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Effects of Independent Component Analysis on Magnetoencephalography Source Localization in Pre-surgical Frontal Lobe Epilepsy Patients

Author(s): Pellegrino G, Xu M, Alkuwaiti A, Porras-Bettancourt M, Abbas G, Lina JM, Grova C, Kobayashi E,...

Objective: Magnetoencephalography source imaging (MSI) of interictal epileptiform discharges (IED) is a useful presurgical tool in the evaluation of drug-resistant frontal lobe epilepsy (FLE) patie...

Article GUID: 32582009
Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.

Author(s): Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Hum Brain Mapp. 2020 May 09;: Authors: Pellegrino G, Hedrich T, Porras-Bettancourt M, Lina JM, Aydin Ü, Hall J, Grova C, Kobayashi E

Article GUID: 32386115
Magnetoencephalography resting state connectivity patterns as indicatives of surgical outcome in epilepsy patients.

Author(s): Aydin Ü, Pellegrino G, Bin Ka'b Ali O, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C

J Neural Eng. 2020 Mar 18;: Authors: Aydin Ü, Pellegrino G, Bin Ka'b Ali O, Abdallah C, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 32191632
Differences in MEG and EEG power-law scaling explained by a coupling between spatial coherence and frequency: a simulation study.

Author(s): Bénar CG, Grova C, Jirsa VK, Lina JM

J Comput Neurosci. 2019 Jul 11;: Authors: Bénar CG, Grova C, Jirsa VK, Lina JM

Article GUID: 31292816
Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy.

Author(s): Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Brain Topogr. 2016 Jan;29(1):162-81 Authors: Heers M, Chowdhury RA, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E

Article GUID: 25609211
MEG-EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy.

Author(s): Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Brain Topogr. 2015 Nov;28(6):785-812 Authors: Chowdhury RA, Zerouali Y, Hedrich T, Heers M, Kobayashi E, Lina JM, Grova C

Article GUID: 26016950
Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients.

Author(s): von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E

Brain Topogr. 2016 Mar;29(2):218-31 Authors: von Ellenrieder N, Pellegrino G, Hedrich T, Gotman J, Lina JM, Grova C, Kobayashi E

Article GUID: 26830767
Intracranial EEG potentials estimated from MEG sources: A new approach to correlate MEG and iEEG data in epilepsy.

Author(s): Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E

Hum Brain Mapp. 2016 May;37(5):1661-83 Authors: Grova C, Aiguabella M, Zelmann R, Lina JM, Hall JA, Kobayashi E

Article GUID: 26931511
SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity.

Author(s): Lee K, Lina JM, Gotman J, Grova C

Neuroimage. 2016 07 01;134:434-449 Authors: Lee K, Lina JM, Gotman J, Grova C

Article GUID: 27046111
Source localization of the seizure onset zone from ictal EEG/MEG data.

Author(s): Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2016 07;37(7):2528-46 Authors: Pellegrino G, Hedrich T, Chowdhury R, Hall JA, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 27059157
Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Author(s): Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Hum Brain Mapp. 2018 01;39(1):218-231 Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Article GUID: 29024165
Reproducibility of EEG-MEG fusion source analysis of interictal spikes: Relevance in presurgical evaluation of epilepsy.

Author(s): Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Hum Brain Mapp. 2018 02;39(2):880-901 Authors: Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C

Article GUID: 29164737
Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy.

Author(s): Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C

Neuroimage Clin. 2018;20:71-84 Authors: Lee K, Khoo HM, Lina JM, Dubeau F, Gotman J, Grova C

Article GUID: 30094158
Optimal positioning of optodes on the scalp for personalized functional near-infrared spectroscopy investigations.

Author(s): Machado A, Cai Z, Pellegrino G, Marcotte O, Vincent T, Lina JM, Kobayashi E, Grova C

J Neurosci Methods. 2018 Nov 01;309:91-108 Authors: Machado A, Cai Z, Pellegrino G, Marcotte O, Vincent T, Lina JM, Kobayashi E, Grova C

Article GUID: 30107210
Complex patterns of spatially extended generators of epileptic activity: Comparison of source localization methods cMEM and 4-ExSo-MUSIC on high resolution EEG and MEG data.

Author(s): Chowdhury RA, Merlet I, Birot G, Kobayashi E, Nica A, Biraben A, Wendling F, Lina JM, Albera L, Grova C...

Complex patterns of spatially extended generators of epileptic activity: Comparison of source localization methods cMEM and 4-ExSo-MUSIC on high resolution EEG and MEG data.

Neuroimage. 2...

Article GUID: 27561712
Comparison of the spatial resolution of source imaging techniques in high-density EEG and MEG.

Author(s): Hedrich T, Pellegrino G, Kobayashi E, Lina JM, Grova C

Neuroimage. 2017 08 15;157:531-544 Authors: Hedrich T, Pellegrino G, Kobayashi E, Lina JM, Grova C

Article GUID: 28619655
Beyond spindles: interactions between sleep spindles and boundary frequencies during cued reactivation of motor memory representations.

Author(s): Laventure S, Pinsard B, Lungu O, Carrier J, Fogel S, Benali H, Lina JM, Boutin A, Doyon J

Sleep. 2018 Sep 01;41(9): Authors: Laventure S, Pinsard B, Lungu O, Carrier J, Fogel S, Benali H, Lina JM, Boutin A, Doyon J

Article GUID: 30137521
Title:Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.
Authors:Pellegrino G,  Hedrich T,  Chowdhury RA,  Hall JA,  Dubeau F,  Lina JM,  Kobayashi E,  Grova C
Link:https://www.ncbi.nlm.nih.gov/pubmed/29024165?dopt=Abstract
Category:Hum Brain Mapp
PMID:29024165
Dept Affiliation: PERFORM
1 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montreal, Quebec, Canada.
2 Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
3 IRCCS Fondazione San Camillo Hospital, Venice, Italy.
4 Departement de Génie Electrique, Ecole de Technologie Supérieure, Montreal, Quebec, Canada.
5 Centre De Recherches En Mathématiques, Montreal, Quebec, Canada.
6 Centre D'études Avancées En Médecine Du Sommeil, Centre De Recherche De L'hôpital Sacré-Coeur De Montréal, Montreal, Quebec, Canada.
7 Physics Department and PERFORM Centre, Concordia University, Montreal, Quebec, Canada.

Description:

Clinical yield of magnetoencephalography distributed source imaging in epilepsy: A comparison with equivalent current dipole method.

Hum Brain Mapp. 2018 01;39(1):218-231

Authors: Pellegrino G, Hedrich T, Chowdhury RA, Hall JA, Dubeau F, Lina JM, Kobayashi E, Grova C

Abstract

OBJECTIVE: Source localization of interictal epileptic discharges (IEDs) is clinically useful in the presurgical workup of epilepsy patients. It is usually obtained by equivalent current dipole (ECD) which localizes a point source and is the only inverse solution approved by clinical guidelines. In contrast, magnetic source imaging using distributed methods (dMSI) provides maps of the location and the extent of the generators, but its yield has not been clinically validated. We systematically compared ECD versus dMSI performed using coherent Maximum Entropy on the Mean (cMEM), a method sensitive to the spatial extent of the generators.

METHODS: 340 source localizations of IEDs derived from 49 focal epilepsy patients with foci well-defined through intracranial EEG, MRI lesions, and surgery were analyzed. The comparison was based on the assessment of the sublobar concordance with the focus and of the distance between the source and the focus.

RESULTS: dMSI sublobar concordance was significantly higher than ECD (81% vs 69%, P?<?0.001), especially for extratemporal lobe sources (dMSI?=?84%; ECD?=?67%, P?<?0.001) and for seizure free patients (dMSI?=?83%; ECD?=?70%, P?<?0.001). The median distance from the focus was 4.88 mm for ECD and 3.44 mm for dMSI (P?<?0.001). ECD dipoles were often wrongly localized in deep brain regions.

CONCLUSIONS: dMSI using cMEM exhibited better accuracy. dMSI also offered the advantage of recovering more realistic maps of the generator, which could be exploited for neuronavigation aimed at targeting invasive EEG and surgical resection. Therefore, dMSI may be preferred to ECD in clinical practice. Hum Brain Mapp 39:218-231, 2018. © 2017 Wiley Periodicals, Inc.

PMID: 29024165 [PubMed - indexed for MEDLINE]