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Using intracellular plasmonics to characterize nanomorphology in human cells.

Author(s): Sohrabi Kashani A, Piekny A, Packirisamy M

Determining the characteristics and localization of nanoparticles inside cells is crucial for nanomedicine design for cancer therapy. Hyperspectral imaging is a fast, straightforward, reliable, and accurate method to study the interactions of nanoparticles ...

Article GUID: 33365137
Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review.

Author(s): Badilescu S, Raju D, Bathini S, Packirisamy M

Nano-islands are entities (droplets or other shapes) that are formed by spontaneous dewetting (agglomeration, in the early literature) of thin and very thin metallic (especially gold) films on a substrate, done by post-deposition heating or by using other s...

Article GUID: 33066088
Toward Task Autonomy in Robotic Cardiac Ablation: Learning-Based Kinematic Control of Soft Tendon-Driven Catheters.

Author(s): Jolaei M, Hooshiar A, Dargahi J, Packirisamy M

Soft Robot. 2020 Jul 14;: Authors: Jolaei M, Hooshiar A, Dargahi J, Packirisamy M

Article GUID: 32678722
Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases.

Author(s): Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Int J Mol Sci. 2019 Dec 05;20(24): Authors: Subramaniyan Parimalam S, Badilescu S, Sonenberg N, Bhat R, Packirisamy M

Article GUID: 31817343
Nano-Bio Interactions of Extracellular Vesicles with Gold Nanoislands for Early Cancer Diagnosis.

Author(s): Bathini S, Raju D, Badilescu S, Kumar A, Ouellette RJ, Ghosh A, Packirisamy M

Res (Wash D C). 2018;2018:3917986 Authors: Bathini S, Raju D, Badilescu S, Kumar A, Ouellette RJ, Ghosh A, Packirisamy M

Article GUID: 31549028
Flow force augmented 3D suspended polymeric microfluidic (SPMF3 ) platform.

Author(s): Marzban M, Dargahi J, Packirisamy M

Electrophoresis. 2019 Feb;40(3):388-400 Authors: Marzban M, Dargahi J, Packirisamy M

Article GUID: 30025169
Tuning of Morphology and Stability of Gold Nanostars Through pH Adjustment.

Author(s): Kumar R, Badilescu S, Packirisamy M

J Nanosci Nanotechnol. 2019 Aug 01;19(8):4617-4622 Authors: Kumar R, Badilescu S, Packirisamy M

Article GUID: 30913757
Efficient Low Shear Flow-based Trapping of Biological Entities.

Author(s): Sohrabi Kashani A, Packirisamy M

Sci Rep. 2019 Apr 02;9(1):5511 Authors: Sohrabi Kashani A, Packirisamy M

Article GUID: 30940862
Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium.

Author(s): Surendran V, Chiulli T, Manoharan S, Knisley S, Packirisamy M, Chandrasekaran A

Biosensors (Basel). 2019 May 28;9(2): Authors: Surendran V, Chiulli T, Manoharan S, Knisley S, Packirisamy M, Chandrasekaran A

Article GUID: 31141923
The effect of hydrogen nanobubbles on the morphology of gold-gelatin bionanocomposite films and their optical properties.

Author(s): Alsawafta M, Badilescu S, Truong VV, Packirisamy M

Nanotechnology. 2012 Feb 17;23(6):065305 Authors: Alsawafta M, Badilescu S, Truong VV, Packirisamy M

Article GUID: 22248640
Title:Using intracellular plasmonics to characterize nanomorphology in human cells.
Authors:Sohrabi Kashani A,  Piekny A,  Packirisamy M
Link:https://www.ncbi.nlm.nih.gov/pubmed/33365137
DOI:10.1038/s41378-020-00219-w
Category:Microsyst Nanoeng
PMID:33365137
Dept Affiliation: BIOLOGY
1 Optical Bio-Microsystem Lab, Micro-Nano-Bio-Integration Center, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, 1455 De Maisonneuve Blvd. W., Montreal, QC H3G 1M8 Canada.
2 Department of Biology, Concordia University, 7141 Sherbrooke Street W., Montreal, QC H4B 1R6 Canada.

Description:

Using intracellular plasmonics to characterize nanomorphology in human cells.

Microsyst Nanoeng. 2020; 6:110

Authors: Sohrabi Kashani A, Piekny A, Packirisamy M

Abstract

Determining the characteristics and localization of nanoparticles inside cells is crucial for nanomedicine design for cancer therapy. Hyperspectral imaging is a fast, straightforward, reliable, and accurate method to study the interactions of nanoparticles and intracellular components. With a hyperspectral image, we could collect spectral information consisting of thousands of pixels in a short time. Using hyperspectral images, in this work, we developed a label-free technique to detect nanoparticles in different regions of the cell. This technique is based on plasmonic shifts taking place during the interaction of nanoparticles with the surrounding medium. The unique optical properties of gold nanoparticles, localized surface plasmon resonance bands, are influenced by their microenvironment. The LSPR properties of nanoparticles, hence, could provide information on regions in which nanoparticles are distributed. To examine the potential of this technique for intracellular detection, we used three different types of gold nanoparticles: nanospheres, nanostars and Swarna Bhasma (SB), an Indian Ayurvedic/Sidha medicine, in A549 (human non-small cell lung cancer) and HepG2 (human hepatocellular carcinoma) cells. All three types of particles exhibited broader and longer bands once they were inside cells; however, their plasmonic shifts could change depending on the size and morphology of particles. This technique, along with dark-field images, revealed the uniform distribution of nanospheres in cells and could provide more accurate information on their intracellular microenvironment compared to the other particles. The region-dependent optical responses of nanoparticles in cells highlight the potential application of this technique for subcellular diagnosis when particles with proper size and morphology are chosen to reflect the microenvironment effects properly.

PMID: 33365137 [PubMed]