oxytocin on three occasions. Saliva samples and mood ratings were collected at eight intervals across each session.

RESULTS: Salivary cortisol concentrations changed over time, peaking after 60min of exercise (quadratic: F(1,16)=7.349, p=.015, partial ?(2)=.32). The 24IU dose of oxytocin attenuated cortisol levels relative to placebo (F(1,16)=4.496, p=.05, partial ?(2)=.22) and the 48IU dose, although the latter fell just short of statistical significance (F(1,16)=3.054, p=.10, partial ?(2)=.16). There was no difference in the cortisol response to exercise in participants who were administered 48IU of intranasal oxytocin relative to placebo. Intranasal oxytocin had no effect on mood.

CONCLUSION: This is the first study to demonstrate that the effect of intranasal oxytocin on salivary cortisol is dose-dependent, and that intranasal oxytocin attenuates cortisol levels in response to physical stress. Future research using exogenous oxytocin will need to consider the possibility of dose-response relations.

PMID: 22889586 [PubMed - indexed for MEDLINE]