Keyword search (3,448 papers available)


mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Author(s): Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl R...

Neuropsychopharmacology. 2020 May 15;: Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, C...

Article GUID: 32413893
Extra-striatal D2/3 receptor availability in youth at risk for addiction.

Author(s): Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Ségu...

Neuropsychopharmacology. 2020 Apr 07;: Authors: Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, S&...

Article GUID: 32259831
Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression.

Author(s): Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Neuropsychopharmacology. 2018 04;43(5):1138-1145 Authors: Tozzi L, Farrell C, Booij L, Doolin K, Nemoda Z, Szyf M, Pomares FB, Chiarella J, O'Keane V, Frodl T

Article GUID: 29182159
Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala.

Author(s): Sciascia JM, Reese RM, Janak PH, Chaudhri N

Neuropsychopharmacology. 2015 Nov;40(12):2801-12 Authors: Sciascia JM, Reese RM, Janak PH, Chaudhri N

Article GUID: 25953360
Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids.

Author(s): Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, Arvanitogiannis A, Alquier T, Fulton S

Neuropsychopharmacology. 2016 Feb;41(3):811-21 Authors: Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, Arvanitogiannis A, Alquier T, Fulton S

Article GUID: 26171719
Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core.

Author(s): D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Neuropsychopharmacology. 2017 Apr;42(5):1136-1145 Authors: D'Cunha TM, Daoud E, Rizzo D, Bishop AB, Russo M, Mourra G, Hamel L, Sedki F, Shalev U

Article GUID: 27824052
Varenicline Reduces Context-Induced Relapse to Alcohol-Seeking through Actions in the Nucleus Accumbens.

Author(s): Lacroix F, Pettorelli A, Maddux JN, Heidari-Jam A, Chaudhri N

Neuropsychopharmacology. 2017 Apr;42(5):1037-1048 Authors: Lacroix F, Pettorelli A, Maddux JN, Heidari-Jam A, Chaudhri N

Article GUID: 27834390
Non-Contingent Exposure to Amphetamine in Adolescence Recruits miR-218 to Regulate Dcc Expression in the VTA.

Author(s): Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitogiannis A, Flores C

Neuropsychopharmacology. 2018 03;43(4):900-911 Authors: Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitogiannis A, Flores C

Article GUID: 29154364
Too Depressed to Swim or Too Afraid to Stop? A Reinterpretation of the Forced Swim Test as a Measure of Anxiety-Like Behavior.

Author(s): Anyan J, Amir S

Neuropsychopharmacology. 2018 04;43(5):931-933 Authors: Anyan J, Amir S PMID: 29210364 [PubMed - in process]

Article GUID: 29210364
Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding.

Author(s): Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Neuropsychopharmacology. 2019 Feb 08;: Authors: Khoo SY, LeCocq MR, Deyab GE, Chaudhri N

Article GUID: 30758331
Title:mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.
Authors:Cox SML,  Tippler M,  Jaworska N,  Smart K,  Castellanos-Ryan N,  Durand F,  Allard D,  Benkelfat C,  Parent S,  Dagher A,  Vitaro F,  Boivin M,  Pihl RO,  Côté S,  Tremblay RE,  Séguin JR,  Leyton M
Link:https://www.ncbi.nlm.nih.gov/pubmed/32413893?dopt=Abstract
DOI:10.1038/s41386-020-0708-x
Category:Neuropsychopharmacology
PMID:32413893
Dept Affiliation: CSBN
1 Department of Psychiatry, McGill University, Montreal, QC, Canada.
2 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
3 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
4 Institute of Mental Health Research, Affiliated with the University of Ottawa, Ottawa, ON, Canada.
5 Yale PET Center, Yale University, New Haven, CT, USA.
6 School of Psychoeducation, Université de Montréal, Montreal, QC, Canada.
7 CHU Ste-Justine Research Center, Montreal, QC, Canada.
8 Department of Psychology, Université Laval, Quebec, QC, Canada.
9 Department of Psychology, McGill University, Montreal, QC, Canada.
10 Department of Social and Preventative Medicine, Université de Montréal, Montreal, QC, Canada.
11 Department of Pediatrics and Psychology, Université de Montréal, Montreal, QC, Canada.
12 School of Public Health, University College Dublin, Belfield, Dublin, Ireland.
13 Department of Psychiatry and Addictology, Université de Montréal, Montreal, QC, Canada.
14 Department of Psychiatry, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
15 Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
16 Department of Psychology, McGill University, Montreal, QC, Canada. marco.leyton@mcgill.ca.
17 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, QC, Canada. marco.leyton@mcgill.ca.

Description:

mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Neuropsychopharmacology. 2020 May 15;:

Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M

Abstract

The excitatory neurotransmitter glutamate has been implicated in experience-dependent neuroplasticity and drug-seeking behaviors. Type 5 metabotropic glutamate (mGlu5) receptors might be particularly important. They are critically involved in synaptic plasticity and their availability has been reported to be lower in people with alcohol, tobacco, and cocaine use disorders. Since these reductions could reflect effects of drug use or pre-existing traits, we used positron emission tomography to measure mGlu5 receptor availability in young adults at elevated risk for addictions. Fifty-nine participants (age 18.5±0.6) were recruited from a longitudinal study that has followed them since birth. Based on externalizing traits that predict future substance use problems, half were at low risk, half were at high risk. Cannabis use histories varied markedly and participants were divided into three subgroups: zero, low, and high use. Compared to low risk volunteers, those at elevated risk had lower [11C]ABP688 binding potential (BPND) values in the striatum, amygdala, insula, and orbitofrontal cortex (OFC). Cannabis use by risk group interactions were observed in the striatum and OFC. In these regions, low [11C]ABP688 BPND values were only seen in the high risk group that used high quantities of cannabis. When these high risk, high cannabis use individuals were compared to all other participants, [11C]ABP688 BPND values were lower in the striatum, OFC, and insula. Together, the study provides evidence that mGlu5 receptor availability is low in youth at elevated risk for addictions, particularly those who frequently use cannabis.

PMID: 32413893 [PubMed - as supplied by publisher]