Keyword search (3,619 papers available)


Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography.

Author(s): Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B...

OBJECTIVE: Fast Oscillations (FO) >40 Hz are a promising biomarker of the epileptogenic zone (EZ). Evidence using scalp electroencephalography (EEG) remains scarce. We assessed if electrical source...

Article GUID: 33450578
Contactless Capacitive Electrocardiography Using Hybrid Flexible Printed Electrodes.

Author(s): Lessard-Tremblay M, Weeks J, Morelli L, Cowan G, Gagnon G, Zednik RJ

Traditional capacitive electrocardiogram (cECG) electrodes suffer from limited patient comfort, difficulty of disinfection and low signal-to-noise ratio in addition to the challenge of integrating them in wearables. A novel hybrid flexible cECG electrode wa...

Article GUID: 32927651
The antibacterial activity of p-tert-butylcalix[6]arene and its effect on a membrane model: molecular dynamics and Langmuir film studies.

Author(s): Wrobel EC, de Lara LS, do Carmo TAS, Castellen P, Lazzarotto M, de Lázaro SR, Camilo A, Caseli L, Schmidt R, DeWolf CE, Wohnrath K

Phys Chem Chem Phys. 2020 Mar 03;: Authors: Wrobel EC, de Lara LS, do Carmo TAS, Castellen P, Lazzarotto M, de Lázaro SR, Camilo A, Caseli L, Schmidt R, DeWolf CE, Wohnrath K

Article GUID: 32124897
Computer-Aided Diagnosis System of Alzheimer's Disease Based on Multimodal Fusion: Tissue Quantification Based on the Hybrid Fuzzy-Genetic-Possibilistic Model and Discriminative Classification Based on the SVDD Model.

Author(s): Lazli L, Boukadoum M, Ait Mohamed O

Brain Sci. 2019 Oct 22;9(10): Authors: Lazli L, Boukadoum M, Ait Mohamed O

Article GUID: 31652635
The first MICCAI challenge on PET tumor segmentation.

Author(s): Hatt M, Laurent B, Ouahabi A, Fayad H, Tan S, Li L, Lu W, Jaouen V, Tauber C, Czakon J, Drapejkowski F, Dyrka W, Camarasu-Pop S, Cervenansky...

Med Image Anal. 2018 02;44:177-195 Authors: Hatt M, Laurent B, Ouahabi A, Fayad H, Tan S, Li L, Lu W, Jaouen V, Tauber C, Czakon J, Drapejkowski F, Dyrka W, Camarasu-Pop S, Cervenansky F, Girard P...

Article GUID: 29268169
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.

Author(s): Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, ...

Oncotarget. 2017 Sep 19;8(41):69328-69350 Authors: Leonov A, Feldman R, Piano A, Arlia-Ciommo A, Lutchman V, Ahmadi M, Elsaser S, Fakim H, Heshmati-Moghaddam M, Hussain A, Orfali S, Rajen H, Roofi...

Article GUID: 29050207
Expedition Cognition: A Review and Prospective of Subterranean Neuroscience With Spaceflight Applications.

Author(s): Mogilever NB, Zuccarelli L, Burles F, Iaria G, Strapazzon G, Bessone L, Coffey EBJ

Front Hum Neurosci. 2018;12:407 Authors: Mogilever NB, Zuccarelli L, Burles F, Iaria G, Strapazzon G, Bessone L, Coffey EBJ

Article GUID: 30425628
Human Physiology During Exposure to the Cave Environment: A Systematic Review With Implications for Aerospace Medicine.

Author(s): Zuccarelli L, Galasso L, Turner R, Coffey EJB, Bessone L, Strapazzon G

Front Physiol. 2019;10:442 Authors: Zuccarelli L, Galasso L, Turner R, Coffey EJB, Bessone L, Strapazzon G

Article GUID: 31068833
Title:The antibacterial activity of p-tert-butylcalix[6]arene and its effect on a membrane model: molecular dynamics and Langmuir film studies.
Authors:Wrobel EC,  de Lara LS,  do Carmo TAS,  Castellen P,  Lazzarotto M,  de Lázaro SR,  Camilo A,  Caseli L,  Schmidt R,  DeWolf CE,  Wohnrath K
Link:https://www.ncbi.nlm.nih.gov/pubmed/32124897?dopt=Abstract
DOI:10.1039/d0cp00432d
Category:Phys Chem Chem Phys
PMID:32124897
Dept Affiliation: CNSR
1 Department of Chemistry, Universidade Estadual de Ponta Grossa, Ponta Grossa, Par84030-900, Brazil. karen.woh@gmail.com.
2 Department of Physics, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná 84030-900, Brazil.
3 Academic Department of Mathematic, Universidade Federal Tecnológica do Paraná - Campus Ponta Grossa, Ponta Grossa, Paraná 84016-210, Brazil.
4 Department of Organic Chemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil.
5 Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema, São Paulo (SP) 09972-970, Brazil.
6 Department of Chemistry and Biochemistry and Concordia Centre for NanoScience Research, Concordia University, 7141 Sherbrooke Street West, Montreal, Québec H4B 1R6, Canada.

Description:

The antibacterial activity of p-tert-butylcalix[6]arene and its effect on a membrane model: molecular dynamics and Langmuir film studies.

Phys Chem Chem Phys. 2020 Mar 03;:

Authors: Wrobel EC, de Lara LS, do Carmo TAS, Castellen P, Lazzarotto M, de Lázaro SR, Camilo A, Caseli L, Schmidt R, DeWolf CE, Wohnrath K

Abstract

The antibacterial activity of a calixarene derivative, p-tert-butylcalix[6]arene (Calix6), was assessed and was shown not to inhibit the growth of E. coli, S. aureus and B. subtilis bacteria. With the aim of gaining more insights into the absence of antibacterial activity of Calix6, the interaction of this derivative with DPPG, a bacterial cell membrane lipid, was studied. Langmuir monolayers were used as the model membrane. Pure DPPG and pure Calix6 monolayers, as well as binary DPPG:Calix6 mixtures were studied using surface pressure measurements, compressional modulus, Brewster angle and fluorescence microscopies, ellipsometry, polarization-modulation infrared reflection absorption spectroscopy and molecular dynamics simulations. Thermodynamic properties of the mixed monolayers were additionally calculated using thermodynamic parameters. The analysis of isotherms showed that Calix6 significantly affects the DPPG monolayers, modifying the isotherm profile and increasing the molecular area, in agreement with the molecular dynamics simulations. The presence of Calix6 in the mixed monolayers decreased the interfacial elasticity, indicating that calixarene disrupts the strong intermolecular interactions of DPPG hindering its organization into a compact arrangement. At low molar ratios of Calix6, the DPPG:Calix6 interactions are preferentially attractive, due to the interactions between the hydrophobic tails of DPPG and the tert-butyl groups of Calix6. Increasing the proportion of calixarene generates repulsive interactions. Calix6 significantly affects the hydrophobic tail organization, which was confirmed by PM-IRRAS measurements. Calix6 appears to be expelled from the mixed films at a biologically relevant surface pressure, p = 30 mN m-1, indicating a low interaction with the cell membrane model related to the absence of antibacterial activity.

PMID: 32124897 [PubMed - as supplied by publisher]